Thrilled to see our work on senescence & metastasis out! We found that chemotherapy increases ovarian cancer metastasis in a paracrine manner via fructose. Dietary fructose is sufficient to increase metastatis. This work has multiple implications related to both chemo and diet.

Nature Aging@nataging.nature.com · 6d ago

Online now!✨Cole et al identify fructose as a component of the therapy-induced SASP in senescent ovarian cancer cells and show that it reprograms cancer cells in paracrine, promoting detachment and metastasis @airdlab.bsky.social @wistar.org

new out in Nature www.nature.com/articles/s41...

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation - Nature

The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...

nature.com

Amazing work from @airdlab.bsky.social and @mzspectrum.bsky.social Labs led by insanely talented Apporva Uboveja! Very grateful to play a small part in this impactful work.

Katherine Aird@airdlab.bsky.social · 2mo ago

It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum.bsky.social demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats Apoorva Uboveja! www.nature.com/articles/s41...

It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum.bsky.social demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats Apoorva Uboveja! www.nature.com/articles/s41...

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation - Nature

The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...

nature.com

The lab is expanding and hiring both a postdoc and staff scientist! See more on our website: airdlab.com. We study how metabolism and cell cycle states drive tumor progression, therapy response, and immune interactions. Candidates interested in mechanistic cancer biology are encouraged to apply.

Aird Lab

airdlab.com

Looking for a postdoc position and attending AACR in San Diego? I'll be there, too, and the lab is actively recruiting! Send me an email with your CV and cover letter, and I’ll follow up if there is a mutual fit. See more about our research at airdlab.com.

Join us for the 2026 NYAS Cancer Metabolism conference on March 24th at NYU Langone! The poster deadline is rapidly approaching. Speakers include @airdlab.bsky.social @bensahralab.bsky.social Javier Garcia-Bermudez, Marcus Goncalves, @naama-kanarek.bsky.social @bdmanning.bsky.social Erika Pearce,

Excited to share the Ovarian Cancer Research Syndicate line-up of speakers for the fall. Please share. We have amazing trainees presenting and the latest from leaders in the field. @powelldrescher.bsky.social @srocf.bsky.social @pennmedcso.bsky.social @penncancer.bsky.social

My lab at The Wistar Institute is recruiting on multiple levels! We are looking for a research technician and/or senior lab manager to help support all lab projects. Cell culture, molecular biology, and animal handling expertise and 3+ years of experience needed. Apply here: lnkd.in/ecvdTwkf

Big day for multiple lab members who celebrated a promotion! Congrats to Apoorva Uboveja for promotion to Staff Scientist and Aidan Cole for starting as a postdoc! I am now a full professor too 🤓 Want to learn more about our science or join the lab? Visit Airdlab.com

Aird Lab

airdlab.com

The summer has been busy! Along with the move and a PhD defense, we have updated two preprints: www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming

Cellular senescence, characterized by a stable cell cycle arrest, is a well-documented consequence of several widely used chemotherapeutics that has context-dependent roles in cancer. Although senesce...

biorxiv.org

I could not be more excited to finally announce that my lab will be moving to The Wistar Institute in Philadelphia in early September! While this is somewhat of a homecoming for me, it is a new adventure for the 6 lab members moving with me! More details to come about new roles and opportunities!

Our preprint by @raquelbuj.bsky.social was highlighted! What a cool idea to give early career scientists the opportunity to practice peer review skills! See the updated preprint: www.biorxiv.org/content/10.1....

CDKN2ALow cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance

Approximately 50% of cancers exhibit decreased CDKN2A expression ( CDKN2A Low), which is linked to immune checkpoint blockade (ICB) resistance. While CDKN2A is traditionally recognized as a tumor supp...

biorxiv.org

Nature Reviews Immunology@natrevimmunol.nature.com · last yr.

Robbie Jin & Tracy McGaha discuss a study from @raquelbuj.bsky.social @airdlab.bsky.social reporting that Cdkn2alow tumours impair macrophage phagocytosis by depriving them of zinc

Anyone else having trouble contacting Fetterman? I’ve tried both his DC and Pittsburgh office numbers, and it keeps disconnecting

Bluetorial: The rationale for the “NIH” indirect cost “plan” is based on misunderstood (unintentional or intentional) accounting and math The value of real government transparency

a cartoon of homer simpson holding a card

ALT: a cartoon of homer simpson holding a card

media.tenor.com

If you are worried about the constitutional crisis, NIH/NSF funding, diversity issues, or anything else: CONTACT YOUR REPRESENTATIVES. For those in PA: Dave McCormick: 202 224 6324 (www.mccormick.senate.gov/share-your-o...) John Fetterman: 202 224 4254 (www.fetterman.senate.gov/contact/)

BREAKING: Federal judge in Boston broadens block on Trump's NIH grant 15% overhead limit (indirect cost rates) to all recipients nationwide. Doc: www.documentcloud.org/documents/25... #TROpalooza ain't done

AAMCOrd021025

documentcloud.org

A useful tool and a great thing to do... 5calls.org/issue/nih-ns...

