Linda Koch
@linkonrg.bsky.social
Chief Editor @ Nature Reviews Genetics (@natrevgenet.nature.com) Half 🇩🇪, half 🇫🇷, raised in 🇵🇹, now in 🇬🇧. Opinions my own.
Thank you, @tatsuyanobori.bsky.social, for this wonderful Journal Club, which was a joy to read and edit, and for being cool with a playful image! Free to read here: rdcu.be/ft39p
New online! Stomata — guarding the gates against bacterial invasion
I talked about these papers #smbe2026. If you are interested in doing research (PhD or Postdoc) on this topic, get in touch! (if were there, sorry for the abrupt end; somehow timing got off) pubmed.ncbi.nlm.nih.gov/41763210/ pubmed.ncbi.nlm.nih.gov/39146405/ pubmed.ncbi.nlm.nih.gov/41699381/
Really enjoyed @christianlandry.bsky.social talk on Evolutionary biochemistry of gene duplication at #smbe2026 (yes he’s my husband but the second part of the talk was new results I hadn’t seen!)
🌈 At a time when progress can't be taken for granted, I 'm especially proud to share this @natcellbio.nature.com Q&A piece. I had the pleasure to discuss with @gunawanlab.bsky.social about his inspiring journey as an LGBTQIA+ immigrant. #PrideInSTEM 👉 rdcu.be/fnXQ6 www.nature.com/articles/s41...
A scientist can come from anywhere - Nature Cell Biology
This June, we celebrate Pride by discussing with Felix Gunawan, assistant professor at the University of Toronto and co-affiliate group leader at the University of Münster, about his personal and acad...
nature.com
Love Drosophila genetics — this journal club was a great way to share that enthusiasm and pay tribute to the pioneers of transposons regulation 🪰 How classical genetics uncovered key determinants of TE silencing #transposon @igred.fr @igred.fr 👇👇
New online! How classical genetics uncovered key determinants of TE silencing
I will be attending the Keystone symposium on Nucleic Acid Therapeutics and Targeted Delivery. If you’re attending and would like to chat about @natrevgenet.nature.com, editorial careers or review ideas, please reach out — or just say hi if you spot me! keysym.us/KSNATherapy26 #KSNATherapy26
Review: AI to advance CRISPR-based genome editing technologies www.nature.com/articles/s41... (read free: rdcu.be/eQKtm)
I highly recommend this fantastic review by Jennifer A. Korchak, S. Stephen Yi, @nlkproteomics.bsky.social, Nidhi Sahni and Gloria M. Sheynkman!
Proteoform medicine: characterizing and targeting protein forms in human disease go.nature.com/45P6t8z #Review by Jennifer A. Korchak, S. Stephen Yi, Neil L. Kelleher (@nlkproteomics.bsky.social), Nidhi Sahni & Gloria M. Sheynkman #proteomics
And it's a whopper of an issue!
📢 Our January issue is live and it's a special one🦠🧫! Featuring a range of article types, including Reviews, Comments and Journal Club articles, this Focus issue explores the insights gained from the application of microbial genomics within ecological and evolutionary contexts go.nature.com/3MNmsgR
Walking around the office looking for a print copy yesterday... "Oh yeah, I saw your Stranger Things cover over there..." 😁
Our December 2025 issue is now live: go.nature.com/3Lx0PB0 Topics include: the evolution of transcriptional regulatory mechanisms in animals; cell-type deconvolution methods for spatial transcriptomics; fine-mapping of candidate causal variants; and genomics of psychiatric disorders
Preprint site arXiv is banning computer-science reviews: here’s why www.nature.com/articles/d41...
Preprint site arXiv is banning computer-science reviews: here’s why
The repository is taking steps to tackle a surge in low quality, AI-generated content.
nature.com
The findings of a study in Nature shed light on germline selection dynamics and highlight a broader increased disease risk for children born to fathers of advanced age than previously appreciated. go.nature.com/4h5BglX 🧬 🧪
A reminder that you can follow all of our journals with one click by using our starter pack!
