🧬 What can happen when #RNA scientists meet beyond their own labs? The 2025/2026 Milan RNA Salon closed with 6 events, 13 scientific talks, 190+ participants from 13+ institutes and 3 roundtables.

Transforming cryo-lift-out one section at a time pubmed.ncbi.nlm.nih.gov/42447744/ #cryoEM

Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)

Utilising in situ structural biology to uncover fundamental mechanisms of cytoskeletal regulation, we're excited to present Helen Foster with an Early Career Research Award in 2027! Helen's research on immune cell cytoskeletal remodeling could open new frontiers in molecular immunology.

📢 First preprint from the Casañal Lab! Excited to share our work on human NSUN2, done together with the brilliant @ecleroy.bsky.social. Using #CryoEM, we capture the dramatic structural rearrangement of tRNA as it flips a cytidine into the NSUN2 catalytic pocket for m⁵C modification. Take a look👇

Elodie Carmen Leroy@ecleroy.bsky.social · 5mo ago

🚨 Preprint alert! We solved the structure of human NSUN2 bound to Asp tRNA, revealing how it installs m⁵C and recognizes RNAs #CryoEM #RNABiology A collab between Casañal & Gullerova labs, with @miclass.bsky.social and me working side by side as co-first authors 🔗 doi.org/10.64898/202... (0/7🧵)

Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!

🥳Today at HT, we took the time to celebrate one another, recognising colleagues who have stood out for their contributions or positive attitude. 👏Congratulations to the winners: Roberto Zigiotto (Above & Beyond Award) and @giovannimaltinti.bsky.social (Good Vibes Award)!

Excited to share the (hard) work of @zawarshah.bsky.social in its final form: www.nature.com/articles/s41... A lot of insights into RNA Polymerase selectivity at snRNAs promoters !! As these promoters are often used for heterologous expression of RNAs (ie guide RNAs), you better know how they work

Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters - Nature Communications

The snRNA Activating Protein Complex (SNAPc) mediates snRNA transcription by RNA Pol II and III. Here, the authors have used cryo-EM to resolve the structure of the SNAPc-bound RNA Pol III pre-initiat...

nature.com

JOB ALERT!!! The National Facility for Structural Biology at @humantechnopole.bsky.social is HIRING!! BlueSky-less Andrea Graziadei is looking for a technician to join his Unit and push #structuralproteomics to new, uncharted territories!! 1/3

Our review of Intraflagellar transport is out now! We cover lots of the recent advances in our understanding of IFT, and where we think there are still some gaps. www.nature.com/articles/s41...

The intraflagellar transport cycle - Nature Reviews Molecular Cell Biology

Intraflagellar transport (IFT) ensures delivery of selected proteins into cilia. The IFT protein complexes IFT-A and IFT-B polymerize at the base of the cilium to form an anterograde train that facili...

nature.com