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Moritz Treeck

@moritztreeck.bsky.social

Cell Biology of Host-Pathogen interaction @work (www.gimm.pt) in Oeiras/Lisbon ; enjoying sun and sea in Portugal when not @work www.treecklab.org https://gimm.pt/lab/moritz-treeck-lab/

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Moritz Treeck@moritztreeck.bsky.social · last yr.

A common virulence factor that protects Toxoplasma (and probably related parasites) from clearance in genetically diverse murine hosts. A heroic CRISPR screening effort from @fratorelli.bsky.social with some help from colleagues. Thanks to anonymous reviewers for some good suggestions. 1/2

Francesca Torelli@fratorelli.bsky.social · last yr.

🎉 Finally online 🎉 GRA12, the first identified common virulence factor across Toxoplasma strains and murine subspecies! Check this improved manuscript after reviewers’ helpful suggestions www.nature.com/articles/s41...

Georgia Walton@drgeorgiawalton.bsky.social · last yr.

I am beyond excited to share that you can now apply to observe a @wellcometrust.bsky.social #DiscoveryResearch shortlisting Committee! If you plan to apply to us in the next 2 years, apply to be an Observer now to better understand what happens once you click submit! wellcome.org/grant-fundin...

Apply to observe a Wellcome funding advisory committee | Prepare to Apply | Wellcome

Find out how to observe a Wellcome funding advisory committee. Researchers who are considering applying for Wellcome funding in the next two years can apply to observe a shortlisting committee.

wellcome.org

Karina Xavier Lab@karinaxavierlab.bsky.social · last yr.

Host-Microbe Symbioses- Our favorite summer school is back! Help us spread the word!

The Symbiosis Courses Alumni Network@symbiosisalumni.bsky.social · last yr.

Save the date 📅: The PhD Summer School on Host-microbe Symbioses is taking place from 6-19 of July in Oeiras, Portugal. Registration is opening soon! Learn more 👉 gimm.idloom.events/phd-summer-s... @gimmfoundation.bsky.social @moorefound.bsky.social @crc1182.bsky.social #CIFAR #CBR

Theo Sanderson@theo.io · 2y ago

🎺 PhD studentship available at @lshtm.bsky.social and RVC! @influenzal.bsky.social and I are advertising for a project to investigate the unexpected phenomenon that mutagenic antiviral drugs can give rise to viruses with hundreds of mutations which are still viable. 🧵 www.lshtm.ac.uk/study/fees-a...

2025-26 Bloomsbury Colleges PhD Studentships | LSHTM

The Bloomsbury Colleges group was set up in 2004 and consists of five institutions: Birkbeck, London School of Hygiene & Tropical Medicine (LSHTM), the Royal Veterinary College (RVC), the School of Or...

lshtm.ac.uk

Moritz Treeck@moritztreeck.bsky.social · 2y ago

Credit goes to the fabolous current and past lab members @fratorelli.bsky.social, Diogo da Fonseca, @simon-butterworth.bsky.social and @youngtoxolab.bsky.social

Moritz Treeck@moritztreeck.bsky.social · 2y ago

The hypothesis for this work was formed when we expectedly observed some Toxoplasma mutants with known fitness defects not showing defects in in vivo CRISPR screens. The results indicate that CRISPR screens can miss important virulence factors through paracine effects that function in the host.

Moritz Treeck@moritztreeck.bsky.social · 2y ago

The hypothesis for this work was formed when we expectedly observed some Toxoplasma mutants with known fitness defects not showing defects in in vivo CRISPR screens. The results indicate that CRISPR screens can miss important virulence factors through paracine effects that function in the host.

eLife@elife.bsky.social · 2y ago

In Toxoplasma gondii, a parasite infamous for manipulating the behaviour of its hosts that infects an estimated ⅓ of humans, genetic defects are rescued if co-infected with normal parasites, thanks to supportive secreted proteins. https://buff.ly/3BtpD86

A cyst containing Toxoplasma gondii in mouse brain tissue. Thousands of resting parasites (stained red) are enveloped by a thin parasite cyst wall.
Moritz Treeck@moritztreeck.bsky.social · 2y ago

Congrats to Catarina Rosa in the lab for securing an EMBO fellowship! Perfect timing for the xmas party with my amazing, creative team! We are looking forward to a new year full of exciting host-pathogen biology discoveries (whilst enjoying life)!

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Moritz Treeck@moritztreeck.bsky.social · 2y ago

Congrats Bishara and team @saterialelab.bsky.social to this wonderful piece of work! Essential read for all those that have not heard about it yet and are interested in host-pathogen interaction.

bishara marzook@ghostpathogen.bsky.social · 2y ago

Have you ever wondered how knocking out every single gene in the human genome, one by one, might affect your intracellular pathogen of interest? We did, & boy was it a wild ride! Happy to share our preprint discovering the essential host genome for Cryptosporidium - www.biorxiv.org/content/10.1...

Schematic showing the experimental outline for a full genome arrayed CRISPR screen. 384-well plates containing cells with an arrayed crRNA library are infected with Cryptosporidium parasites, which undergo asexual rounds of replication intracellularly, followed by sexual development to male and female forms. Plates are then fixed and immunolabeled to detect all parasites, female parasites, host actin recruited to parasite vacuoles, and host nuclei. Three z-stacks were imaged by high content microscopy to detect apically located parasites as well as host cell actin and nuclei.
Wellcome Trust@wellcometrust.bsky.social · 2y ago

Are you looking for fungi funding? 🍄 We’re offering up to £3 million per award to research how fungi adapt to their environment. Understanding this could have powerful benefits for human life and health. Apply by 28 January ⤵️ wellcome.org/grant-fundin...

Fungal adaptation | Grant Funding | Wellcome

This award will fund research on the mechanisms and triggers for fungal adaptation. Find out eligibility, what's in scope and how to apply.

wellcome.org