1/ Very excited to share the first publication from my lab! In this work, we developed an efficient strategy to precisely mutate mammalian histone genes in their native genomic context using CRISPR prime editing: www.nature.com/articles/s41...

Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing - Nature Genetics

This study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combinat...

nature.com

🚨Preprint Drop🚨 We are very pleased to release our study on DNA methylation dynamics at enhancers during ESC differentiation! This work was led by Marlet Morales-Franco and Priscillia Lhoumaud 🧵(1/13) www.biorxiv.org/content/10.6...

Dual profiling of DNA modifications with enhancer features during the exit of naive pluripotency

Cis-regulatory elements, such as enhancers, play an essential role in coordinating gene expression programs during cellular transitions. As such, substantial efforts have been made to characterize enh...

biorxiv.org

Exciting PhD position available in the Diepold lab @kit.edu ! We're especially interested in international students with expertise in molecular biology and ready to lead a cutting-edge research project in molecular machines and infection biology. Find out more at diepoldlab.com.

Postdoc position available now in the Smith Group lsi.exeter.ac.uk/groups/smith... to test the hypothesis that differentiation biases between human pluripotent stem cell lines may be eliminated by reversion to the naïve state. careers.exeter.ac.uk/vacancies/79...

Congratulations, Mafalda, Neil and team!

Mafalda Almeida 🇵🇹 🇪🇺 🇬🇧@bluebuleta.bsky.social · 2mo ago

🧵 Happy to share that the final version of our study is finally out in @natcomms.nature.com today: www.nature.com/articles/s41... What started as an unexpected observation—that SETDB1 depletion accelerates X chromosome silencing—led us to uncover a role for SETDB1 in regulating Xist transcription.

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Excited to share our first story led by @martinacapriati.bsky.social! How do cells control the expression of viability genes? We find that single transcription factors can drive both chromatin opening and gene activation from densely co-bound CpG island promoters, including at essential genes

Hello all, our lab is recruiting a PhD candidate to study how 3D genome folding impacts gene regulation in development. We're located at the Center for Integrative Genomics department of the University of Lausanne, Switzerland. Please email me if interested. #PhDPosition, #PhDOpportunity

Very excited to share our newest findings! A very long team effort pursued by multiple team members -to frantically reproduce everything over and over-, we show mTOR-Polycomb synergy at promoters of developmental master regulator TFs in ESCs prior to their expression. www.biorxiv.org/content/10.6...

My lab is looking for a PhD student 🔥 Starting date: flexible - end of 2026/beginning of 2027 👉 Are you interested in understanding how diet, metabolism and the environment shape cell and organismal function through chromatin and nuclear organisation? Read more 👇

Die Bundesregierung will geheimhalten, wo sie neue fossile Infrastruktur in Deutschland plant. Wir schaffen Transparenz und zeigen, wo neue Kraftwerke, Bohrungen, Pipelines und Flüssiggas-Terminals entstehen sollen – und wie ihr dagegen aktiv werden könnt: fragdenstaat.de/aktionen/cli...

Wissenschaft umfasst neben Labor und Publikationen auch Präsentationen, Mentoring und Karriereplanung. Jonathan Fröhlich stellt dafür über 200 Ressourcen frei zur Verfügung und teilt somit eine 8 Jahre gefütterte Schatzkiste: www.laborjournal.de/editorials/3... #Laborjournal #LifeSci #OpenScience

Had a cracking lab meeting this morning with our latest epigenome editing results (new tools we're trying for the 1st time). Reminded me we're organizing an awesome symposium in Paris in Nov! Here's our updated flyer (new speaker @dfachinetti.bsky.social). Please share! ctrlepiedit.sciencesconf.org

Hi all! 👋 leeboratory.bsky.social and I are recruiting a VIP³ postdoc to join our teams and decode the genetic logic of how blastoids transit to the post-implantation stage. MolBio, genetics and computational approaches. If this sounds like you (or someone you know), we’d love to hear from you! 🚀

Vienna BioCenter Scientific Training@vbcscitraining.bsky.social · 4mo ago

Why choose the Vienna BioCenter - Hear it directly from our fellows! The VIP³ call is open – 8 fully-funded, three-year postdoctoral fellowships in an interdisciplinary environment: https://training.vbc.ac.at/post-docs/vip3-post-doc-program/ #VBCPostDoc

I'm really excited to speak at this year's EMBL Transcription and Chromatin meeting in August!

EMBL Events@events.embl.org · 5mo ago

At #EMBLTranscript, experts will share breakthroughs across the full spectrum of #transcription – from cis-regulatory function and long-range regulation to 3D looping, basal transcriptional machinery, #chromatin modifications, #epigenetic inheritance, and more 🧬 Join us: s.embl.org/trm26-01-bl

I'm really excited about this meeting on epigenetic editing!

Maxim Greenberg@maxvcg.bsky.social · 5mo ago

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

I’m thrilled to share that my PhD work has been just published in Cell. After a long and bumpy ride, we uncovered the core function of nuclear speckles -splicing of GC-levelled exons- and traced the evolution of this gene architecture and condensates themselves to amniotes.

