Looking forward!

FragileNucleosome@fnucleosome.bsky.social · 4d ago

🧬🧬🧬 Join us on Wednesday next week for the next #FNucleosome seminar. We've got two exciting transcription/chromatin talks from @nellykanata.bsky.social and Yukun Wang! You can register here to receive the zoom invite: us06web.zoom.us/webinar/regi...

I am very excited to share the work of my PhD with @eddaschulz.bsky.social, now on BioRxiv! 🎉 🧵⬇️ (1/9) How does the transcription↔️chromatin crosstalk ensure monoallelic expression?

bioRxivpreprint@biorxivpreprint.bsky.social · 3mo ago

Transcription-dependent heterochromatin at the Xist promoter shapes the random choice of the inactive X chromosome https://www.biorxiv.org/content/10.64898/2026.07.22.737064v1

🧵 Happy to share that the final version of our study is finally out in @natcomms.nature.com today: www.nature.com/articles/s41... What started as an unexpected observation—that SETDB1 depletion accelerates X chromosome silencing—led us to uncover a role for SETDB1 in regulating Xist transcription.

SETDB1 and HUSH modulate Xist RNA levels during establishment of X chromosome inactivation - Nature Communications

Regulation of X chromosome inactivation in mammals requires precise control of the levels of the non-coding RNA Xist. Almeida et al. describe an autoregulatory mechanism in which nascent Xist transcri...

nature.com

Super interesting paper we discussed at the Journal Club today about the secret behind the bowhead whale living over 200 years! 🐋

Evidence for improved DNA repair in the long-lived bowhead whale

Nature - Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.

rdcu.be

I started Awesome Life Science Resources: a curated list of resources on work culture, career, and communication for life scientists. Built for PhD students, postdocs, and PIs. Check it out: github.com/jjfroehlich/...

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation. 👉 We discover how sex and development signals are decoded at a single gene locus. www.nature.com/articles/s41... 👇 Bluetorial

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology

Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

nature.com

They couldn’t silence their stories. So they just killed them. Israel never comes back from this.

Bye forever, WeTransfer.

I'm really happy to see the work from my Master's thesis published! 🎉 Shoutout to everyone who helped make this happen — especially @albaperez.bsky.social for the amazing mentorship and Alfred for the opportunity to work on this cool project! Check it out 👀

CortesMalaria Lab@cortesmalaria.bsky.social · last yr.

📣Rush to read our latest paper!! journals.plos.org/plospathogen.... You'll learn why #heterochromatin is formed and maintained in specific regions of the Plasmodium falciparum genome and not others 🧵⬇️

While helping out on a cool genomics project recently, I came to realise I’d been taught a pretty big inaccuracy about the events that occur at fertilization. I suspect that almost everyone reading this has the same misapprehension, so let’s do some learning together: 1/

Terminal Genome Viewer (tgv), written in Rust github.com/zeqianli/tgv

Amazing documentary, and a strong slap in the face. If you eat fish, make sure you know where it comes from.

Greenpeace Canada@greenpeaceca.bsky.social · last yr.

We already have one industry – bottom trawling – tearing up the ocean floor & wiping out sea life. We don't need another one 🙅 ✍️SIGN to #StopDeepSeaMining before it starts: act.gp/43wURX6 🎥 OCEAN w/ David Attenborough in theatres May 24, clip via Silverback Films #ProtectTheOceans #BottomTrawling

It is sad that even basic research needs to be defended with utility. For me, basic research is in the same category as art: civilized societies can't do without it, because we all want to know who we are and what our place in the natural world is -- questions that only science can answer.

We stand up for science!

Max Planck Institute for Molecular Genetics@molgen.mpg.de · 2y ago

#StandUpForScience👩‍🔬👨‍🔬📢Scientists at the Max Planck Institute for Molecular Genetics in Berlin, including our managing director, show solidarity with our colleagues in the US who are protesting against the attacks of the current US administration. @standupforscience.bsky.social @maxplanck.de

Just your friendly reminder that there are alternatives to Mapping apps owned by big companies... One of them is called OpenStreetMap -- it is crowdsourced and the data is open and non-commercial. Via the API, there are downloadable app versions for your phone. www.openstreetmap.org/about

OpenStreetMap

OpenStreetMap is a map of the world, created by people like you and free to use under an open license.

openstreetmap.org

With International Women's Day coming up before too long, any chance someone is building a gender pay gap bot for Bluesky like the one that used to exist on that other app? 😁 www.bbc.com/news/uk-engl...