Save NIH and NSF Research Funding ⭑ 5 Calls

On February 7, the Trump administration moved to cut billions of dollars in funding from the National Institutes of Health (NIH) and National Science …

5calls.org

not paying indirect costs for research is like only paying the players in the Super Bowl. can't have a Super Bowl without coaches, referees, security, janitors, announcers, stadium staff, and a stadium - and you can't have research without supporting people and facilities

Cutting NIH funds hurts all Americans. Why? Three main reasons: #1: These funds support a huge industry in all states. For every $1 of NIH funding generated, there is a short-term return of ~$2.46 in economic activity. $4B in cuts will take away $10B from the economy.

So proud of Richard Fang, a senior undergrad in the lab, highlighted in this nice write-up. He is about to graduate and move on to bigger and better things as an MD/PhD student, and we will miss him! www.pitt.edu/pittwire/fea...

This Pitt senior and cancer researcher is one to keep watching

Here’s what’s next for Richard Su Fang, a Goldwater scholar who has already received interview invitations from 17 MD/PhD programs.

pitt.edu

Good Sunday. This weekly summary of papers in #cancermetabolism and #mitochondrialbiology is full of exciting discoveries. Check it here: biomed.news/bims-camemi/... @biomednews.bsky.social "The greatest obstacle to living is expectancy, which hangs upon tomorrow and loses today."-Seneca

a poster that says " never stop reading " next to a magazine

ALT: a poster that says " never stop reading " next to a magazine

media.tenor.com

This project started with a talented grad student noticing that low levels of sGC correspond to the ability of CSPC cells to evade androgen deprivation-induced senescence. Six years (2 in peer review) and one pandemic later, voila… aacrjournals.org/cancerres/ar...

Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer

Abstract. Castration-resistant prostate cancer (CRPC) is incurable and fatal, making prostate cancer the second-leading cancer-related cause of death for American men. CRPC results from therapeutic re...

aacrjournals.org

Academic Journals and News (Updated Dec 3, 2024) go.bsky.app/hCfhqn

As the community grows fast, here is an updated Metabolism Starter Pack 2 with loads of exciting scientists go.bsky.app/CH1MctZ

Want a cliffsnote version of amazing cancer discoveries from 2024? Check out the Dec issue of Cancer Discovery. It was hard to pick just 1 paper to highlight!

Itai Yanai@itaiyanai.bsky.social · 2y ago

What were the most inspiring 2024 discoveries in cancer? Cancer Discovery asked me, Katherine Aird, Aadel Chaudhuri, Jennifer Guerriero, Shiri Gur-Cohen, Benjamin Izar, Brittany Jenkins, Delphine Merino, Alejo Rodriguez-Fraticelli & Shensi Shen, & here's what we said aacrjournals.org/cancerdiscov...

Hi #TeamMassSpec! #FeMS+ has joined BlueSky! Please share and get the word out so we can build up a base here.

Do you want to read about what it’s like to be a mid- or senior career female scientist? Read this. The sexism and misogyny absolutely gets worse the higher you go.

Izzy Jayasinghe@ijayas.bsky.social · 2y ago

Reading the paper in Cell about how to close the scissor plots in gender representation at senior academic positions, I feel just a touch of pessimism. Having reached a level of seniority (middle management) I didn’t think I ever would, I read these great ideas wanting more, much more /1.

Goood Sunday, all! A very exciting curated issue of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #readingtime "Most human beings have an almost infinite capacity for taking things for granted."-Aldous Huxley

a drawing of a man with glasses and gloves with the words science mode written above him

ALT: a drawing of a man with glasses and gloves with the words science mode written above him

media.tenor.com

Dietary Restriction Enhances CD8⁺ T Cell Ketolysis to Limit Exhaustion and Boost Anti-Tumor Immunity 🧪 www.biorxiv.org/content/10.1...

Dietary Restriction Enhances CD8⁺ T Cell Ketolysis to Limit Exhaustion and Boost Anti-Tumor Immunity

Reducing calorie intake without malnutrition limits tumor progression but the underlying mechanisms are poorly understood. Here we show that dietary restriction (DR) suppresses tumor growth by enhanci...

biorxiv.org