This is amazing - the power of vaccines!! Cervical cancer deaths fall to zero in young women given HPV vaccine www.bbc.co.uk/news/article...

Cervical cancer deaths fall to zero in young women given HPV vaccine

A new study finds that hundreds of lives have been saved since school-age girls were offered the HPV jab in 2008.

bbc.co.uk

It is finally out there in published form. 🎉 #MicroSplit (with an 𝕊) #Microscopy 🔬 #AI 🤖 www.nature.com/articles/s41... And no paywall... so... enjoy the read! 💸 👋 This is where the post could end... but I will have to go on for a bit below... 😉 🧵

💡 What does it take to build a research institute that truly serves human health and sets a new standard for how science is done? Read more here: humantechnopole.it/en/news/huma...

Human Technopole scales up Italian science for Europe’s health future - Human Technopole

“Shaping the future of human health, together”: Human Technopole’s new claim was the central theme of the event held this morning at the Senate of the Republic. The conference “Human Technopole Founda...

humantechnopole.it

Bravissima @helenfoster.bsky.social !!! Keep it up!!!!

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 4mo ago

Congrats to the @biochemsoc.bsky.social 2027 Award winners, including @helenfoster.bsky.social who has won an Early Career Research Award. Helen was a PhD student in Andrew Carter’s group in the LMB’s Structural Studies Division, and is now a Group Leader at the University of Leeds. #LMBalumni

We've spent the last year building something at @humantechnopole.bsky.social that we think is genuinely needed: #AI that works across biological scales and data modalities, not just within them. A thread on what we're doing, why, and who we're looking for. A 🧵... 1/9

Just WOW! Tremendous work

Carter Lab@carter-lab.bsky.social · 4mo ago

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

We are #hiring! #GroupLeader positions open at #IRBBarcelona in #ChemicalBiology and #StructuralBiology. Application deadline: May 22, 2026 𝗚𝗿𝗼𝘂𝗽 𝗟𝗲𝗮𝗱𝗲𝗿 𝗶𝗻 𝗖𝗵𝗲𝗺𝗶𝗰𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 ➡️ https://shorturl.at/1tE3n 𝗚𝗿𝗼𝘂𝗽 𝗟𝗲𝗮𝗱𝗲𝗿 𝗶𝗻 𝗦𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 ➡️ https://shorturl.at/eKiJn #IRBJobs #Jobs #AcademicSky

“I think it’s a real mistake to forget where the pipeline for all this begins.” John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it. www.crick.ac.uk/news/2026-03...

🚨 Preprint alert! We solved the structure of human NSUN2 bound to Asp tRNA, revealing how it installs m⁵C and recognizes RNAs #CryoEM #RNABiology A collab between Casañal & Gullerova labs, with @miclass.bsky.social and me working side by side as co-first authors 🔗 doi.org/10.64898/202... (0/7🧵)

📢 First preprint from the Casañal Lab! Excited to share our work on human NSUN2, done together with the brilliant @ecleroy.bsky.social. Using #CryoEM, we capture the dramatic structural rearrangement of tRNA as it flips a cytidine into the NSUN2 catalytic pocket for m⁵C modification. Take a look👇

Elodie Carmen Leroy@ecleroy.bsky.social · 5mo ago

🚨 Preprint alert! We solved the structure of human NSUN2 bound to Asp tRNA, revealing how it installs m⁵C and recognizes RNAs #CryoEM #RNABiology A collab between Casañal & Gullerova labs, with @miclass.bsky.social and me working side by side as co-first authors 🔗 doi.org/10.64898/202... (0/7🧵)

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

Astounding words and performance. Take 2 mins to listen to it.

