IAPEz retrotransposons regulate the first lineage segregation in mouse pre-implantation development academic.oup.com/nar/article/...

IAPEz retrotransposons regulate the first lineage segregation in mouse pre-implantation development

Abstract. Transposable elements (TEs) comprise nearly half of mammalian genomes and drive species-specific regulatory innovation, but their contributions t

academic.oup.com

H2A.Z facilitates Sox2-nucleosome interaction by promoting DNA and histone H3 tail mobility academic.oup.com/nar/article/...

H2A.Z facilitates Sox2-nucleosome interaction by promoting DNA and histone H3 tail mobility

Abstract. Epigenetic regulation of chromatin structure is strongly influenced by histone variants and post-translational modifications. The conserved histo

academic.oup.com

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

How much of Thermo Fisher’s antibody data has been manipulated?

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

reeserichardson.blog

So proud of Buffalo right now. ❤️🇨🇦🇺🇸

CJ Fogler@cjzero.bsky.social · 3mo ago

Via Sportsnet

@zebrafishrock.bsky.social I’m looking for a lab-raised pathogen free source for a zebrafish Danio Rerio sibling species like kyathit or aesculapii. Could you please broadcast?

i firmly believe that kennedy wants preventable diseases to rip through american communities since, in his warped mind, those who survive without vaccines will have proven themselves “healthy.”

The UnPopulist@theunpopulist.net · 4mo ago

Kennedy canceled $500 million in mRNA research and announced no new mRNA projects will ever be initiated—killing the technology that produced the fastest vaccine rollout in human history.

An mRNA treatment for PANCREATIC CANCER was in trials, among many other uses. Choosing to end this research is choosing to sentence millions to an early, painful death

The UnPopulist@theunpopulist.net · 4mo ago

Kennedy canceled $500 million in mRNA research and announced no new mRNA projects will ever be initiated—killing the technology that produced the fastest vaccine rollout in human history.

Very interesting new preprint from Patrick Murphy's group @pjmurphy249.bsky.social, finding that intergenic Pol II binding before zygotic genome activation is connected to repetitive element transcription. www.researchsquare.com/article/rs-9...

So proud of Dr. Duy Nguyen and his successful thesis defense!! Congrats Duy!

Today’s guest: Patrick Murphy podcasts.apple.com/us/podcast/e...

From Placeholder Nucleosomes to Zygotic Genome Activation (Patrick Murphy)

Podcast Episode · Epigenetics Podcast · February 26 · 39m

podcasts.apple.com

Pauli Group (posts by Andi Pauli)@pauligroup.bsky.social · 5mo ago

Join us in Vienna for the biggest international 'FISH' meeting in 2026! No matter which fish is your favorite model - zebrafish, medaka, killifish, cavefish, Danionella, cichlids, stickleback, you name them...- this meeting is for you! www.ezm2026.org Abstract submission deadline is March 15th.

I always say… “the data’s the data’s the data…” you can only interpret it and can’t change it.

Itai Yanai@itaiyanai.bsky.social · 6mo ago

The 3 hardest things to learn as a scientist: 1. Trust the data.. especially when it’s not what you expected, 2. Trust the data.. allowing it to change your direction, 3. Trust the data.. but not too much: test with new data at every turn.

The 3 hardest things to learn as a scientist: 1. Trust the data.. especially when it’s not what you expected, 2. Trust the data.. allowing it to change your direction, 3. Trust the data.. but not too much: test with new data at every turn.

Itai Yanai@itaiyanai.bsky.social · last yr.

90% of doing science is being open to new ideas.

Researchers working on model organisms don’t do it for funzies. It’s because the questions they ask are important and can’t be solved using mouse, or human cell culture systems. Notice: This message is especially intended for journal editors.

This water fountain distributes polycomb

When postdocs and grad students move on, I don’t worry about “losing” projects. If a postdoc wants to extend their work beyond my lab, my answer is yes. They should take their momentum with them. I have plenty of ideas, and there will always be more questions to ask.

I cannot emphasize this enough, if you're cold-emailing me applying to my lab I would so much rather get the bulleted broken list of genuine interests than whatever letter ChatGPT spits out in its stead If you're training with me, I'm working with you not an LLM. I want to see who you are!

Great advice received as a postdoc: Do the easiest thing. I was 3 years into my postdoc and juggling projects w/nothing concrete = career crisis I went to my advisor Paul Sternberg for help. He asked what was going on & what mutant had the strongest phenotype. "Clone the easiest one." It worked.

Arjun Raj@arjunraj.bsky.social · 7mo ago

Blog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it. open.substack.com/pub/arjunraj...

Fire Ring Danio

So excited to finally share my recent work on sex differences in crossing over using mice from diverse genetic backgrounds! www.biorxiv.org/content/10.6...

Chromosome length is not the sole determinant of sexually dimorphic crossover rates during mammalian meiosis: Insights from genetically diverse mouse strains

Meiotic recombination generates crossovers (COs), reciprocal exchanges between homologous chromosomes critical for accurate chromosome segregation. Inappropriate CO frequency and distribution drive an...

biorxiv.org

Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...

Maybe I should teach this and an alternative “modern” perhaps even “Gen Z” definition of epigenetics next semester.

Jessica Tollkuhn@tollkuhn.bsky.social · 8mo ago

absolutely losing it at my 14yo's biology homework

A tiny trial in New York has shown that personalized mRNA vaccines can provoke massive, lasting immune responses against pancreatic cancer, even as sweeping federal cuts now threaten the fragile labs required to produce them. theintellectualistofficial.substack.com/p/a-breakthr...

I still receive email inquires about postdoc jobs in my lab, with generic cover letters from applicants who don’t seem to be genuinely interested in our research… please save everyone time and read this article before emailing PIs: network.febs.org/posts/consid...

Considering a postdoc? Read this first

Looking for your first postdoctoral position can be confusing but being proactive, and focusing on your research interests and career goals can help. This useful post from a recent postdoctoral fellow...

network.febs.org

Any recommendations on getting a journal editor to respond to an email? Desk rejection is taking longer than peer review these days, and I don’t seem to get any response emails back from editors.

Excited to announce that our peer-reviewed manuscript is online in the Development journal @dev-journal.bsky.social. The manuscript was much improved through the peer-review process, and I am grateful to the reviewers for their valuable feedback. journals.biologists.com/dev/article/...

Feed-forward loops by NR5A2 ensure robust gene activation during pre-implantation development

Pioneer transcription factors are crucial for regulating zygotic genome activation and cell differentiation during mouse pre-implantation development. However, how pioneer factors function collectivel...

journals.biologists.com

After my first semester teaching Genetics to 250+ Cornell undergrads, I’m surprised to find that the classroom has become my happy/safe space…

The December cover of Genome Biology and Evolution features Rojas-Triana et al., who publish a Review on the adaptive potential of extrachromosomal circular DNA across taxa. 🔗 doi.org/10.1093/gbe/evaf223 #genome #evolution

Pls Repost: I am putting together an edition of “Methods in Molecular Biology” focused on early development, encompassing gastrulation. I am making a list of potential authors for chapters. If interested, please contact me - An excellent opportunity for trainees to co-author with their advisors.

Check it out: New tech can unlock mysteries of genome’s hidden half news.cornell.edu/stories/2025...

New tech can unlock mysteries of genome’s hidden half | Cornell Chronicle

Cornell researchers have found that a new DNA sequencing technology can be used to study how transposons move within and bind to the genome.

news.cornell.edu