Tugce Aktas@aktast.bsky.social · 5mo ago

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.

1/ In 12 Tagen möchte die Bundesregierung ~300 Millionen an die Firma STARK zahlen, die u.a. Peter Thiel, Döpfners & der CIA gehört. Es geht nicht um irgendein Produkt, sondern um Waffen zum Schutz unseres Landes. Es droht ein zweites “Palantir”. Das sollten wir nicht zulassen!

Janosch Dahmen@janoschdahmenmdb.de · 6mo ago

Während alle Welt über Epstein entsetzt ist, möchte die Bundesregierung einer Peter Thiel-Firma 300 Millionen geben und sie zum Teil der deutschen Verteidigung machen. Dabei trafen sich Epstein & Thiel, jahrelang regelmäßig mit russischen Verbindungsleuten. Sein wir nicht naiv!

🧪 My lab has an opening for a postdoc position soon! Please share/get in touch!

📣NuQuest consortium update: Our first joint publication is out!Review on quiescence—A milestone for our initiative laying out the scientific groundwork & collaborative vision for our MSCA-DN application coordinated by @jlugiessen.bsky.social 1/n www.mdpi.com/3700996 #NuQuest #MSCA #DoctoralNetwork

Secure your in-person place at Synthetic Biology 2026! #SynBio26 Register by 9 February ⏰ Hear #SynBio research from globally leading scientists. Don’t miss our “Meet the Editors” session—your chance to get insights on the publication and peer-review process. 📎 bit.ly/43nlbBW #ALife ⚙️🧫

Congratulations, Scott and team!

Scott Berry@scottbscience.bsky.social · 7mo ago

What happens when you suddenly remove half of an essential enzyme from cells? 🤔 We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance. Our lab's new preprint 👇 bit.ly/4pyPgax

⚠️ The final work of two former PhD students Till @tschwammle.bsky.social and Verena @verenamutzel.bsky.social is out! ➡️⬅️ They dissect how memory can arise from antisense transcription using mathematical modelling 💻, genomics 🧬 and synthetic biology ⚒️! link.springer.com/article/10.1...

Antisense transcription can induce expression memory via stable promoter repression - Genome Biology

Background The capacity of cells to retain a memory of previous signals enables acquisition of unique fates and adaptation to their environment. The underlying gene expression memory can arise from mu...

link.springer.com

I'm excited to participate in the upcoming Wellcome conference on synthetic biology 🛠️🧬 with a great lineup of speakers! It's still possible to sign up, as the abstract deadline has been extended until January 5th 📄 - join us!

Wellcome Connecting Science Learning and Training@eventswcs.bsky.social · 10mo ago

Meet our speakers for #SynBio26 🌟 Field experts will provide fascinating insights on how synthetic based-biology innovations are transforming human health and planetary sustainability. Submit an abstract by 1 December 2025 - bursaries available 📎 bit.ly/43nlbBW #ALife ⚙️🧫

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

Escape from X inactivation is directly modulated by Xist noncoding RNA

Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

rdcu.be

Thanks @pasquelab.bsky.social and his team for this collaboration.

Vincent Pasque@pasquelab.bsky.social · 8mo ago

𝐍𝐞𝐰 𝐩𝐫𝐞𝐩𝐫𝐢𝐧𝐭 𝐚𝐥𝐞𝐫𝐭! 🎉 “𝐗𝐈𝐒𝐓 𝐃𝐫𝐢𝐯𝐞𝐬 𝐗-𝐂𝐡𝐫𝐨𝐦𝐨𝐬𝐨𝐦𝐞 𝐈𝐧𝐚𝐜𝐭𝐢𝐯𝐚𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐒𝐚𝐟𝐞𝐠𝐮𝐚𝐫𝐝𝐬 𝐅𝐞𝐦𝐚𝐥𝐞 𝐄𝐱𝐭𝐫𝐚𝐞𝐦𝐛𝐫𝐲𝐨𝐧𝐢𝐜 𝐂𝐞𝐥𝐥𝐬 𝐢𝐧 𝐇𝐮𝐦𝐚𝐧𝐬” 𝐢𝐬 𝐧𝐨𝐰 𝐨𝐧 𝐛𝐢𝐨𝐑𝐱𝐢𝐯! www.biorxiv.org/content/10.1...

📣 SAVE THE DATE Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social

New paper from the lab: we’re using long-read sequencing to disentangle isoform complexity at allele-specific loci 🧬💡 Here, we combine the PacBio Iso-Seq workflow with the established WhatsHap phasing approach to assign long reads to the correct allele in polymorphic F1 mouse hybrids.

🧬 Interested in dissecting dose-dependent transcriptional regulation through epigenome editing and synthetic biology for your PhD? Apply by 07.01.2026 to join the lab of @eddaschulz.bsky.social @molgen.mpg.de & #IMPRS-BAC #gradschool. 👉 www.molgen.mpg.de/5099133/schu...