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Mike Spencer Chapman

@mikespencerchapman.bsky.social

Haematology doctor & researcher, UK. Interested in blood ageing, transplant, cancer and development. Lapsed musician.

23 Posts232 Follower187 Folgt
Mike Spencer Chapman@mikespencerchapman.bsky.social · last yr.

Lovely piece from @s-j-aitken.bsky.social and Claudia Arnedo Pec discussing our recent paper in @nature.com on persistent mutagenic DNA lesions... Love the title! Puts it in the context of their beautiful previous work on lesion segregation

Sarah Aitken@s-j-aitken.bsky.social · last yr.

🧩DNA Lesions Piece Together Impossible Trees🧩 This was a fun piece to write (and illustrate!) with Dr Claudia Arnedo Pac about @mikespencerchapman.bsky.social and co’s recent @nature.com paper. Thank you for the invitation, Maria @cp-trendsgenetics.bsky.social authors.elsevier.com/sd/article/S...

A person made up of jigsaw pieces representing the millions and millions of unique cells with unique genomes, which build a picture of our lifetime of cellular experiences. Four panels, anticlockwise from top left, highlight key findings. (i) Phylogeny-violating variants (PVVs) caused by persistent DNA lesions explain otherwise ‘impossible’ trees. (ii) An estimate (in chronological time) of when lesions were acquired and for how long they persist. (iii) Demonstration in vivo that individual DNA lesions can give rise to both single nucleotide variants (SNVs) and small insertions or deletions (indels) in different cell cycles; this is a form of multiallelic variation, which more commonly relates to two alternate SNVs at the same site. (iv) Identification of lesion segregation of APOBEC mutagenesis, implicating that genome-wide mutagenesis occurred within a single cell cycle and that lesion segregation could explain the strand coordination of clustered APOBEC mutations commonly seen in cancer genomes.
Sarah Aitken@s-j-aitken.bsky.social · 2y ago

🌟NEW PREPRINT ALERT!🌟 We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution” www.biorxiv.org/content/10.1... 🧵[1/12]

Genetic background sets the trajectory of cancer evolution

Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...

biorxiv.org

Barts Cancer Institute (Queen Mary University of London)@qmbci.bsky.social · 2y ago

📰 Some forms of DNA damage linger unrepaired in healthy cells for years, according to a @nature.com study led by Dr Mike Spencer Chapman @mikespencerchapman.bsky.social at BCI and @sangerinstitute.bsky.social.  The findings could inform our understanding of #cancer development. 🧪 #medsky

Discovery of lingering DNA damage could change our understanding of cancer development - Barts Cancer Institute - Queen Mary University of London

Dr Michael Spencer Chapman and team have uncovered forms of DNA damage in healthy cells that can persist unrepaired for years.

bit.ly

Trevor Graham@trevorgraham.bsky.social · 2y ago

This is a cool paper about the surprisingly long-term persistence of DNA lesions (single stranded DNA errors) in the human body. Exquisitely meticulous work from conception through to execution. Congratulations @mikespencerchapman.bsky.social

Mike Spencer Chapman@mikespencerchapman.bsky.social · 2y ago

So pleased to have the paper out, available here: www.nature.com/articles/s41586-024-08423-8 For me this was discovery science as I had always hoped it would be. A lot of fun, and some proper detective work with plenty of twists & turns on the way. Brief thread below

Mike Spencer Chapman@mikespencerchapman.bsky.social · 2y ago

Yes! @s-j-aitken.bsky.social your fantastic work on lesion segregation really was the foundation for this.. gave us early confidence that some lesions were able to persist through multiple cell divisions & that our theory was viable

Sarah Aitken@s-j-aitken.bsky.social · 2y ago

Building on our discovery of #LesionSegregation, @mikespencerchapman.bsky.social and colleagues from @sangerinstitute.bsky.social find that some DNA lesions can persist in humans for months or years! "Prolonged persistence of mutagenic DNA lesions in somatic cells" www.nature.com/articles/s41...