Omg. WTF is Happening?@lalahaenzy.bsky.social · 6mo ago

Sir Ian McKellen performing a monologue from Shakespeare’s Sir Thomas More on the Stephen Colbert show. Never have I heard this monologue performed with such a keen sense of prescience. Nor have I ever been in this exact historical moment.TY Sir Ian, for reaching us once again. #Pinks #ProudBlue

🔬 How do proteins know when and how to move? Our @francescryoem.bsky.social Group reveals how sortilin recognises thyroglobulin on its path to #thyroid hormone release via a short, flexible molecular “tag”. Published in @natcomms.nature.com humantechnopole.it/en/news/how-... @iboniardi.bsky.social

How sortilin senses thyroglobulin along its pathway to thyroid hormone release - Human Technopole

Human Technopole researchers have identified the molecular mechanisms by which the membrane receptor sortilin binds thyroglobulin along its pathway to the release of thyroid hormones within the thyroi...

humantechnopole.it

@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.

Multiscale structure of chromatin condensates explains phase separation and material properties

The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...

science.org

🧪An international study led by Prof. Roderick Lim has discovered that nuclear pore complexes—gateways in the nuclear membrane—are not rigid or gel-like as once thought. Instead, their interiors are constantly moving and rearranging. @unibas.ch @snsf.ch 👉 www.biozentrum.unibas.ch/news/detail/...

Shapeshifting gates guard the cell nucleus

An international study led by the University of Basel has discovered that nuclear pore complexes – tiny gateways in the nuclear membrane – are not rigid or gel-like as once thought. Their interiors ar...

biozentrum.unibas.ch

This alternative view of “condensate” biogenesis is compatible with everything that LLPS claims for itself, including the apparent liquid-like behavior that people a bit ignorant of dynamics find so exciting. I explained this here www.embopress.org/doi/full/10....

On the role of phase separation in the biogenesis of membraneless compartments | The EMBO Journal

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

embopress.org

The things you find in your photo roll #2. For some reason, in August 2013 I took a picture of this charming letter from Max Perutz to Jim Watson, written shortly before Max died.

Major modes of behavior within low-pLDDT regions were identified through a survey of human proteome predictions provided by the AlphaFold Protein Structure Database #AlphaFold2 #StructurePrediction #ConditionalFolding doi.org/10.1107/S205...

Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social. www.sciencedirect.com/science/arti... Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.

This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues go.nature.com/3VNrH1s

Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

go.nature.com

Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪 @mpi-nat.bsky.social #Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation

@gabrieleniola.bsky.social @ilpost.it vi segnalo questo errore in un vostro articolo. Nel film di Del Toro Waltz non è Pretorius, né uno scienziato che fa cose dopo la presunta morte del barone. Ciao e keep it up!

Final days to get signed up for the Symposium on Structural Proteomics in Milan, 6-8 October! Registrations and abstract submissions for posters and talks still open until ❗this sunday August 31st! @humantechnopole.bsky.social Find out more at ssp2025.squarespace.com

This ‘landmark’ study describes the structural mechanism of strand exchange by the RAD51 filament using cryogenic structural, biochemical, and single-molecule analyses. buff.ly/Ieh84gj

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. www.biorxiv.org/content/10.1...

🧬 We're excited to host the 13th Symposium on Structural #Proteomics at HT in Milan on 6–8 Oct 25! Join this international meeting with talks on protein structure and interactions by crosslinking MS, HDX-MS, native MS, chemoproteomics & more 👉 ssp2025.squarespace.com ▶️ @ssp2025.bsky.social

NEW from me at STAT: We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out. More @statnews.com: www.statnews.com/2025/07/21/c... 🖥️🩺🧪🧬 #bioML

AlphaFold developer Google DeepMind to fund CASP as NIH funding falls short

Protein structure prediction contest CASP gets temporary funding from Google DeepMind as NIH grant runs out.

statnews.com

Online Now: Condensin II activation by M18BP1 Online now:

Condensin II activation by M18BP1

Borsellini, Conti, Cutts, Harris, et al. identify an interaction between M18BP1 and condensin II that is essential for condensin II activity and chromatin localization. MCPH1 keeps the interphase genome uncondensed by competing with M18BP1. A phosphorylation-driven switch allows M18BP1 to trigger condensation at mitotic onset.

dlvr.it

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv