The #ClimateChange crisis is also a #PublicHealth crisis. Warming temperatures affect health on a global scale. #MedSky

We are happy to present a new paper on gene regulation on the way to regenerating the spinal cord www.biorxiv.org/content/10.6... 🧵 1/4

Baseline regulatory programs in larval and adult neural progenitors converge towards an injury-induced state after spinal cord injury

Regeneration after spinal cord injury requires progenitor cells to convert injury-associated signals into coordinated remodeling of gene regulatory programs. Mammalian spinal progenitors show limited ...

biorxiv.org

That's our group's work! Yay! Fastest paper ever - submitted 24 Feb, published online 26 May! I want that for ALL papers going forward!

TUD | Center for Regenerative Therapies Dresden (CRTD)@crtd-tud.bsky.social · 3w ago

Maestros of Healing 🧬 Why can zebrafish heal spinal cord injuries while humans can't? Scientists from the @beckergroup.bsky.social found that first-responder neutrophils do more than clean up - they release IL-4 to quiet the chaos so nerves can regrow. 🧠✨ Read more ➡️ tud.link/dycug1 #CMCBnews

Congratulations to Dr. Markus Westphal and Dr. Rachel Branch from @beckergroup.bsky.social on this cool preprint! They show that spinal cord injury induces a stem-like progenitor state, and that these cells actively signal to their environment!! Find more on @biorxivpreprint.bsky.social

Spinal injury induces a stem cell-like progenitor state that promotes regenerative neurogenesis via clcf1 in zebrafish.

After spinal injury, zebrafish, in contrast to mammals, show regenerative neurogenesis, characterized by enhanced injury-induced proliferation of ependymo-radial glial cells (ERGs) and an increase in ...

biorxiv.org

Happy to share my first preprint as senior author! Our great PhD student @kimjuli.bsky.social in @beckergroup.bsky.social shows that macrophages are quite dynamic and heterogeneous after spinal cord injury in 🐟 and all express regeneration-relevant genes! Find more in @biorxivpreprint.bsky.social

Diverse origins and transcriptional profiles of macrophages in a spinal lesion in zebrafish

The injury responses of tissue-resident macrophages in the CNS (microglia) and blood-derived macrophages (BDMs) play key roles in successful regeneration of the zebrafish spinal cord, but the origins ...

biorxiv.org

Very glad to announce that my first postdoc study in @beckergroup.bsky.social has been officially published in @plosbiology.org If you ever wondered how microglia control the production of new neurons and simultaneously promote spinal cord repair, this is your paper. Microglia rule! 🤟🐟

The microglia-derived protein Sema4ab attenuates regenerative neurogenesis after spinal cord injury in zebrafish

Zebrafish can regenerate neurons after spinal cord injury, but the mechanisms influencing this ability remain unknown. This study shows that Sema4ab, a protein expressed in lesion-reactive microglia, attenuates regenerative neurogenesis by directly regulating neural progenitors and altering cytokine signaling in the niche.

journals.plos.org

What are the mechanisms allowing #zebrafish to #regenerate their neurons after spinal cord injury? This study by @albertodseara.bsky.social , Catherine Becker, Thomas Becker &co shows that a protein in #microglia regulates regenerative #neurogenesis in multiple ways 🧪#AcademicSky plos.io/4xy2CcB

What are the mechanisms allowing #zebrafish to #regenerate their neurons after spinal cord injury? This study by @albertodseara.bsky.social , Catherine Becker, Thomas Becker &co shows that a protein in #microglia regulates regenerative #neurogenesis in multiple ways 🧪#AcademicSky plos.io/4xy2CcB

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