www.cell.com/molecular-ce... check this beautiful paper

Alu repeat-containing RNAs spatially organize actively transcribed genomic regions around nuclear speckles

Liu et al. identify nuclear speckle-enriched Alu repeat-containing RNAs that facilitate the organization of actively transcribed genes at speckles by binding Alu sequences and promoting speckle assemb...

cell.com

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab. @mrclmb.bsky.social Please get in touch if you have any questions. www.nature.com/naturecareer...

Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Cambridge, Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12854636

Research Group Leader Tenure Track Starting Salary £67,979 to £76,868 per annum MRC Laboratory of Molecular Biology, Cambridge, UK The MRC Laborato...

nature.com

Sjors Scheres@sjorsscheres.bsky.social · 6mo ago

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.

🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜 www.science.org/doi/epdf/10....

Michelle Percharde@mpercharde.bsky.social · 2y ago

Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)

Very excited to be part of this prestigious programme, thank you @embo.org !

MRC Laboratory of Medical Sciences@mrc-lms.bsky.social · 8mo ago

Congratulations to LMS group head @mpercharde.bsky.social who has been selected as one of this year’s EMBO Young Investigators! 🌟 The prestigious EMBO Young Investigator Programme supports exceptionally talented life scientists who represent innovation and excellence in their fields. @embo.org

Congratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome! Read the press release here: https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/

🚨Post open in our lab! Come work on some cool themes involving metabolism, chromatin, early development 🤓. Pls RT

Bryony Leeke@bryonyleeke.bsky.social · 8mo ago

Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.

📣 We’re hiring 6 new Team Science postdocs! Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone. Find out more and download our brochure below

MRC Postdoctoral Research Scientists x 6 - MRC Laboratory of Medical Sciences

Team Science Project

lms.mrc.ac.uk

#TEsky

Nature Cell Biology@natcellbio.nature.com · 9mo ago

☕ @katerinakraft.bsky.social @sedonamurphy.bsky.social @mattjones.bsky.social et al. identify extrachromosomal DNA(ecDNA)-interacting elements (EIEs) enriched for #TransposableElements in #ColorectalCancer. EIE 14 integrated within ecDNA acts as an enhancer to promote cancer fitness. bit.ly/49iFC7C

Register now for our one-day symposium at the MRC Laboratory of Medical Sciences on environmental and metabolic control of early development on 4 December 2025! Spaces are limited, register here: www.symposia.org.uk/courses/stem...

Spaces filling up for our @bsdb.bsky.social GRT symposium @mrc-lms.bsky.social on environment, metabolism and stem cell development 4th Dec 2025! Updated poster with talk titles below. Register here: www.symposia.org.uk/courses/stem... Looking forward to seeing you there!

Michelle Percharde@mpercharde.bsky.social · last yr.

🚨Symposium alert! 🚨 Next edition of our biennial stem cell symposium is 4th Dec 2025 - focus on metabolism and development. Sponsored by @bsdb.bsky.social. Great lineup of speakers, hosted @mrc-lms.bsky.social in London. Registration is open. www.symposia.org.uk/courses/stem...

We are launching 11 new #PhD opportunities today! If you would like to contribute to the research at the LMS apply today! #medicalscience #lifescience

Studentships and PhD training

We have two core PhD programmes - traditional and transdisciplinary. Our PhD students are registered with Imperial and are embedded in our dedicated research facility.

lms.mrc.ac.uk

We have a new PhD studentship in the lab on the immunogenic roles of transposable elements in paediatric acute myeloid leukaemia! Come and work with us! www.colcc.ac.uk/2026-cyp-phd...

2026 CYP PhD Project Deniz

Uncovering the Immunogenic Landscape of Transposon-Driven Transcripts in Paediatric Acute Myeloid Leukaemia Primary supervisor: Özgen Deniz, Queen Mary University of London Secondary supervisor: Ri...

colcc.ac.uk

Cancer Research UK City of London Centre@cruk-cityoflondon.bsky.social · 10mo ago

Are you interested in doing a #PhD in #cancerresearch? 🧪🧑‍🔬👨🏽‍🔬👩🏿‍🔬🧫🦠🔬 Do you want to develop new #biotherapeutics? Find cancer cures for #youngpeople? Applications for our fully funded 4-year PhD programme starting in Autumn 2026 are open! bit.ly/4mHbPIH #uclcancer #QMBCI #KCLcancer_pharm #KCL #TheCrick

World’s first AI-designed viruses a step towards AI-generated life. #Nature Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria. www.nature.com/articles/d41...

