Thanks a lot to the organizers of ISCO ‘26 for a fantastic meeting and selecting me for best short talk ☺️. I had an amazing time! See you next year!
Moritz Bauer
@moritzbauer.bsky.social
Post-Doc @hubrechtinstitute.bsky.social @jopkind.bsky.social. PhD @crg.eu PayerLab. Epigenetics, the X and single-cell technologies.
Incredibly happy to be back in Barcelona to attend ISCO ‘26 to present our work on multiplexed single cell epigenomics!
It’s a wrap! 🎉 iDEMM 2026 is done — two days, 160 scientists, the most exciting embryo model science around. Less conference, more rock festival — just with pipettes instead of guitars. 🎸🔬 Huge thanks to speakers, posters, attendees, and my co-organizers @bracciolilab.bsky.social and Hendrik Marks.
Thrilled that our project received funding from the NWO Sustainable Science Fund! 🎉 We'll develop more sustainable single-cell epigenomic methods that cut plastic waste and energy use. www.nwo.nl/en/news/sust... @hubrechtinstitute.bsky.social @jopkind.bsky.social
Sustainable Science Fund; 20 projects granted funding to make research practices more sustainable | NWO
Research contributes to knowledge about sustainability, but how do we make research practices themselves more sustainable? Funding has been awarded to twenty projects from the call launched in 2025 by...
nwo.nl
Absolutely amazing place for a staff technician with tons of cool technologies! APPLY!
Robin H. van der Weide@robinhweide.bsky.social · 4mo ago💼 Hiring a Staff Technician at my Chromatin Systems Biology lab (UMC Utrecht). A wet lab role with real ownership: co-develop research lines, contribute to publications, build something from the ground up. Permanent position, pending tenure. Details & apply:
Don’t forget to sign up — registration is still open for the International Dutch Embryo Model Meeting 2026 in Utrecht (7–8 May)! 🚀 Hope to see many of you there. Registration closes 24 April!
Moritz Bauer@moritzbauer.bsky.social · 6mo ago🧬 We are excited to announce the INTERNATIONAL DUTCH EMBRYO MODEL MEETING 2026 — Engineering the Origins of Life 📅 7–8 May 2026 📍 Utrecht, The Netherlands Register & submit abstracts: www.oncodeinstitute.nl/internationa...
Don’t forget to sign up — registration is still open for the International Dutch Embryo Model Meeting 2026 in Utrecht (7–8 May)! 🚀 Hope to see many of you there. Registration closes 24 April!
Luca Braccioli Lab @ UU@bracciolilab.bsky.social · 6mo ago🧬 We are excited to announce the INTERNATIONAL DUTCH EMBRYO MODEL MEETING 2026 — Engineering the Origins of Life 📅 7–8 May 2026 📍 Utrecht, The Netherlands Register & submit abstracts: www.oncodeinstitute.nl/internationa...
🧵 CTCF is essential for embryonic development, but why has remained unclear. By combining gastruloids with a temporal degron system, we uncovered a surprising dual function — and it changes how we think about CTCF's role in development. 1/8 www.biorxiv.org/content/10.6...
A dual role for CTCF in development
CTCF is an essential DNA binding protein whose absence leads to embryonic lethality. CTCF is primarily known for its role in 3D genome organization where its N-terminal domain interacts with cohesin to anchor chromatin loops. How CTCF facilitates proper embryonic development remains unclear, necessitating temporal control to resolve its stage-specific functions. By combining gastruloids, an in vitro model of embryonic development, with a degron system to rapidly deplete CTCF at defined timepoints, we show that early CTCF depletion impairs early gastruloid morphogenesis. Surprisingly, ATAC-seq and time-resolved RNA-seq revealed that differentiation was unaffected. CTCF binding is strongly enriched at promoters of downregulated genes. Re-expression of a CTCF variant with an N-terminal truncation, incapable of looping, was sufficient to rescue the expression of CTCF-promoter bound genes and the defects in morphogenesis. However, extended culture (up to 168 hours) of gastruloids reconstituted with N-terminal truncated CTCF led to their collapse. Our work shows that CTCF has a dual function in early mammalian development: at early stages CTCF regulates developmentally important genes through promoter binding, while at later stages its looping function is required for correct development. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, https://ror.org/0472cxd90, 637587, 865459 Dutch Research Council, https://ror.org/04jsz6e67, 016.161.316, VI.C.222.049 Dutch Cancer Society, https://ror.org/0368jnd28, N/A
biorxiv.org
🧬 We are excited to announce the INTERNATIONAL DUTCH EMBRYO MODEL MEETING 2026 — Engineering the Origins of Life 📅 7–8 May 2026 📍 Utrecht, The Netherlands Register & submit abstracts: www.oncodeinstitute.nl/internationa...
