RESEARCH @morignypauline.bsky.social @ondrej-kuda.bsky.social M Rohm (CAS, Helmholtz Munich) Multi-omics profiling of cancer cachexia models uncovers a multi-tissue coordinated response🧪

Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer - Nature Metabolism

Multi-omics profiling of diverse cancer cachexia models uncovers a multi-tissue metabolite-coordinated response associated with disease progression and links multi-tissue one-carbon metabolism to wasting.

dlvr.it

I am proud to share our multi-omics study in cancer cachexia out in @natmetabolism.nature.com 🦀 Through metabolomics, transcriptomics and glucose tracing of multiple cachexia target tissues, we uncovered a metabolic pathway with pro-cachectic potential.

Weight Loss in Cancer: New research led by #HelmholtzMunich shows that #cachexia affects multiple organs in a coordinated metabolic way, not just muscles. 👉 Read more: t1p.de/q0ukw @ondrej-kuda.bsky.social @iphys-cas.bsky.social @diabresearch-dzd.bsky.social @dzhk.de

New paper from our institute showing the importance of liver secretory function on the development of cancer cachexia. Congratulations to @dorie00.bsky.social , Sören Fisker Schmidt, Mauricio Berriel Diaz and Stephan Herzig ! Very proud to have contributed to this amazing story 🥳

Doris Kaltenecker@dorie00.bsky.social · last yr.

Excited to share that our study on the role of the liver in #CancerCachexia is out in Cell! 😀 🧬 We found that the liver plays an active role in driving weight loss in cancer through disruption of the circadian regulator REV-ERBα and secretion of catabolic hepatokines www.cell.com/cell/fulltex...

📣 Check out our recent preprint on bioRxiv on cellular changes in adipose tissue in response to different weight loss modalities 📣

Jesper Madsen@jespergrud.bsky.social · 2y ago

Preprint alert! We used snRNA-seq on adipose tissue from a longitudinal cohort of people undergoing surgury-induced weight loss. True ATLAS team effort We found dramatic changes in immune and progenitor compartments. Give it a read and let us know what you think. www.biorxiv.org/content/10.1...

Hi Bluesky ! 🦋