TODAY in @dallasnews.com: Read more about McBrayer Lab's #relentlessdiscovery in @science.org, with a cameo from CRI Genetic & Metabolic Disease Program Director @rjdlab.bsky.social 🧪

The Dallas Morning News@dallasnews.com · 6d ago

A new study from Dallas scientists suggests a mutated gene leads to severe neurological impairment, and points towards a potential treatment strategy.

To learn more about our research and how to apply, check out neochenlab.org

Very honored to be featured in Cytoskeleton Spotlight! If you would like to learn a bit more about me and my research, but also discover the answers to critical questions such as which cytoskeletal protein I would swap places with for a day be sure to check it out! @cytoskeljournal.bsky.social

Join us this fall for the 2026 FASEB Aneuploidy Conference! Learn about exciting science in chromosome biology, genome stability, development, and cancer + plenty of trainee talks and career development sessions. @faseborg.bsky.social #ANESRC Abstracts due August 3! events.faseb.org/event/Aneupl...

ONLINE NOW in @science.org: Latest #relentlessdiscovery from CRI's McBrayer Lab uses their newly developed biosensor to track missing metabolite (αKG) in rare childhood brain disorder, GPT2 deficiency. 🧪 Read more ⬇️ cri.utsw.edu/new-biosenso...

New biosensor tracks down missing metabolite from childhood brain disorder - Children's Medical Center Research Institute (CRI) | Dallas Texas

Science study shows alpha-ketoglutarate supplementation may delay progression of GPT2 deficiency, rare inborn error of metabolism DALLAS – July 16, 2026 – Scientists at Children’s Medical Center Resea...

cri.utsw.edu

Here at CRI #relentlessdiscovery = #NeverChaseReality and McBrayer Lab is ready to cheer the #USMNT  to the next round. Gooooooooal ⚽️🏆#StarsAndStripes #FIFAWorldCup #FWC26 #WeAre26

One more Dr. on his way to Dr. Dr. ✔️ Congrats, Mark, on a successful defense! Dr. Mannino is headed back to medical school to finish his M.D. One more @seanjmorrison.bsky.social grad student off to continue #relentlessdiscovery

ONLINE NOW in @natcellbio.nature.com: ecDNA anchors to H3K27ac-marked active regions on chromosomes to survive normal mitotic cell division and persist into the next generation of daughter cells. Read more about the latest #relentlessdiscovery from CRI's Wu Lab ⬇️ @yipengxie.bsky.social

Mechanisms for ecDNA survival during cell division uncovered - Children's Medical Center Research Institute (CRI) | Dallas Texas

Targeting transcription machinery could disturb ecDNA maintenance, reduce oncogenicity Dallas – June 24, 2026 – Extrachromosomal DNA (ecDNA) — circular, fractured chromosomal DNA found in the nucleus ...

cri.utsw.edu

We made the cover 🤩 !! Check out this incredible painting by @kahsage.bsky.social !!

👏👏 On a roll with #MotivationMonday & another successful dissertation defense! Congrats to @haozhulab.bsky.social & @rjdlab.bsky.social lab grad student Roger Liang. Dr. Liang is headed back to medical school to finish up his M.D. Onward! #relentlessdiscovery 🧪

ONLINE now in @natcellbio.nature.com: Our newest PI @henrydebelly.bsky.social has published his postdoctoral work about Rac & Rho. Check out his 🧵⬇️ #relentlessdiscovery 🧪

Henry De Belly@henrydebelly.bsky.social · 2mo ago

Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?