We are hiring! Looking for curious and motivated new colleagues to join my lab at the Karolinska Institute @ki.se. If you are interested in studying cell identity and pancreas biology using human organoids, (spatial)omics genome and bioengineering please reach out! #hiring #sciencejob #STEMJobs
Big congrats Robin! So well deserved ☺️ Looking forward to our collabs
Robin H. van der Weide@robinhweide.bsky.social · 7mo ago🌱 As of Jan 1, I started as Assistant Professor at UMC Utrecht – Center for Molecular Medicine. Very grateful to @dewitlab.bsky.social and @jopkind.bsky.social and to the many other people who supported me along the way. I’ll be launching the lab soon, focusing on Chromatin Systems Biology.
1/ 🧬 Very excited to share our work on dissecting imputation strategies for single-cell histone modification data! academic.oup.com/nargab/artic... A huge thank you to @robinhweide.bsky.social, @jopkind.bsky.social and Jeroen de Ridder for their collaboration in this project!
Using fluorescence live imaging and an in vitro implantation model, we show that human embryo attachment begins with direct cell fusion via syncytin-2–MFSD2A interaction. With @hansclevers.bsky.social. Great work by @tnoordzij.bsky.social & @martinacelotti.bsky.social www.biorxiv.org/content/10.6...
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you. More info: www.crg.eu/en/content/t...
Great place for a PhD with one of the smartest minds in the field!
Matthias Muhar@matthiasmuhar.bsky.social · 10mo agoFascinated by protein homeostasis, stem cells and development? I am recruiting PhD candidates through the fabulous IMPRS-CellDevoSys program. This place is buzzing with great science and brilliant minds. Come join!
Great PhD opportunity with a fantastic mentor!
Max Planck Institute of Molecular Cell Biology and Genetics@mpi-cbg.de · 10mo agoAre you interested in a PhD in the area of "Mechanisms of translational control during embryogenesis?" Apply now for a PhD @mpi-cbg.de! Overview of all participating RGLs: imprs.mpi-cbg.de/5761/researc...
1/ 🧵 I am excited to share a new preprint from our group: Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes. doi.org/10.1101/2025... #Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social
MeCP2 binding and genome–lamina reorganization precede long gene activation during mouse corticogenesis
During corticogenesis, neural gene expression is tightly coordinated by chromatin and epigenetic changes, whose misregulation can lead to neurodevelopmental disorders[1][1]–[4][2]. The role of spatial...
doi.org
Finally out on @devbiol.bsky.social: we find that Epop mutant mice have near-perfect Polycomb phenotype (orderly posterior shift of vertebral identity🩻) linked to accelerated HOX clock⏰. Bonus: Epop has maternal effect! Study co-led by the the labs of Bernie Payer and @lucianodicroce.bsky.social
The PRC2-associated factor EPOP is required for Hox gene regulation during axial development in mice
The Polycomb repressive complex 2 (PRC2) is an essential modulator of gene repression. We previously reported that, in mouse embryonic stem cells, PRC…
sciencedirect.com
Great use of DamID to use it as a history tracing tool!
Taro Kitazawa@kitazawa-taro.bsky.social · 12mo agoPlease RP. We are thrilled to announce that our lab’s first preprint is out! ”Whole-genome single-cell multimodal history tracing to reveal cell identity transition” We report HisTrac-seq, a multiomic single-cell molecular recording platform. www.biorxiv.org/content/10.1...
I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....
Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation - Nature Cell Biology
Kefalopoulou, Rullens et al. develop Dam&ChIC to assay chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division a...
nature.com
Great new paper from the lab highlighting the utility of multimodal single-cell readouts!
Jop Kind @jopkind.bsky.social · last yr.I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....
🧬 Looking for a PhD position in molecular or developmental biology? 🔬 ✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/
🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰). Come work in our collaberative team of top scientists shorturl.at/avBBy
Postdoctoral Researcher - Computational modeling of Epigenetic Inheritance - 38 hours p/w - Hubrecht Institute
About the Project Faithful inheritance of the epigenome in proliferating cells critically underpins human development and health. While DNA replication fidelity and DNA mutation rates are well underst...
shorturl.at
🚨 Paper Alert 🚨 I'm incredibly proud and excited to announce that our latest research on the chromatin regulatory profile of gastruloids has been published in @DevCell! 🎉 Check out the full paper here: www.cell.com/developmenta... @dewitlab.bsky.social , @bracciolilab.bsky.social 🙌 🧵👇
Identifying cross-lineage dependencies of cell-type-specific regulators in mouse gastruloids
Braccioli et al. use time-resolved single-cell chromatin accessibility analysis to study mouse gastruloid development. They identify key transcription factors driving mesoderm and spinal cord differen...
cell.com
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...
PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n
bioRxiv Genomics@biorxiv-genomic.bsky.social · last yr.CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays https://www.biorxiv.org/content/10.1101/2025.02.03.636299v1
A new review from our group on the implementation of single-cell epigenomics in cancer research. A hitchhiker's guide for the use of both wet- & drylab methods. A big shout-out to Marta and Isabel! doi.org/10.1002/ijc....
A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research
Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored....
doi.org
📢 Save the date! We are excited to announce the International Dutch Embryo Model Meeting 2025 in Nijmegen (NL) on Thursday 27 March and Friday 28 March! Registration is open now. More information: ru.nl/en/about-us/... Big thanks to Hendrik Marks for taking the lead this time!
I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...
