New Article! A general approach for the synthesis of nanoisland catalysts
A general approach for the synthesis of nanoisland catalysts
Nature Protocols, Published online: 05 August 2026; doi:10.1038/s41596-026-01431-0Stabilization of metal single-atom or cluster catalysts is achieved by forming CeOx nanoislands on SiO2 through strong electrostatic adsorption method. Transition-metal precursors are added to form single atoms or clusters on these islands.
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New Article! Overestimations in the cyclization efficiency of small, restriction enzyme-digested DNA fragments
Overestimations in the cyclization efficiency of small, restriction enzyme-digested DNA fragments
Nature Protocols, Published online: 30 July 2026; doi:10.1038/s41596-026-01423-0Overestimations in the cyclization efficiency of small, restriction enzyme-digested DNA fragments
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New Article! Reply to: Overestimations in the cyclization efficiency of small, restriction enzyme-digested DNA fragments
Reply to: Overestimations in the cyclization efficiency of small, restriction enzyme-digested DNA fragments
Nature Protocols, Published online: 30 July 2026; doi:10.1038/s41596-026-01424-zReply to: Overestimations in the cyclization efficiency of small, restriction enzyme-digested DNA fragments
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New Article! Core2Edge: a human glioblastoma organoid–brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion
Core2Edge: a human glioblastoma organoid–brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion
Nature Protocols, Published online: 28 July 2026; doi:10.1038/s41596-026-01412-3This protocol describes Core2Edge, a human glioblastoma organoid and brain slice co-culture model that recapitulates tumor infiltration and transcriptional heterogeneity, along with a light-sheet imaging approach to capture the entire model in three dimensions.
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New Article! Three-dimensional tracking of dynamic structures in living cells using single-plane imaging with focus feedback
Three-dimensional tracking of dynamic structures in living cells using single-plane imaging with focus feedback
Nature Protocols, Published online: 28 July 2026; doi:10.1038/s41596-026-01419-wA microscopy approach for the use of focus-feedback for single-plane tracking of subcellular structures during prolonged live-cell fluorescent imaging sessions.
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When I talk to researchers about @natprot.nature.com they are most often surprised by the number of computational protocols we cover. One of the questions I get most often is what are your most popular articles? I linked the readcube links below: 🧪 🧵 #computational #methods
A collection of protocols covering a wide range of immunological-based assays and methods adapted for immunological research published @natprot.nature.com 🧪 #medsky #immunosky Take a look:
Protocols for immunological research
A collection of protocols covering a range of techniques for isolating, profiling, identifying and characterizing immune cells and biomarkers
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New Article! A programmable DNA tetrahedron platform for selective and efficient capture of cells and proteins
A programmable DNA tetrahedron platform for selective and efficient capture of cells and proteins
Nature Protocols, Published online: 27 July 2026; doi:10.1038/s41596-026-01410-5This Protocol Extension describes a programmable tetrahedral DNA nanostructure (TDN) platform for selective cell and protein capture, using aptamer-functionalized TDN for cell capture and peptide-functionalized TDN–hydrogel for protein sequestration.
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New Article! Comprehensive quantitative analysis of polyolefin hydrogenolysis toward plastic waste management
Comprehensive quantitative analysis of polyolefin hydrogenolysis toward plastic waste management
Nature Protocols, Published online: 24 July 2026; doi:10.1038/s41596-026-01385-3Polymer deconstruction, via catalytic hydrogenolysis, is an important approach for plastic recycling and upcycling. This workflow describes sequential quantitative analysis using multiple techniques to account for all of the reactants and products.
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New Article! Tutorial: guidance on the use of large language models for medical research
Tutorial: guidance on the use of large language models for medical research
Nature Protocols, Published online: 24 July 2026; doi:10.1038/s41596-026-01408-zAn entry-level guide for understanding how to choose large language models for medical research applications, customize the prompts and fine-tune the models’ performance.
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New Article! Formulation and activation of lipid-shelled nanobubble ultrasound contrast agents
Formulation and activation of lipid-shelled nanobubble ultrasound contrast agents
Nature Protocols, Published online: 23 July 2026; doi:10.1038/s41596-026-01411-4A protocol covering the synthesis of lipid-shelled nanobubbles, which enable an increase in sensitivity of contrast-enhanced ultrasound imaging and expand the possible applications in the clinical space.