#MotivationMonday another successful Ph.D. defense! Congrats to McBrayer Lab grad student Charley Edgar, (second from right). Dr. Edgar is headed back to medical school to finish up his M.D. Onward! #relentlessdiscovery 🧪

Coverage of @peterlylab.bsky.social's #relentlessdiscovery 🧪 originally published in @cellpress.bsky.social ⬇️

Nature Reviews Molecular Cell Biology@natrevmcb.nature.com · 2mo ago

New Online! DNA voyages through intercellular tunnels

🚨Seeking 2 #postdocs ⬇️ join the #relentlessdiscovery 🧪 #ScienceJobs #SciJobs #JobRxiv #STEMJobs #AcademicTwitter #PhDJobs

Peter Ly@peterlylab.bsky.social · 2mo ago

The Ly Lab is recruiting two #postdocs to study intercellular DNA transfer. Join us to tackle fundamental questions at the intersection of genome instability, cell-cell communication, and cancer evolution. Please share! 🙏 Full posting: cri.utsw.edu/careers/

Proud milestone for our lab – Congrats to our first two graduate students, Lizz Maurais, PhD, and Justin Engel, PhD (@justeng95.bsky.social)! We also celebrated Lizz’s last day as she moves on to an exciting new adventure. Good luck Lizz!

Had a fun conversation with @sciencenews.bsky.social about our recent findings. Thanks for covering our work!

Science News@sciencenews.bsky.social · 3mo ago

Like prisoners tunneling out of jail, damaged DNA travels via tubelike structures between neighboring cells. https://www.sciencenews.org/article/damaged-dna-spread-nanotubes-cells-cancer

Like prisoners tunneling out of jail, damaged DNA travels via tubelike structures between neighboring cells. https://www.sciencenews.org/article/damaged-dna-spread-nanotubes-cells-cancer

Damaged DNA can spread between human cells. What could that mean for cancer?

DNA can voyage along intercellular highways called tunneling nanotubes. It’s a phenomenon that could potentially spread tumor DNA to healthy cells.

sciencenews.org

#relentlessdiscovery from @peterlylab.bsky.social 🧪

Children's Research Institute at UT Southwestern@cri-utsw.bsky.social · 3mo ago

ONLINE NOW in @cellcellpress.bsky.social: @peterlylab.bsky.social has discovered large pieces of DNA can transfer directly between human cells & that DNA can persist, change how the recipient cell functions. 🧪 Read more about this #relentlessdiscovery ⬇️ cri.utsw.edu

🧵👇 for @peterlylab.bsky.social's deep-dive into the deets of his latest #relentlessdiscovery 🧪 worth a 🔖

Peter Ly@peterlylab.bsky.social · 3mo ago

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...

ONLINE NOW in @cellcellpress.bsky.social: @peterlylab.bsky.social has discovered large pieces of DNA can transfer directly between human cells & that DNA can persist, change how the recipient cell functions. 🧪 Read more about this #relentlessdiscovery ⬇️ cri.utsw.edu

Human cells can exchange genomic DNA that alters cell behavior - Children's Medical Center Research Institute (CRI) | Dallas Texas

Children’s Research Institute scientists discover that DNA transferred between cells can be inherited, remain biologically active DALLAS – May 19, 2026 – Scientists at Children’s Medical Center Resear...

cri.utsw.edu

#thesisThursday: Been a week since Greg Mannino from @haozhulab.bsky.social successfully defended! Congrats, Dr. Mannino 😎 and best of luck continuing the #relentlessdiscovery as a postdoc at @washu.edu.

We already thought @haozhulab.bsky.social hung the (liver-shaped) moon🌙 & now his #relentlessdiscovery is promulgated. Check out Chp 6, "When Our Bodies Autocorrect," p140 to read how somatic mutations could give us "hope." Great topic, @roxannekhamsi.bsky.social! 🧪 Watch out #booktok 🤓

Roxanne Khamsi@roxannekhamsi.bsky.social · 3mo ago

This week marks the release of my book Beyond Inheritance 🎉 📖 . It tells the stories of patients with mysterious ailments who have been saved by doctors' new understanding of genetics. And how whales can teach us about preserving our DNA as we age. Available as book & audiobook: tinyurl.com/5yjsr97n

Congrats, @walterwchen.bsky.social! 🎉 The next CRI postdoc off to pursue more #relentlessdiscovery 🧪

