Nutrient-sensitive histone propionylation regulates T cell fate and function https://www.biorxiv.org/content/10.64898/2026.10.01.756002v1

At the #ACSFall2026 drug candidate first disclosures session yesterday, several molecules' debuts were also their swan songs. One of them caught my eye when I looked at abstracts: an inhibitor of lipogenesis (that's synthesis of new fatty acids) aimed at treating acne. 1/

Wow- the beneficial function of the drugs Empagliflozin etc (Jardiance etc) on heart function is an off target direct effect on another enzyme www.science.org/doi/10.1126/...

SGLT2 inhibitors activate pantothenate kinase in the human heart

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce mortality in heart failure, but their pharmacological target remains unclear. In this study, we showed that SGLT2i directly activate pantothen...

science.org

Thrilled to see our work on senescence & metastasis out! We found that chemotherapy increases ovarian cancer metastasis in a paracrine manner via fructose. Dietary fructose is sufficient to increase metastatis. This work has multiple implications related to both chemo and diet.

Nature Aging@nataging.nature.com · 3mo ago

Online now!✨Cole et al identify fructose as a component of the therapy-induced SASP in senescent ovarian cancer cells and show that it reprograms cancer cells in paracrine, promoting detachment and metastasis @airdlab.bsky.social @wistar.org

Excited to announce that our research group will be joining the St. Jude Children's Research Hospital Department of Chemical Biology & Therapeutics in September. 🥼 🧬 🧪 @stjuderesearch.bsky.social

new out in Nature www.nature.com/articles/s41...

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation - Nature

The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...

nature.com

It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum.bsky.social demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats Apoorva Uboveja! www.nature.com/articles/s41...

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation - Nature

The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...

nature.com

The lab is expanding and hiring both a postdoc and staff scientist! See more on our website: airdlab.com. We study how metabolism and cell cycle states drive tumor progression, therapy response, and immune interactions. Candidates interested in mechanistic cancer biology are encouraged to apply.

Aird Lab

airdlab.com

this is a fascinating article, featuring a ton of analytical chemists arguing with one another #chemchat

Damian Carrington@dpcarrington.bsky.social · 10mo ago

‘A bombshell’: doubt cast on discoveries of #microplastics throughout human body, from brain to blood, arteries to testes Exclusive: Some scientists say many detections are most likely error, with one high-profile study called a ‘joke’ Story by me www.theguardian.com/environment/...

Anybody got an example of substrate channeling where an isotopic label in a specific product is more enriched than the tracer? I know this is theoretically possible with compartmentalized pools but I am drawing a big old blank on relevant literature?

Found out my well scored MIRA will not be funded, as I am MPI on too many grants. Not close to the direct cost cap at all, but the optics of 5 projects look bad. I understand that and really hope the grant ends up keeping someone else’s lab open. But man it hurts.

We’re hiring a #postdoc! The Dibble Lab at Harvard Medical School and Beth Israel Deaconess Medical Center in Boston studies the regulatory relationship between #signaling and #metabolic pathways. Email me at ccdibble@bidmc.harvard.edu !

Now online in Cancer Discovery: Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells - by Ilana Struys, Carolina Velázque,z @JoskeUbels, Liesbeth Lenaerts, Ruben van Boxtel, Frédéric Amant, and colleagues doi.org/10.1158/2159...

Call your legislative reps but at this point call your Fisher Sci Reps too.

Happy New Year. I’m pleased to report publication of the Ducker lab’s latest cancer metabolism paper led by graduate student Kyle Dunlap in @cp-cellreports.bsky.social www.cell.com/cell-reports.... 1/n

SLC7A5 is required for cancer cell growth under arginine-limited conditions

Metabolic adaptations are key to cancer cell survival in nutrient-limited microenvironments, but strategies for coping with arginine scarcity are poorly understood. Dunlap et al. use CRISPR screening and metabolomics to identify the plasma membrane transporter SLC7A5 as a citrulline transporter essential for cancer cell growth under arginine limitation.

cell.com

In back to back thesis committee meetings 4/8 professors had daycare age children. All of us had coughs from being sick recently. ‘Tis the season.

At the end of the day, she said, “I can’t believe they pay you just to go to meetings all day.” She thought for a minute and said, “I guess they would have to pay you.” Boy, did I feel seen. 52/n

Mass spec continues its relentless world takeover:

Real High Throughput Chemistry Through Mass Spec

science.org

New preprint alert! First authors Drs. Naveen Tangudu and Raquel Buj used both CRISPR screens and pharmacological approaches to identify novel metabolic vulnerabilities of cancers with p16 loss. Should we re-think anti-metabolites in this context? 🧪 www.biorxiv.org/content/10.1...

Having a 301 area code phone number is like a cheat code at getting professors to call you back. They all think I’m the NIH 😂🥸😂

System Collapse, the next novel in the Murderbot Diaries, is coming out November 14 from @tordotcompub.bsky.social . It's set directly after Network Effect. Cover art is by Jaime Jones.