51.37869, -2.36525 #Signage #Doors #BathUK #ClassicMono #Photography

Excited to share my postdoc paper from the @lyons-lab.bsky.social Our question: what controls axon diameter? It varies >100-fold between neurons, shapes signal speed & myelination, and changes in disease. Yet very little is known about what regulates it. 🧵 journals.plos.org/plosbiology/...

A high-resolution phenotypic screen identifies regulators of CNS axon diameter in zebrafish

Axon diameter is important for action potential conduction speed, but what molecular pathways influence this neuronal property? This study reports a high-resolution imaging-based chemical screening pi...

journals.plos.org

Our paper is out at @natcomms.nature.com !! A thread will follow soon. Check it out if you are interested in oligo metabolism and/or multiple sclerosis

Michael D Kornberg@mdkornberg.bsky.social · 2mo ago

www.nature.com/articles/s41...

If you're into #septin #cytoskeleton or #autoantibodies in #neurological disease, check out this paper led by Friederike Arlt. It reports anti-septin antibodies, primarily binding to PNS #myelin, in severe #autoimmune syndrome. Happy to have contributed a tiny bit. academic.oup.com/brain/advanc...

Septin multimer autoantibodies in severe motor neuropathy mimicking lower motor neuron disease

Arlt et al. describe a novel autoimmune neuropathy (‘incisuropathy’) in three patients initially thought to have an ALS variant. All had antibodies targeti

academic.oup.com

Myelin basic protein is an RNA chaperone in microglial nuclear retro-transport https://www.biorxiv.org/content/10.64898/2026.05.14.725089v1

Without you I wouldn't be here. We study #myelin; I look forward to the years ahead!

Hauke Werner@myelincentric.bsky.social · 4mo ago

I'd like to take this opportunity – being a group leader at @mpi-nat.bsky.social since this month – to thank the anonymous reviewers, the institute’s management, my fantastic team past and present, and the many wonderful colleagues with whom I've had and continue to have the privilege of working.

I'd like to take this opportunity – being a group leader at @mpi-nat.bsky.social since this month – to thank the anonymous reviewers, the institute’s management, my fantastic team past and present, and the many wonderful colleagues with whom I've had and continue to have the privilege of working.

New preprint out! In this study, we introduce NanoFLex, a strategy that combines #HaloTag variants with #nanobodies -based immunolabeling to enable rapid, OneStep-IF #lifetime #multiplexing. Possible due to SmartSecondaries fused to #HaloTag from @nanotag.bsky.social: www.biorxiv.org/content/10.6...

Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social Huge team effort, with immense contributions by friends from nearby and around the globe. www.science.org/doi/10.1126/...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel

Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

science.org

If you're interested in the factors that enable the regular structure of CNS #myelin sheaths by #oligodendrocytes, check this out. Featuring a #CDC42 - effector proteins - #septin axis. Congrats to 1st author Sophie, and a big thank you to all who contributed onlinelibrary.wiley.com/doi/10.1002/...

CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity

CDC42-effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin-dependent scaffolding of myelin. Myelin o...

onlinelibrary.wiley.com

This nice paper adds cows to the list of species using tools

Alice Auersperg@auersperga.bsky.social · 7mo ago

Our new paper (with @biotay.bsky.social) is out and on the cover story of @currentbiology.bsky.social !!!! Veronika, a Carinthian mountain cow flexibly uses a “multi-purpose tool” to scratch herself. A video and more information will follow in the comments. www.cell.com/current-biol...

Long overdue…. My congratulations!

Felipe Opazo@opazo.bsky.social · 10mo ago

Happy to tell that I got my tenured professorship at the University Medical Center in Göttingen 🇩🇪! Grateful for my students, mentors, international collaborators, the @nanotag.bsky.social team, and my family (dog included 🐾). Motivated to keep pushing science, innovation, startups, and education 🌍✨

If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed! www.biorxiv.org/content/10.1...

Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system

Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...

biorxiv.org

During the symposium @amsterdamleuko.bsky.social, I learned that lifespan and quality of life have improved because caregivers now know better how to support #leukodystrophy patients. If that’s not a cause worth spending a scientific career on, I don’t know what is. Congratulations, Marjo!

Hauke Werner@myelincentric.bsky.social · last yr.

Yesterday in Amsterdam, Marjo van der Knaap gave her retirement lecture at @vuamsterdam.bsky.social. An international group of scientists working on #leukodystrophies paid respect to her achievements, including by wearing the traditional gown. There was also a good party @amsterdamleuko.bsky.social

Leukodystrophies are rare, severe brain disorders. It’s remarkable how much the field has progressed, from identifying disease genes and understanding some of the disease mechanisms to therapy, quite a bit of that owing to Marjos work @amsterdamleuko.bsky.social

Hauke Werner@myelincentric.bsky.social · last yr.

Yesterday in Amsterdam, Marjo van der Knaap gave her retirement lecture at @vuamsterdam.bsky.social. An international group of scientists working on #leukodystrophies paid respect to her achievements, including by wearing the traditional gown. There was also a good party @amsterdamleuko.bsky.social

Yesterday in Amsterdam, Marjo van der Knaap gave her retirement lecture at @vuamsterdam.bsky.social. An international group of scientists working on #leukodystrophies paid respect to her achievements, including by wearing the traditional gown. There was also a good party @amsterdamleuko.bsky.social

It’s years since I did #leukodystrophy research, so I’m looking forward to the updates I'll get in the next 2 days symposium @amsterdamleuko.bsky.social. We‘ll also celebrate the achievements of Marjo van der Knaap, who will retire soon.

Leaving Edinburgh and the peripheral nerve society meeting with lots of impressions of how much the science in this field has advanced in the last few years, and how basic science ultimately results in therapy approaches for neuropathies. Takes years but is very much worth it.

I‘m looking forward to the next days when I’m in Edinburgh to learn about the newest research on the peripheral nervous system at pnsociety.com/2025-pns-ann...

2025 PNS Annual Meeting - pnsociety.com

pnsociety.com

If you're interested in new tools for #myelin research, here come anti-CNP #nanobodies. Congratulations to Petri Kursula, Felipe Opazo and the entire team! For structural, cell biology, and imaging data see www.biorxiv.org/content/10.1101/2024.05.25.595513v1

This interesting paper establishes zebrafish as a model to assess diameters of myelinated axons and their relevance for the speed of nerve conduction. Great work from Dave Lyons and his team in Edinburgh www.nature.com/articles/s41...

This Thursday, interesting talk in the Forum Wissen in Göttingen

Christoph Bleidorn@cblei.bsky.social · 2y ago

This thursday (Feb 22nd, 16:00 to 17:00) we will have Bryan Mathers (VisualThinkery.com) as guest in the Forum Wissen: www.forum-wissen.de/event/a-pict... The talk will be in english, as always the entry is free.

If you're looking for a current, practical overview about fluorescent imaging at very high resolution, here it is www.sciencedirect.com/science/article/pii/S0962892423002398?via%3Dihub

If you’re interested in #axon/#glia interaction and #myelin, have a look at this interesting paper. My congratulations Zoe and Aiman to this great work. I’m glad that we were able to contribute a tiny bit www.nature.com/articles/s41...