Myelin Lab
@myelinlab.bsky.social
Lab at Albany Medical College, led by Sophie Belin and Yannick Poitelon. Sciencing therapeutic strategies for myelin disorders
The final version of our article is available at www.nature.com/articles/s41...
Monocarboxylate transporter 2 regulates maintenance of myelin and axonal integrity by oligodendrocytes - Nature Communications
Metabolic determinants of white matter integrity remain elusive. Here, the authors show downregulation of MCT2 in oligodendrocytes in progressive MS, and then demonstrate its role in myelin maintenanc...
nature.com
📢 Thrilled to share our new paper @juliae.bsky.social! We show that myelin does more than insulate axons: it contains an activity-responsive transport system, TRAM, that moves organelles and helps maintain axonal health 🧠🔬 👏 Huge thanks to all our collaborators. 🔗 www.nature.com/articles/s41...
An activity-modulated transport route across myelin (TRAM) for motor-driven organelle transfer in oligodendrocytes - Nature Neuroscience
Axons require intracellular transport of cargoes between the soma and the terminus. The authors show a related logistical challenge exists at smaller scale with respect to the interaction of process-b...
nature.com
In our latest pre-print, we show that mice with the neuropathy-causing GARS1 ∆ETAQ mutation display robust pathology in subsets of peripheral nerves: www.biorxiv.org/content/10.6... Well done @beccasimkin.bsky.social and Aurélie Paulo-Ramos! @uclqsneuromuscular.bsky.social @uclqsion.bsky.social
Article “in press” @natcomms.nature.com! We show that MCT2 regulates oligo metabolism to promote maintenance of myelin and axonal integrity. @uv.es @biologiques-uv.bsky.social @achucarro.bsky.social @cipfvalencia.bsky.social @institutducerveau.bsky.social @univpoitiers.bsky.social 🧵👇
www.nature.com/articles/s41...
Glucose-dependent spatial and temporal modulation of oligodendrocyte progenitor cell proliferation via ACLY-regulated histone acetylation - Nature Neuroscience
The authors identify glucose-derived conversion of citrate to acetyl-CoA upstream of histone acetylation as modulating the regional dynamics of oligodendrocyte progenitors, with extranuclear acetyl-Co...
nature.com
Nature research paper: Focal white matter lesions drive grey matter inflammation and synapse loss go.nature.com/3Qgd47r
Focal white matter lesions drive grey matter inflammation and synapse loss - Nature
A transient grey matter microgliosis is required for remyelination, the failure of which results in a chronic neuroinflammatory state seen in neurodegenerative disorders.
go.nature.com
jobs.sciencecareers.org/job/677711/t... Come join us at Albany Medical College!
Tenure-Track Assistant or Associate Professor Position in Parkinson’s Disease - Albany, New York (US) job with Albany Medical College | 677711
We seek candidates using innovative approaches to address impactful scientific questions related to Parkinson’s disease...
jobs.sciencecareers.org
Latest offering. How myelin ensheathes axons! Born from chat with Dwight Bergles on "weird things" we saw oligodendrocytes do, like making "bridges" between sheaths. Driven forward by Cody Call, Kelly Monk, and myelin folks @edinburgh-uni.bsky.social Enjoy! www.nature.com/articles/s41...
Flexible ensheathment of axons enables myelination of complex CNS networks - Nature
The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide ...
nature.com
Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social Huge team effort, with immense contributions by friends from nearby and around the globe. www.science.org/doi/10.1126/...
Myelin sheaths in the central nervous system can withstand damage and dynamically remodel
Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...
science.org
If you're interested in the factors that enable the regular structure of CNS #myelin sheaths by #oligodendrocytes, check this out. Featuring a #CDC42 - effector proteins - #septin axis. Congrats to 1st author Sophie, and a big thank you to all who contributed onlinelibrary.wiley.com/doi/10.1002/...
CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity
CDC42-effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin-dependent scaffolding of myelin. Myelin o...
onlinelibrary.wiley.com
📢We are recruiting postdocs at the Albany Medical College to work on Schwann cells and the peripheral nervous system. 👉Apply here: albanymed.wd5.myworkdayjobs.com/en-US/Albany... Or contact us directly ;)
alert! fundamental myelin biology - led by the amazing Yevgeniya Mironova and Dwight Bergles www.science.org/doi/10.1126/...
Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors
Oligodendrocytes form myelin sheaths around axons to enable rapid signaling within neural circuits. The generation of new oligodendrocytes through differentiation of oligodendrocyte precursor cells (O...
science.org
We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth. Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry
Dereddi, Djannatian, and colleagues show that oligodendrocytes use mechanical cues to measure axon size. The stretch-activated channel TMEM63A converts membrane tension into calcium signals, which cal...
cell.com
Post Doc Fellow in the Myelin lab - job offer LinkedIn share.google/BP44iJOBeJhb...
Albany Medical Center hiring Post Doc Fellow in Albany, NY | LinkedIn
Posted 7:52:14 PM. Department/Unit:Neuroscience & Experimental TherapeuticWork Shift:Day (United States of…See this and similar jobs on LinkedIn.
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Mark your calendars! GLIA 2027 Call for Symposia opens 20 Jan–8 Apr 2026. All career stages & countries welcome. Accepted speakers get registration waived. More info: https://www.glia-meeting.eu/2027/call-for-symposia/ #Glia #Astrocytes #Microglia #Oligodendrocytes #NG2 #SchwannCells #StemCells
Pleased to share that I’ve been awarded a Catalyst Award from the @mssocietyuk.bsky.social 🥳 Many thanks to the MS Society UK for supporting our research in the @almeidalab.bsky.social and helping to advance understanding of MS!
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal! Date: Monday, Nov 17th Time: 9PM till close Location: The Smoking Gun SD, 555 Market St. All welcome, please free to spread the word!
www.nature.com/articles/s41...
Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis - Nature Medicine
Myelin damage in multiple sclerosis can be detected up to 7 years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis.
nature.com
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development. go.nature.com/4hj9NNV
Economics Nobel prize won by researchers who showed how science boosts growth
Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.
go.nature.com
NSAIDs are known to alleviate pain by reducing inflammation. A study in Nature Communications shows that selective inhibition of the prostaglandin E2 receptor in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation. #medsky 🧪
Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation - Nature Communications
Non-steroidal anti-inflammatory drugs (NSAIDs) are known to alleviate pain by reducing inflammation. To the contrary, here, the authors show that selective inhibition of the prostaglandin E2 receptor (EP2) in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation.
go.nature.com
Remyelinated fibers have a distinct lipid profile compared to intact myelin www.sciencedirect.com/science/arti...
Spatial lipidomics reveals demyelination and remyelination dynamics in the mouse brain
Myelin pathology in demyelinating diseases is accompanied by lipid remodeling that remains challenging to characterize at spatial level using traditio…
sciencedirect.com
Paper Alert!! Our collaborative work with Giger Lab at UMich is out now in #ScienceTranslationMedicine Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury | Science Translational Medicine @science.org www.science.org/doi/10.1126/...
Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury
In Sarm1-deficient mice, peripheral nervous system regeneration is delayed after injury.
science.org
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues go.nature.com/48QDdAJ
Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.
go.nature.com
"Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth" www.sciencedirect.com/science/arti...
Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth
Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in …
sciencedirect.com
🚀 Our new paper is out in Nature Communications! We uncovered a mechanistic switch to boost myelination: deleting Gtf2i in myelinating glia enhances Sox10/Mbp activity → thicker myelin, faster conduction, improved motor coordination. Open access link: www.nature.com/articles/s41...
Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements - Nature Communications
The transcriptional regulation of oligodendrocytes has an essential role in myelin formation and maintenance. Here, the authors identify the transcription factor Tfii-i as a regulator of myelin genes expression in the nervous system and show that its loss enhances myelin thickness and nerve conduction.
nature.com
Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD Thanks to Nina and all of the team!
Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function
Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...
rdcu.be
