Excited to share our work on "Pervasive interactions between exposures and polygenic risk can inform more effective clinical and behavioral interventions" @genomestake.bsky.social @natgenet.nature.com - www.nature.com/articles/s41...

Excited to share 2 important milestones in my academic journey- Our work on “Pervasive interactions between exposures & polygenic risk can inform more effective clinical & behavioral interventions,” showing PGSxC interactions & their utility, is out in #NatureGenetics @genomestake.bsky.social

In the December issue of #GENETICS, @jeremyjberg.bsky.social et al. introduce an evolutionary model of complex disease susceptibility, identifying how diseases are shaped by selection acting on other pleiotropically related traits. buff.ly/QTZPpYQ

I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵

The missing heritability question is now (mostly) answered

Not with a bang but with a whimper

theinfinitesimal.substack.com

Excited to share our latest study integrating genetics with gene expression regulation to uncover sex-specific differences in Crohn’s disease recurrence - now out in Gastroenterology. @judyibd.bsky.social @genomestake.bsky.social

IBDGC Genetics Consortium@ibdgc.bsky.social · 9mo ago

‼️"Post-operative ileum transcriptomics implicate sex-biased mechanisms in Crohn’s disease recurrence" is now available online‼️ Click the link below to access the article on ScienceDirect!🔬🧬 authors.elsevier.com/a/1m7XV3mEmn...

Longer walks linked with less mortality and cardiovascular risk compared with short bouts of physical activity @annalsofim.bsky.social www.acpjournals.org/doi/10.7326/...

Step Accumulation Patterns and Risk for Cardiovascular Events and Mortality Among Suboptimally Active Adults | Annals of Internal Medicine

Background: Although physical activity recommendations increasingly consider daily step counts, it remains unclear whether step accumulation patterns—short versus sustained longer bouts—affect associa...

acpjournals.org

Heading to Boston for the American Society of Human Genetics #ASHG25 @geneticssociety.bsky.social! Excited to present our work on how pervasive exposure-by-polygenic score interactions can inform more effective clinical and behavioral interventions. #B1070W www.medrxiv.org/content/10.1...

Dual exposure-by-polygenic score interactions highlight disparities across social groups in the proportion needed to benefit

The transferability of polygenic scores across population groups is a major concern with respect to the equitable clinical implementation of genomic medicine. Since genetic associations are identified...

medrxiv.org

Pleased to have contributed to this paper out at @nature.com today from @vw1234.bsky.social and Yira (Xinhe) Zhang showing that the common variant contribution to autism varies substantially by age of diagnosis www.nature.com/articles/s41.... Critical for understanding heterogeneity in autism.

Polygenic and developmental profiles of autism differ by age at diagnosis - Nature

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

nature.com

The age that autism is diagnosed may partly reflect underlying biological and developmental differences among individuals with autism, according to a study in Nature. go.nature.com/4gQ5gSV 🧬 🧪

Excited to share our latest manuscript on "Dual exposure-by-polygenic score interactions highlight disparities across social groups in the proportion needed to benefit" with Greg Gibson (@genomestake), https://www.medrxiv.org/content/10.1101/2024.07.29.24311065v1 [1/9]

Dual exposure-by-polygenic score interactions highlight d...

The transferability of polygenic scores across population...

medrxiv.org

Lots of interesting discussions on polygenic risk scores and their implementation @HarvardPqg - Diversity in Genetics and Genomics. #polygenicriskscores #prs #environment #diversity #biobanks #precisionmedicine

Honored to be selected as the Postdoctoral Semifinalist for 2022 Charles J. Epstein Awards for Excellence in Human Genetics Research for #ASHG22! Plus, our abstract has been selected as the Reviewer's Choice abstract 😀 #ASHG @GeneticsSociety...

Very happy and excited to share the final study of my PhD out in @MolBioEvol. All results from this study can be explored through our Rshiny: https://canalization-gibsonlab.shinyapps.io/rshiny/ https://academic.oup.com/mbe/advance-article-abstract/doi/10.1093/molbev/msac053/6547257

Reading @kph3k's wonderfully written "The Genetic Lottery", while beginning the journey to write my PhD thesis🙂 Any tips and suggestions as I embark on this journey are welcome!

Ulcerative Colitis Study Analyzes Gene Expression to Measure Risk of Progression to Surgery https://www.genomeweb.com/gene-expression-research/ulcerative-colitis-study-analyzes-gene-expression-measure-risk-progression?utm_source=addthis_shares#.YSvDkn9CI6s.twitter

Excited to share our work out in the @AJHGNews on "Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression" https://www.cell.com/ajhg/fulltext/S0002-9297(21)00296-2#secsectitle0075

Check out Greg Gibson's @genomestake interview with 11Alive about surveillance testing on GT campus. This is a great effort, congratulations ! https://www.11alive.com/video/news/health/coronavirus/georgia-tech-covid-testing/85-c6b7c338-8d22-452b-9828-13d8b22d36e8

Georgia Tech's testing program proof we can cut COVID-19 ...

As the state's COVID-19 numbers started to fall, so did t...

11alive.com

All set for the Summer Institute of Statistical Genetics at University of Washington, Seattle! Module 1: Bayesian Statistics for Genetics by Jon Wakefield and Ken Rice @UWBiostat #SISG #statgen

I'm excited for #DDW19 on May 18-21, 2019. Join me in San Diego, CA for DDW's 50th anniversary event! https://app.ingo.me/q/grita .

Digestive Disease Week® (DDW) 2019

app.ingo.me

TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits: https://www.biorxiv.org/content/biorxiv/early/2018/12/28/507525.full.pdf