Congratulations @kangyongloh.bsky.social, Spencer Zhao, @carolynbertozzi.bskyverified.social, and the whole team– including my longtime and wonderful collaborator Zhenan Bao– for this key step in our journey toward genetically-targeted chemical assembly in biology. www.nature.com/articles/s41...

I love this thread by @glycoshape.org, this is @bsky.app at its best!

GlycoShape@glycoshape.org · 10mo ago

Super interesting work from @carolynbertozzi.bskyverified.social group about the effects of glycosylation in protein structure and function at the proteome scale 🤯💥🤩 Results show that sialylation and fucosylation are crucial, which makes a lot of sense. We did some extra bits 🧐 with GlycoShape ⬇️🧵

Super interesting work from @carolynbertozzi.bskyverified.social group about the effects of glycosylation in protein structure and function at the proteome scale 🤯💥🤩 Results show that sialylation and fucosylation are crucial, which makes a lot of sense. We did some extra bits 🧐 with GlycoShape ⬇️🧵

Carolyn Bertozzi@carolynbertozzi.bskyverified.social · 10mo ago

Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏 www.biorxiv.org/content/10.6...

Congratulations to my very good friend @jfhevler.bsky.social on this amazing pre-print on how mass-spec and MD simulation can enable functional analysis of protein glycoforms. It was a privilege to play a small part in this project and learn a lot from Johannes! #Glycotime #carbohydrate #Proteomics

Carolyn Bertozzi@carolynbertozzi.bskyverified.social · 10mo ago

Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏 www.biorxiv.org/content/10.6...

For those who perform thermal proteome profiling (TPP) experiments, you might find this new data analysis approach (and open source Python software) useful. Developed by postdoc @jfhevler.bsky.social 🙏 arxiv.org/abs/2508.096...

Thermal Tracks: A Gaussian process-based framework for universal melting curve analysis enabling unconstrained hit identification in thermal proteome profiling experiments

Thermal Tracks is a Python-based statistical framework for analyzing protein thermal stability data that overcomes key limitations of existing thermal proteome profiling (TPP) work-flows. Unlike stand...

arxiv.org

The liquid lectin array detects compositional glycocalyx differences using multivalent DNA-encoded lectins on phage by Guilherme Meira Lima, @RatmirDerda @derda_lab, et al. at @UAlberta @StanfordUChem @usponline http://dlvr.it/TGL3wR