Next up is Robbie Burton from Newcastle University

Crystallography for the "dark proteome"? From @nudrugdiscovery.bsky.social and @chemistryncl.bsky.social : #FragLites map protein–protein interaction sites including regions with no previously known function. 🧵1/3 #DrugDiscovery #ChemBio 📖 www.sciencedirect.com/science/arti...

Just published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone! www.nature.com/articles/s41...

High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants - Nature Communications

Many protein–protein interactions depend on Short Linear Motifs (SLiMs). In this study, the authors use large-scale binding assays, deep mutational scanning, and structural analysis to map SLiMs recog...

nature.com

🧬 Engineered nanobodies binding and stabilizing cancer-mutant p16INK4a—without blocking its CDK6 interaction or cell-cycle arrest function, in press at Structure from Endicott @nucancer.bsky.social and @lauraitzhaki.bsky.social groups! 📖 www.cell.com/structure/fu...

Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a

Burbidge et al. characterize nanobodies against the tumor suppressor and CDK4/6 inhibitor p16INK4a in vitro and in cells. They show the nanobodies restore mutant p16INK4a stability. Nanobody binding t...

cell.com

this is the thing. it's not nothing. in certain contexts it is really extraordinary, I am excited to be living to see what it does. it's also not erm <checks notes> going to be god-level general intelligence in two years time (or probably ever).

Alastair Meeks@alastairmeeks.bsky.social · last yr.

Yes, but tell me again how AI gets the number of B's in blueberry wrong.

Crystallography for the "dark proteome"? From @nudrugdiscovery.bsky.social and @chemistryncl.bsky.social : #FragLites map protein–protein interaction sites including regions with no previously known function. 🧵1/3 #DrugDiscovery #ChemBio 📖 www.sciencedirect.com/science/arti...

Today was one of those Good Days in Academia where (a) an experiment gave me a result I was hoping for, which is Super Cool, and (b) an undergrad emailed asking for advice and I could give them resources and context to point them on the next step of their journey. Little important wins 🩷

Chatbots — LLMs — do not know facts and are not designed to be able to accurately answer factual questions. They are designed to find and mimic patterns of words, probabilistically. When they’re “right” it’s because correct things are often written down, so those patterns are frequent. That’s all.

I'm at #DurhamHPCDays today to present in the Computational Biosciences workshop. Always lovely to come back to Durham, and this time to see a shiny new Maths+CompSci building!

New Presidential executive order on proteins: All amino acids now to be right w̶i̶n̶g̶ handed. Leftist amino acids to be outlawed. (Also, Z-DNA is deemed to be Communist, and is prohibited.) Trans- and cis- peptide bonds to be banned. Non-binary amino acid Glycine to be banned. Proline is […]

@xtaldave.xtaldave.net.ap.brid.gy Your post to the ccp4bb is a thing of beauty.

a man in a black suit is sitting in a red chair

ALT: a man in a black suit is sitting in a red chair

media.tenor.com

Latest preprint out in the wild! This is some older work which lingered on our to-do lists; we published the crystal structure of the human IRF4 DNA-binding domain (6TD4) in 2020!

bioRxiv Biophysics@biorxiv-biophys.bsky.social · last yr.

Structural, biophysical and biological analysis and characterisation of IRF4 DNA-binding domain mutations associated with multiple myeloma https://www.biorxiv.org/content/10.1101/2025.03.12.642038v1

And thanks to the team at Newcastle for stepping up to the challenge!: @creechem.bsky.social, Rachael Pirie, @bieniekmat.bsky.social, @jthorton22.bsky.social, Ayaz Ahmad, Aaron Campbell, Kallie Friston, Natalie Roper, Roly Armstrong, Kate Harris, & @nataliejtatum.bsky.social

My daughter messaged me after her chem class the other day and asked if i could do a cartoon about Trump and Musk as isomers. Dear followers, inspired by Amelia i present to you, unconstitutional arsomers. *insert applause here* #chemsky

🌍👩‍🔬 Celebrating International Women in Science Day! Thank you to all the women in our drug discovery team, their dedication, innovation and inspiration. Together we are pushing boundaries to discover novel anticancer drugs! @nucancer.bsky.social @crhorizons.bsky.social @newcastleuni.bsky.social

A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it. www.science.org/content/blog...