This was a really nice review to work on: A genomic view of Earth’s biomes go.nature.com/3VTLImU by Gitta Szabó, Emiley A. Eloe-Fadrosh, Jennifer Pett-Ridge & Tanja Woyke
A genomic view of Earth’s biomes - Nature Reviews Genetics
Genome-wide approaches have uncovered the vast microbial and viral diversity across ecosystems. This Review explores advances in metagenomics, single-cell sequencing and functional profiling to elucid...
go.nature.com
🎉 25 years of NRG! Feels a bit bonkers to think I’ve been at the helm for almost 12 years 🤯 Where did the time go???
Happy 25th anniversary to us! We're celebrating the journal's birthday with a bumper issue: go.nature.com/3VSbPdW Read more in our editorial "Making sense of the regulatory genome": go.nature.com/3IbWP7F And don't miss our new collection on "Long-read sequencing": go.nature.com/41Yy1Xs
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
Very happy to have contributed to this review on "non-CG" #methylation in animals now out in @natgenet.nature.com. Working again with @obog.bsky.social and Tirsa is always a pleasure. We think this not so well studied form of methylation should be more widely considered, please read: rdcu.be/eFAEk
Non-CG DNA methylation in animal genomes
Nature Genetics - This Review discusses noncanonical DNA methylation (mCH) in animal genomes and highlights the remaining need to clarify whether mCH represents a conserved regulatory layer or a...
rdcu.be
Review: Transcriptomics in the era of long-read sequencing www.nature.com/articles/s41... (read free: rdcu.be/efBjP) 🧬🖥️🧪
There is a lack of general terminology for translated regions that does not depend on the properties of their products or their sequence. Spearheaded by Pavel (Pasha) Baranov, this primer provides a unifying nomenclature for translation units: *Translon* www.nature.com/articles/s41...
Translon: a single term for translated regions - Nature Methods
Nature Methods - Translon: a single term for translated regions
nature.com
A Review in Nature Reviews Genetics discusses how genomic advances have enhanced our understanding of schizophrenia, bipolar disorder and major depressive disorder, which could address limitations in diagnostic frameworks and future treatment strategies. go.nature.com/44bKTuy 🧬 🧪
Autophagy genes in biology and disease go.nature.com/4lnHiiT #Review by Hayashi Yamamoto, Sidi Zhang & Noboru Mizushima
Autophagy genes in biology and disease - Nature Reviews Genetics
Macroautophagy and microautophagy involve characteristic membrane dynamics regulated by autophagy-related proteins to degrade cytoplasmic material in lysosomes. In this Review, the authors summarize r...
go.nature.com
Methods and applications for single-cell and spatial multi-omics go.nature.com/3GkzmzZ #Review by Katy Vandereyken, Alejandro Sifrim, @bernthie.bsky.social & Thierry Voet Free to read here: rdcu.be/c6JjL
Methods and applications for single-cell and spatial multi-omics
Nature Reviews Genetics - In this Review, the authors discuss the latest advances in profiling multiple molecular modalities from single cells, including genomic, transcriptomic, epigenomic and...
rdcu.be
Targeted genome-modification tools and their advanced applications in crop breeding go.nature.com/3T8J8bs #Review by Boshu Li, Chao Sun, Jiayang Li & Caixia Gao Free to read here: rdcu.be/dFHti
Targeted genome-modification tools and their advanced applications in crop breeding
Nature Reviews Genetics - Targeted genome modification using CRISPR–Cas genome editing, base editing or prime editing is driving base research in plants and precise molecular breeding. The...
rdcu.be
If you enjoyed our RNA splicing collection, this @natrevdrugdiscov.nature.com Review may be of interest: Protein isoform-centric therapeutics: expanding targets and increasing specificity go.nature.com/44HDClo
Protein isoform-centric therapeutics: expanding targets and increasing specificity - Nature Reviews Drug Discovery
Multiple protein isoforms arise from most genes by alternative RNA splicing and other mechanisms, but these isoforms are often neglected in drug discovery. This Review discusses the modes of action of...
go.nature.com
Our June issue is live and includes an editorial on RNA splicing (go.nature.com/3SdWVgk) that acts as a foreword for a new joint collection by @natrevgenet.nature.com and @natrevmcb.nature.com on this topic (go.nature.com/3H0vEvp)
Evolution of splicing model architectures go.nature.com/4eweliE Figure from our recent Review: From computational models of the splicing code to regulatory mechanisms and therapeutic implications (free to read here: rdcu.be/dVNV4)
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