World’s first AI-designed viruses a step towards AI-generated life

Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.

nature.com

Come be our head of bioinformatics at @mrc-lms.bsky.social ! Our bioinformatics team are closely involved with lots of interesting science and we love working with them. Topics inc. development, cancer, metabolism, aging, TEs (my favourite of course 😜) #TEsky lms.mrc.ac.uk/work/vacanci...

Head of Bioinformatics - MRC Laboratory of Medical Sciences

We are recruiting for a Head of Bioinformatics to lead our Bioinformatics facility

lms.mrc.ac.uk

it appears your low-hanging-fruit phd project wasn't so risk free after all, mr. bond

Join the #LMS! Our institute is advertising for junior #GroupLeader positions in #Physiology and #Metabolism. Closing date for applications: August 31st!

MRC Laboratory of Medical Sciences@mrc-lms.bsky.social · last yr.

📢 We have PLT openings! If you carry out ambitious research in an area relevant to Human Metabolic Disease then get in touch! We are especially interested in research focused in Metabolic Physiology using murine and/or human in vivo models and Immunometabolism. Apply now!

A new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue. A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.

Study reveals the hidden benefits of weight loss on fat tissue

Scientists from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have produced the first detailed characterisation of the changes that weight loss causes in human fat tissue by...

lms.mrc.ac.uk

🚨Symposium alert! 🚨 Next edition of our biennial stem cell symposium is 4th Dec 2025 - focus on metabolism and development. Sponsored by @bsdb.bsky.social. Great lineup of speakers, hosted @mrc-lms.bsky.social in London. Registration is open. www.symposia.org.uk/courses/stem...

Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social

The Chromatin And Development lab are hiring a postdoc! Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT! lms.mrc.ac.uk/work/vacanci...

MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences

The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...

lms.mrc.ac.uk

LTRs as dogs…can be friendly, quite helpful at times. LINEs as cats? Also pretty nice in some cases, but also will get angry and scratch out your eyes. Hmm #TEsky 🤔

Annika Barber@annikabarber.bsky.social · last yr.

I love the concept of domesticated transposable elements. I like that my genome has its little viral pets to feed nucleic acids and take out for transcriptional walkies. 🧬

I love the concept of domesticated transposable elements. I like that my genome has its little viral pets to feed nucleic acids and take out for transcriptional walkies. 🧬

In this Review, @bryonyleeke.bsky.social, Imke Staffhorst and @mpercharde.bsky.social @mrc-lms.bsky.social explore roles of the nucleolus in mammalian development, focusing on genome organisation and chromatin regulation: doi.org/10.1242/dev....

The nucleolus....large, rather boring organelle in the nucleus? No! Our review led by @bryonyleeke.bsky.social just out @dev-journal.bsky.social, highlighting new findings on nucleoli dynamics in development, intriguing roles in chromatin organisation & more. journals.biologists.com/dev/article/...

Calling undergrads! Our summer internship programme @mrc-lms.bsky.social is still open if you want to try out a summer research project. Great way to get a taste of research, inc a generous stipend. Lots of interesting labs are hosting, including us ;) Closing 15/5/25. lms.mrc.ac.uk/work-and-stu...

LMS Undergraduate Summer Programme - MRC Laboratory of Medical Sciences

Our LMS Undergraduate Summer Programme is a fantastic, fully-funded opportunity for undergraduate students to gain hands on laboratory experience to support their scientific journeys.

lms.mrc.ac.uk

I am excited to share our lab's first review out with in Blood Cancer Journal. We discuss the impact of transposable elements on genome regulation and variation in both normal haematopoietic processes and haematological cancers. www.nature.com/articles/s41...

Transposable elements as genome regulators in normal and malignant haematopoiesis - Blood Cancer Journal

Blood Cancer Journal - Transposable elements as genome regulators in normal and malignant haematopoiesis

nature.com

🚨🚨#Hiring! 3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG 📆 Apply by 23rd May 2023 🔗Details below @sebioldev.bsky.social Please RT!🙏

Barbara McClintock proposed – over 40 years ago – that transposable element activity could be a response to stress, and I think that we are still only beginning to understand how right she was.