Walter W. Chen, MD, PhD@walterwchen.bsky.social · 4mo ago

Thrilled to share that I’ll be starting my lab as an Assistant Professor and Endowed Scholar in the UT Southwestern Molecular Biology Dept this Fall! 🥳 We’ll study #peroxisomes #mitochondria #metabolism via the lens of neonatology 👶🏻, a very exciting frontier in medicine! #neotwitter

More highlights from @natmetabolism.nature.com about the importance of newly developed nitrogen mapping 🧪 www.nature.com/articles/s42... #relentlessdiscovery @milansavani.com

Children's Research Institute at UT Southwestern@cri-utsw.bsky.social · 3mo ago

ONLINE NOW in @natmetabolism.nature.com: McBrayer Lab & first-author @milansavani.com have discovered cell maturity determines pyrimidine synthesis pathway preference using their new nitrogen metabolism profiling platform, organoid model. More ⬇️ cri.utsw.edu/cell-maturit... #relentlessdiscovery 🧪

1/12 🛣️ Mapping nitrogen metabolism has lagged carbon due to substrate diversity. In @natmetabolism.nature.com, we introduce a platform to do this mapping at scale and identify mechanisms by which differentiation state dictates pyrimidine synthesis. 🧵👇 🔗 www.nature.com/articles/s42...

ONLINE NOW in @natmetabolism.nature.com: McBrayer Lab & first-author @milansavani.com have discovered cell maturity determines pyrimidine synthesis pathway preference using their new nitrogen metabolism profiling platform, organoid model. More ⬇️ cri.utsw.edu/cell-maturit... #relentlessdiscovery 🧪

Cell maturity determines pyrimidine synthesis pathway preference - Children's Medical Center Research Institute (CRI) | Dallas Texas

McBrayer Lab uses their new nitrogen metabolism profiling platform, organoid model to discover modification of enzyme CAD activates de novo pathway A cell’s development stage intrinsically determines ...

cri.utsw.edu

I am so grateful for this honor - grateful to my mentors, lab, and family. Thank you @seanjmorrison.bsky.social for your support. And how great to be elected with some very good friends and two awesome UTSW colleagues, Elizabeth Chen and Joel Elmquist. Feeling very fortunate today.

Children's Research Institute at UT Southwestern@cri-utsw.bsky.social · 3mo ago

🌟From the desk of @seanjmorrison.bsky.social: It's a great day for CRI, which now has 2 @nasonline.org members. Congratulations to @rjdlab.bsky.social and his laboratory on this recognition for the quality and impact of their work! #relentlessdiscovery 🧪 cri.utsw.edu/deberardinis...

Big congrats to my postdoc mentor @rjdlab.bsky.social on his election to NAS!! 🎉🎉🎉 An inspiring physician-scientist and wonderful person and mentor.

Children's Research Institute at UT Southwestern@cri-utsw.bsky.social · 3mo ago

🌟From the desk of @seanjmorrison.bsky.social: It's a great day for CRI, which now has 2 @nasonline.org members. Congratulations to @rjdlab.bsky.social and his laboratory on this recognition for the quality and impact of their work! #relentlessdiscovery 🧪 cri.utsw.edu/deberardinis...

🌟From the desk of @seanjmorrison.bsky.social: It's a great day for CRI, which now has 2 @nasonline.org members. Congratulations to @rjdlab.bsky.social and his laboratory on this recognition for the quality and impact of their work! #relentlessdiscovery 🧪 cri.utsw.edu/deberardinis...

Three UT Southwestern faculty members elected to National Academy of Sciences

The National Academy of Sciences (NAS) today elected three UT Southwestern Medical Center scientists into its membership. Election to the NAS is one of the highest honors in the United States for Amer...

cri.utsw.edu

Pleased to share our review on chromosomal instability (CIN) and aneuploidy in cancer, led by Amanda Mennie. Now out @annualreviews.bsky.social! www.annualreviews.org/content/jour...

Impact of Chromosomal Instability and Aneuploidy in Cancer Development

Somatic human cells contain a diploid genome consisting of 23 pairs of chromosomes. The maintenance of this diploid state is essential across all layers of biological organization, ranging from the ph...

annualreviews.org