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New Article! Identifying lipid–protein interactomes with functional lipid probes
Identifying lipid–protein interactomes with functional lipid probes
Nature Protocols, Published online: 22 July 2026; doi:10.1038/s41596-026-01405-2Cellular lipids are known to have specific protein interactions. This protocol describes how to study the lipid–protein interactome using multifunctional lipid probes capable of photo-cross-linking and click chemistry by in-gel fluorescence or mass spectrometry.
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New Article! Large-scale genome structure interrogation via recombinase-mediated rearrangements of multiplexed prime edits in repetitive elements
Large-scale genome structure interrogation via recombinase-mediated rearrangements of multiplexed prime edits in repetitive elements
Nature Protocols, Published online: 21 July 2026; doi:10.1038/s41596-026-01409-yThis large-scale genome structure interrogation approach uses prime editing to insert recombinase recognition sites into repetitive genomic regions. It enables thousands of precise genomic edits to be installed per cell with systematic investigation of their effects.
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New Article! Tutorial: biomembranes in hybrid living bioelectronics
Tutorial: biomembranes in hybrid living bioelectronics
Nature Protocols, Published online: 15 July 2026; doi:10.1038/s41596-026-01382-6This is a Tutorial Review on advances in bioelectronic interfaces covering research in material science for biomimetic interfaces and in synthetic biology for the reconstitution of complex biological functions.
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New Article! Preparation of solid-state emissive carbon quantum dots and their integration into electroluminescent light-emitting diodes
Preparation of solid-state emissive carbon quantum dots and their integration into electroluminescent light-emitting diodes
Nature Protocols, Published online: 15 July 2026; doi:10.1038/s41596-026-01400-7The use of carbon quantum dots (CQDs) in LED technologies is limited owing to aggregation-induced quenching in the solid state. Here, solid-state emissive CQDs with architectures that mitigate this quenching are synthesized, purified and characterized.
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New Article! Synthesis of single-crystal monolayer graphene on Cu/Ni(111) alloy foil
Synthesis of single-crystal monolayer graphene on Cu/Ni(111) alloy foil
Nature Protocols, Published online: 14 July 2026; doi:10.1038/s41596-026-01403-4This protocol outlines the fabrication of large-area single-crystal Cu foils, preparation of single-crystal Cu/Ni alloy foils, chemical vapor deposition growth of monolayer graphene and electrochemical transfer of graphene.
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New Article! Mapping 3D genome organization at nucleosome-scale with Micro-C and Region Capture Micro-C (RCMC)
Mapping 3D genome organization at nucleosome-scale with Micro-C and Region Capture Micro-C (RCMC)
Nature Protocols, Published online: 13 July 2026; doi:10.1038/s41596-026-01393-3This protocol for Micro-C achieves nucleosome-scale resolution of 3D genome organization and includes a further modification, Region Capture Micro-C (RCMC), that can provide even greater depth and the identification of even more finely resolved interactions.
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New Article! Tutorial: a beginner’s guide to fast neutron detection with an EJ-309 detector
Tutorial: a beginner’s guide to fast neutron detection with an EJ-309 detector
Nature Protocols, Published online: 13 July 2026; doi:10.1038/s41596-026-01372-8A Tutorial to make accessible the measurement of neutron yield and energy to researchers, enabling the pursuit of fusion reactor prototypes and their development.
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Springer Nature has published a series of blog posts on open science, including an interview with Steve Henikoff by Chief Ed, Mel Clyne: www.springernature.com/gp/researche...
Springer Nature@springernature.com · 3w agoWhat does open science look like in practice? We asked researchers to reflect on their experiences with open data, code, and protocols. Explore the full case studies to learn more: spklr.io/63324EPGYi #OpenScience #AcademicSky
What does open science look like in practice? We asked researchers to reflect on their experiences with open data, code, and protocols. Explore the full case studies to learn more: spklr.io/63324EPGYi #OpenScience #AcademicSky
New Article! Tutorial: strategies for targeting organelles using nanoparticles
Tutorial: strategies for targeting organelles using nanoparticles
Nature Protocols, Published online: 08 July 2026; doi:10.1038/s41596-026-01401-6In this Tutorial, the authors describe strategies for designing nanoparticles that target key organelles, including mitochondria, lysosomes, the nucleus, the endoplasmic reticulum and the Golgi apparatus.
