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Naomi Iris van den Berg

@naomiirisvdberg.bsky.social

Postdoctoral Fellow Mathematical Oncology @crick.ac.uk. Former PhD @MRC_TU, Patil Group, Cambridge University and student @WUR, @niooknaw, @Cornell, @UCUtrecht

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Cancer Research UK Scotland Institute@cruk-si.bsky.social · 6mo ago

🆕Paper from Naomi van den Berg (@naomiirisvdberg.bsky.social) in Cancer Cell proposes the "immunometabolic gatekeeping" framework to explain how tissue metabolism conditions tumour immunity @crick.ac.uk @cruk-mi.bsky.social @uofgcancersciences.bsky.social @cp-cancercell.bsky.social

Immunometabolic gatekeeping: How tissue metabolism conditions tumor immunity

Why the link between immune infiltration and tumor control varies so strongly across tissues remains unresolved. We propose the “immunometabolic gatekeeping” framework, whereby tissue-intrinsic metabo...

cell.com

Cancer Cell@cp-cancercell.bsky.social · 7mo ago

Online Now: Immunometabolic gatekeeping: How tissue metabolism conditions tumor immunity

Immunometabolic gatekeeping: How tissue metabolism conditions tumor immunity

Why the link between immune infiltration and tumor control varies so strongly across tissues remains unresolved. We propose the “immunometabolic gatekeeping” framework, whereby tissue-intrinsic metabolic activity and waste-handling capacity shape anti-tumour immunity. In high-flux tissues, metabolic stress impairs immune surveillance, decoupling infiltration from control and allowing tumor outgrowth. This framework explains cancer paradoxes—including T cell prognostic heterogeneity, hereditary and pediatric tumor tropisms, sex-biased tumor incidence, and cancer-resistant species—and suggests metabolism-aware strategies for cancer prevention and immunotherapy.

dlvr.it

Naomi Iris van den Berg@naomiirisvdberg.bsky.social · 7mo ago

⚡Excited to share our new paper in Cancer Cell:
We propose immunometabolic gatekeeping: the idea that tissue metabolism constrains anti-tumour immunity, even pre-transformation. Why does immune infiltration not always predict good outcomes? Tissue context may be key. 🔗 www.cell.com/cancer-cell/...

Immunometabolic gatekeeping: How tissue metabolism conditions tumor immunity

Why the link between immune infiltration and tumor control varies so strongly across tissues remains unresolved. We propose the “immunometabolic gatekeeping” framework, whereby tissue-intrinsic metabo...

cell.com

Cancer Research UK Manchester Institute@cruk-mi.bsky.social · 10mo ago

New #PrePrint from @turajliclab.bsky.social and first author @naomiirisvdberg.bsky.social based @crick.ac.uk "Immunometabolic Gatekeeping: Reconciling Peto's & the T-cell Infiltration Prognostic Paradox" ➡️Metabolism may be an upstream gatekeeper of anti-tumour immunity arxiv.org/abs/2511.20883

Immunometabolic Gatekeeping: Reconciling Peto's & the T-cell Infiltration Prognostic Paradox

Classical models of cancer focus on tumour-intrinsic genetic aberrations and immune dynamics and often overlook how the metabolic environment of healthy tissues shapes tumour development and immune ef...

arxiv.org

Naomi Iris van den Berg@naomiirisvdberg.bsky.social · 2y ago

Amazing to see our review paper being circulated - thank you Prof. Solé! This paper served as the introduction to my PhD thesis and was intense but fun to write :)

Ricard Solé@ricardsole.bsky.social · 2y ago

How can we model the emergent complexity of microbial ecosystems? How do you do the maths & predict their dynamics, from the gut & the soil to the biosphere? Here's a great review paper in @natureecoevo.bsky.social. @vmaull.bsky.social @saramitri.bsky.social nature.com/articles/s41...