What's Happening Inside the NIH and NSF

science.org

Read about our potential breakthrough in oncology - restoring wild type p53 function with ASTX295. This molecule was co-developed with Astex Pharmaceuticals, and is currently showing great phase I trial readout! #cancer #medchem #clinicaltrials www.linkedin.com/posts/cancer...

Cancer Research Horizons on LinkedIn: #onmyhorizon #cancerresearch

2024 milestones worth celebrating 🧬🌟 Bravo to the incredible researchers at the Drug Discovery Unit at Newcastle University. They&#39;ve unlocked a potential…

linkedin.com

Our research is critically dependent on funding we receive from @cancerresearchuk.org and we are also willing to do our bit towards fundraising. In 2024: Funds Raised: £6,440 (+£1,031 gift aid) Online Donations: 283 Events: Great North Run, Race for Life, Shine Walk, Leeds Marathon, bake sale, quiz

Setting up some crystallisation plates today for a new year treat/Christmas miracle. First time setting up an in situ plate for some work with @diamondlightsource.bsky.social VMXi 💎

In early phase drug discovery, biology and assays are make-or-break. I can remember very few programs I worked on which were hampered by the inability to make molecules, but plenty that were hampered by the inability to capture disease biology complexity on a chip or in an enzyme readout.

Been flying the @newcastleuni.bsky.social and @nudrugdiscovery.bsky.social flags recently, talking to @mosmedcdt.bsky.social Cohort 6 about applying computational methods appropriately + short talk at the Durham BSI bit.ly/4d7nlbB on our cyclin D3 work! bit.ly/3D6SwHF🧬🧶 #academicsky

Thrilled to share the new collaboration between @diamondlightsource.bsky.social + @crhorizons.bsky.social + @newcastleuni.bsky.social to accelerate structure-based drug development via fragment screening! More here: bit.ly/4g7Et3f 🧬🧶 #chemsky #chembio We're already hard at work on exciting targets 💪

Cancer Research Horizons and Diamond Light Source establish drug discovery partnership

Cancer Research Horizons is partnering with Diamond Light Source, the UK’s national synchrotron, to build a world-leading fragment-based drug discovery programme.

bit.ly

Per an email from Google DeepMind: Alphafold 3 is not licensed for academics to use for work that leads to a vaccine (pandemic preparations, anyone?). If structure prediction performance is comparable, people will leave AF3 for competitors with more permissive licenses

In case you missed it on the other site, we've written up some of our experiences from the CACHE2 hit finding challenge in this blog: cole-group.github.io/2024/09/10/c... Thanks to the organisers for a well-run challenge! @creechem.bsky.social @bieniekmat.bsky.social @nataliejtatum.bsky.social

Conscience@conscience-network.bsky.social · 2y ago

CACHE Challenge #2 identified seven ‘hits’ for pan-coronavirus treatment: conscience.ca/news/cache-c...

Well, there’s a story.

Congratulations to Kenneth Tan who passed his PhD viva on Tuesday 🎉 Kenneth has also recently taken up a position as a Technical Specialist in our structural biology group. Many thanks to his examiners, @nucancer.bsky.social's Luke Gaughan and @universityofleeds.bsky.social's Richard Bayliss!

#CASP16 results are in! Template-based VFold seems to be lead method for nucleic acid structure prediction! AlphaFold2 and 3 still seem to be best methods for protein monomer and complex prediction.

Pleasure to be on the judging panel for the @mosmedcdt.bsky.social Project Ideation session! An excellent showcase of ideas from all of the teams. Congratulations to our winners, who really emphasised patient need and presented a clear way forward to address it. 👏

Prof Paula Salgado@pssalgado.bsky.social · 2y ago

Congratulations @vic0210.bsky.social on winning @mosmedcdt.bsky.social project ideation talk! Great pitch, great idea, great job! Very #proudPI!

Spent today with @newcastleuni.bsky.social development team on their new leadership induction course! Lots to take away and reflect upon 💪

I am looking for 2 postdoctoral researchers to join my lab to work on the role of HIV-1 accessory proteins in the pathogenesis of HIV/AIDS and viral latency. Please contact me informally or ‘re-sky’ to anyone you think may be interested. Closing Dec 10th www.jobs.ac.uk/job/DKV639/p...

Postdoctoral Research Associate at King's College London

Discover an exciting academic career path as a Postdoctoral Research Associate at jobs.ac.uk. Don't miss out on this job opportunity - apply today!

jobs.ac.uk