Mill_lab
@cilialab.bsky.social
Group at MRC HGU using genetics, cell biology and lots of imaging to unlock the mysteries of mammalian #cilia. #cilia. #centrioles #cytoskeleton #RareDisease www.cilialab.co.uk
The OpenAI suit reinforces my view that there are two LLM genders: ChatGPT and Claude. Apple is very Claude. In this schematic, xAI is the incel in the corner, Meta is the 5’7” ChatGPTlet in the corner insecure about its ChatGPT-sculinity. Google is Claude-passing ChatGPT. Microsoft is ChatGPT lite.
New paper from the @xionglab.bsky.social and Mogessie labs at Yale! We uncover the molecular architecture of mammalian oocyte cytoplasmic lattices (CPLs), revealing GTP-bound tubulin associated with a degradative protein complex. Read the paper: doi.org/10.1038/s415...
Cytoplasmic lattices store developmentally poised degradative and cytoskeletal complexes in mammalian eggs - Nature Structural & Molecular Biology
Li et al. obtain high-resolution, native structures revealing that cytoplasmic lattices in mammalian eggs organize and store degradative and cytoskeletal complexes for early embryonic development.
doi.org
Seems fair enough 😂 “To build one affordable house” - beats Nigel’s record
I know this is daft, but it actually serves a purpose. It helps to 'weirdify' fascism, puncturing the narrative they want to create that their victory is inevitable and 'normal'. bsky.app/profile/ianf...
Ian Ford 🇪🇺 🇺🇦@ianford.bsky.social · 4w agoThe surreal news of Nigel Farage's desperate stunt to avoid scrutiny for his financial deals backfiring and now having to fight an election campaign against Count Binface is what @jenmercieca.bsky.social would say is a way to weirdify fascism. It destroys the myth of their omnipotence.
In case you missed it, here's Count Binface's appearance on the BBC this morning.
Does every enhancer work with every promoter? With @jengreitz.bsky.social and Will Greenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field. A tour 🧵👇 www.biorxiv.org/content/10.6...
Intrinsic promoter responsiveness dictates sensitivity to transcriptional activation by enhancers
Enhancers activate specific target promoters, but whether intrinsic enhancer-promoter compatibility contributes to this specificity is debated. Recent studies using different reporter assays have reac...
biorxiv.org
😮 @danielgorelick.bsky.social @biologyopen.bsky.social www.nature.com/articles/d41...
Why paying peer reviewers works, according to a journal’s editor-in-chief
A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.
nature.com
Also in Issue 12: - Editorial from Megan King @luskinglab.bsky.social & @abbybuch.bsky.social - Cell scientist to watch interviews with @andrewdstephens.bsky.social & @katemiro.bsky.social - Perspectives on chromatin dysfunction & cancer and nuclear lipids journals.biologists.com/jcs/issue/13...
Hey #nucleus nerds, the JCS Special Issue on the Cell Biology of the Nucleus is now live! This was a pleasure to co-edit with Megan King @luskinglab.bsky.social.
Journal of Cell Science@jcellsci.bsky.social · last mo.Our Special Issue: Cell Biology of the Nucleus is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows the posteriorly positioned nuclei (Nup50-mCherry - pink) of notochord cells in Ciona embryos. See article by Peng et al. journals.biologists.com/jcs/article/...
Last Friday, we wrapped up #EESMechanobiology 🧪 Thank you to our participants, speakers, and organisers for making this symposium a success. Together, we explored how new technologies and approaches are advancing mechanobiology across biological systems. We're looking forward to the next edition!
Our new paper in @plosbiology.org introduces IntAct-U-ExM enabling isoform-specific imaging of actin at nanoscale across yeast, mammalian cells & primary neurons. Fabulous work spearheaded by @anubhavdhar.bsky.social along with an amazing team! #actin #U-ExM journals.plos.org/plosbiology/...
Every 3D tissue is a map waiting to be drawn. Flatten a curved tissue, follow how it deforms, find its hidden axis, or measure its shape to explain how it moves: it's all cartography!
New preprint! In collaboration with @xujwet.bsky.social, @pedrobeltrao.bsky.social, and Akhmanova and Beekman groups, we determined the structure of the transition zone microtubule doublet in mammalian motile cilia, providing potential insights into the regulation of IFT: tinyurl.com/fssnevuc
Structure of the mammalian ciliary transition zone microtubule doublet
The ciliary transition zone gates bidirectional protein trafficking to maintain the specialized ciliary proteome using microtubule doublets as a scaffold. While ciliary axonemal doublets are well-char...
tinyurl.com
Starting to write up the first mechanistic paper from my lab about regulation of endosomal PI(3)P. We see retromer tubules (Vps35) budding from PI(3)P positive sorting endosomes with Actin at the neck. When PI(3)P homeostasis is perturbed this organisation breaks down and cells cant recycle cargo.