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New Article! CODAvision: best practices and a user-friendly interface for rapid, customizable segmentation of medical images
CODAvision: best practices and a user-friendly interface for rapid, customizable segmentation of medical images
Nature Protocols, Published online: 07 July 2026; doi:10.1038/s41596-026-01404-3The semantic segmentation of microanatomical structures can be customized for the analysis of a diverse range of biomedical image modalities, including histology, magnetic resonance imaging and computed tomography.
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New Article! A scalable high-throughput serolomics platform for profiling serum antibody responses in large-scale population-based cohorts
A scalable high-throughput serolomics platform for profiling serum antibody responses in large-scale population-based cohorts
Nature Protocols, Published online: 06 July 2026; doi:10.1038/s41596-026-01391-5In this Protocol, the authors describe their automated multiplex serology workflow for large-scale population-based cohorts, an automated assay platform that robustly quantifies antibodies against up to 100 antigens in a single reaction.
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Communications Chemistry (@commschem.nature.com) has a great page celebrating outstanding referees www.nature.com/commschem/re...
Outstanding referees | Communications Chemistry
Outstanding referees
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New Article! iMUT-seq mapping of DSB-induced mutations with high sensitivity at single-nucleotide resolution
iMUT-seq mapping of DSB-induced mutations with high sensitivity at single-nucleotide resolution
Nature Protocols, Published online: 03 July 2026; doi:10.1038/s41596-026-01394-2iMUT-seq uses targeted deep sequencing to detect rare DNA double‑strand break-induced mutations, enabling insights into mutagenic outcomes and DNA repair mechanisms.
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New Article! An assay to quantify sexual commitment and stage conversion in the human malaria parasite Plasmodium falciparum
An assay to quantify sexual commitment and stage conversion in the human malaria parasite Plasmodium falciparum
Nature Protocols, Published online: 02 July 2026; doi:10.1038/s41596-026-01378-2This Protocol Update uses new transgenic reporter parasite lines and synchronized gametocyte production by shifting cultures to a defined medium. Tubulin Tracker Deep Red in combination with the reporter line enables the quantification of both sexual commitment and conversion in the same experiment.
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Tired of "methods sections" lacking detail? Check out our new preprint: "Ten simple rules for writing a reusable step-by-step protocol" 📢 This is not only for lab work. Detailed protocols are essential for reproducibility across ALL research fields 🔗 osf.io/preprints/me...
New Article! High-throughput measurements of protein domain functions using magnetic separation
High-throughput measurements of protein domain functions using magnetic separation
Nature Protocols, Published online: 30 June 2026; doi:10.1038/s41596-026-01397-zThis Protocol presents a scalable magnetic separation-based method for screening large protein domain libraries in mammalian cells, providing a simple and quantitative alternative to fluorescence-activated cell sorting for functional protein discovery.
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New Article! Inducing physiological polarity and performing gene editing using CRISPR–Cas9 in human trophoblast organoids
Inducing physiological polarity and performing gene editing using CRISPR–Cas9 in human trophoblast organoids
Nature Protocols, Published online: 29 June 2026; doi:10.1038/s41596-026-01402-5This is a protocol to reverse human trophoblast organoid polarity, producing organoids that recapitulate the outward-facing syncytiotrophoblast orientation of human chorionic villi. An additional protocol for gene editing in trophoblast organoids is also described.
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New Article! Photocatalytic low-temperature defluorination of PTFE
Photocatalytic low-temperature defluorination of PTFE
Nature Protocols, Published online: 25 June 2026; doi:10.1038/s41596-026-01390-6Polytetrafluoroethylenes (PTFEs) are chemically inert polymers with applications across various industries. This protocol describes a sustainable, visible-light-driven method for the efficient decomposition of these polymers.
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