Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

Nature Metabolism, Published online: 29 April 2026; doi:10.1038/s42255-026-01520-0This study develops a platform that enables simultaneous, multiplexed tracing of 30 nitrogen isotope-labelled metabolites, uncovering differences in pyrimidine synthesis pathway choice between primitive and differentiated cells.

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Brain cells refine nitrogen choice with maturity

Nature Metabolism, Published online: 29 April 2026; doi:10.1038/s42255-026-01519-7Nitrogen metabolism is more complex and less mapped than carbon pathways owing to the diversity of nitrogen sources and disjointed routing. Savani et al. develop a multiplexed nitrogen labelling platform to trace system-wide nitrogen flows, revealing how undifferentiated and mature cells select nitrogen sources for pyrimidine nucleotide synthesis.

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Cell maturity determines pyrimidine synthesis pathway preference - Children's Medical Center Research Institute (CRI) | Dallas Texas

McBrayer Lab uses their new nitrogen metabolism profiling platform, organoid model to discover modification of enzyme CAD activates de novo pathway A cell’s development stage intrinsically determines ...

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