Cilia and Centrosome 2026 Meeting Update: We have extended the abstract deadline until June 23! Submit yours today to join a fantastic scientific program!
There are lots of exciting opportunities to join the in situ structural biology community at Leeds this Autumn - 2 studentships in the Cheney PhD program (astbury.leeds.ac.uk/cheney-phd/) and I am recruiting a PhD student and research assistant. Please share and send any future tomographers our way!
Cheney Scholarship PhD Programme : The Astbury Centre for Structural Molecular Biology - "Understanding Life in Molecular Detail"
Applications are open for 2 PhD student places. Closing date for applications is Thursday 26 June, 5pm. Interviews will be held on 9th July 2026. The Cheney Scholarship is a prestigious 4-year PhD pr...
astbury.leeds.ac.uk
Vertebrate #Hedgehog signaling is transduced by transmembrane protein Smoothened (SMO) on the primary #cilium, but what is its mechanism? @reitergroup.bsky.social &co show that SMO & ciliary GPCRs regulate ciliary PKA activity to activate the Hedgehog pathway @plosbiology.org 🧪 plos.io/4v7vdnp
Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
It won’t take you years to publish your work in JCS: most articles go from submission to acceptance in under 5 months. We also show a strong commitment at first decision, with over 95% of revisions being accepted. Find out more: journals.biologists.com/jcs/pages/re... #forscientistsbyscientists
If you need another reason to use proteomics to quantify proteins rather than Western Blot:
Reese Richardson@reeserichardson.bsky.social · 2mo agoThe Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
1 week to start🔥 New @focalplane.bsky.social webinar series focused on #CellMigration, register & join us▶️, it will be fun! pls spread the word, in the next one, ECRs could apply to show their work ;) ▶️ to register: focalplane.biologists.com/2026/05/29/n... @dgz.bsky.social @the-node.bsky.social
Microtubules (green) fighting retrograde actin flow (magenta) in a neuronal growth cone videoed through a TIRF microscope. #CellBiology
Paying peer reviewers works. Expanded Fast & Fair experiment @biologyopen.bsky.social: • 5.5 vs 37.7 working days to decision with reviews • ~3 vs ~9 reviewer invitations per manuscript • no reduction in editor-assessed review quality • similar acceptance rates www.biorxiv.org/content/10.6...
The peer-review system needs an update. Biology Open did a cool experiment - contract reviewers in advance, and compensate them for a job well done. The results: it accelerates the process without loss of quality! Very promising. It’s not like for-profit journals can’t afford it…
Daniel Gorelick@danielgorelick.bsky.social · 2mo agoPaying peer reviewers works. Expanded Fast & Fair experiment @biologyopen.bsky.social: • 5.5 vs 37.7 working days to decision with reviews • ~3 vs ~9 reviewer invitations per manuscript • no reduction in editor-assessed review quality • similar acceptance rates www.biorxiv.org/content/10.6...
Our paper is out in Developmental Biology! It's part of a special issue on Forebrain Development. Mouse KO of Togaram1, a Joubert Syndrome gene, has defects in forebrain morphogenesis and neurogenesis. 🐭🧠🧪 #cilia #devbio #cellbio www.sciencedirect.com/science/arti...
Microtubule binding protein Togaram1 is required for proper development of mammalian forebrain and neural primary cilia
Proper forebrain development relies on precise spatial and temporal control of early neural stem cell (NSC) proliferation and later neurogenesis. Brai…
sciencedirect.com
NEW PREPRINT ALERT (shameless plug: www.biorxiv.org/content/10.6...) We’ve all been there: Sitting in a cell biology talk when suddenly— cytoskeleton fireworks EB1-GFP comets streaking across the screen. Tiny glowing microtubules everywhere. Absolute cinema.
Still time to register to join us next Friday in Leeds for our annual in-person UK Cilia and Centrosome Network in Leeds (05/06/2026)! Keynotes from the amazing @helenfoster.bsky.social & Fanni Gergely, plus latest breaking #cilia & #centrosome science. Register: www.eventbrite.co.uk/e/uk-cilia-c...
UK Cilia & Centrosomal Network Meeting Spring Meeting 2026
Join us for the annual in-person meeting of the UK Cilia & Centrosomal Network meeting, which for 2026 will be at the University of Leeds!
eventbrite.co.uk