I’m very happy to have contributed to this cool project, but the best part has been working together with @nellykanata.bsky.social !☀️

@nellykanata.bsky.social · 4mo ago

(4/9) We studied heterochromatin at the Xist promoter during the onset of random X-inactivation in mouse ESCs. @ingridpelaez.bsky.social developed a brilliant dual-color reporter line 🔴🟡 to sort cells by which X they inactivate. We found that H3K9me3 ends up only on the silent Xist promoter!

I am very excited to share the work of my PhD with @eddaschulz.bsky.social, now on BioRxiv! 🎉 🧵⬇️ (1/9) How does the transcription↔️chromatin crosstalk ensure monoallelic expression?

bioRxivpreprint@biorxivpreprint.bsky.social · 4mo ago

Transcription-dependent heterochromatin at the Xist promoter shapes the random choice of the inactive X chromosome https://www.biorxiv.org/content/10.64898/2026.07.22.737064v1

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...

Super interesting paper we discussed at the Journal Club today about the secret behind the bowhead whale living over 200 years! 🐋

Evidence for improved DNA repair in the long-lived bowhead whale

Nature - Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.

rdcu.be

I started Awesome Life Science Resources: a curated list of resources on work culture, career, and communication for life scientists. Built for PhD students, postdocs, and PIs. Check it out: github.com/jjfroehlich/...

🤩💪 Out now! 3D regulatory hubs in sex determination With @mamartirenom.bsky.social & Capel labs, led by @imotagom.bsky.social & @jrotwitguez.bsky.social 1️⃣ METALoci – explore #3DGenome 🧬 2️⃣ Non-coding region controlling Fgf9 🧩 3️⃣ Meis genes = new key players 🌟 👉 rdcu.be/e5sm2 1/n Bluetorial 👇

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs

Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

rdcu.be

⚠️ The final work of two former PhD students Till @tschwammle.bsky.social and Verena @verenamutzel.bsky.social is out! ➡️⬅️ They dissect how memory can arise from antisense transcription using mathematical modelling 💻, genomics 🧬 and synthetic biology ⚒️! link.springer.com/article/10.1...

Antisense transcription can induce expression memory via stable promoter repression - Genome Biology

Background The capacity of cells to retain a memory of previous signals enables acquisition of unique fates and adaptation to their environment. The underlying gene expression memory can arise from mu...

link.springer.com

🧬 Interested in dissecting dose-dependent transcriptional regulation through epigenome editing and synthetic biology for your PhD? Apply by 07.01.2026 to join the lab of @eddaschulz.bsky.social @molgen.mpg.de & #IMPRS-BAC #gradschool. 👉 www.molgen.mpg.de/5099133/schu...

Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

Thank you to Merve Büşra Duman, @ingridpelaez.bsky.social and Tommaso Stentella, who organized this year's MPIMG PhD retreat! The event provided our PhD students with a blend of scientific sessions, career opportunity insights, and workshops on scientific illustration and project management.

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation. 👉 We discover how sex and development signals are decoded at a single gene locus. www.nature.com/articles/s41... 👇 Bluetorial

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology

Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

nature.com

🚨JOB ALERT🚨 FRIENDS PLEASE SPREAD and RT We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility. See below 2 calls👇

The peppered moth is a textbook example of natural selection, its colours shifting with the soot-darkened trees of the Industrial Revolution. But the genetic secret behind its “dark” form took 150 years to uncover: a new “jumping gene” that rapidly took over the population. 🦋 tinyurl.com/4zrc4e93

The “dark” secret of industrial moths

The peppered moth has long been a textbook example of natural selection, its colours shifting with the soot-darkened trees of the Industrial Revolution. But the genetic secret behind its “dark” for…

tinyurl.com

Pre-print alert 🚨: We have developed 2D and 3D stable iPSC endothelial-differentiation models through dox inducible ETS expression. We demonstrate endothelial identity and used these models for studying malaria pathogenesis research. www.biorxiv.org/content/10.1...

I'm really happy to see the work from my Master's thesis published! 🎉 Shoutout to everyone who helped make this happen — especially @albaperez.bsky.social for the amazing mentorship and Alfred for the opportunity to work on this cool project! Check it out 👀

CortesMalaria Lab@cortesmalaria.bsky.social · last yr.

📣Rush to read our latest paper!! journals.plos.org/plospathogen.... You'll learn why #heterochromatin is formed and maintained in specific regions of the Plasmodium falciparum genome and not others 🧵⬇️

⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.

Last week we celebrated the 10th anniversary of the Schulz Lab with an amazing retreat alongside the lab's alumni! ☀️ In addition to canoeing and hiking, we also shared our career paths and current projects with each other. 🛶🌳

Congrats Elodie!!! ✨🥳🫶🏼

#StandUpForScience2025 ! 📢✊🏻

Max Planck Institute for Molecular Genetics@molgen.mpg.de · 2y ago

#StandUpForScience👩‍🔬👨‍🔬📢Scientists at the Max Planck Institute for Molecular Genetics in Berlin, including our managing director, show solidarity with our colleagues in the US who are protesting against the attacks of the current US administration. @standupforscience.bsky.social @maxplanck.de

First cake in the sun this year with the Schulz Lab! ☀️

We designed MS2 and PP7 binding coat proteins that are degraded in cells except when bound by their hairpin RNAs. You can check out our pre-print here: tinyurl.com/27p7hyt9, and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...

A throwback to last month's 'Quantitative biology to molecular mechanisms' conference – time to introduce the poster prize winners! #EMBLOmics A round of applause for: 🏅 Max Trauernicht 🏅 @ingridpelaez.bsky.social 🏅 Honorine Destain 🏅 Óscar García Blay Read on 👉🏻 s.embl.org/omx24-01-blog @embl.org

I attended the ‘Quantitative Biology to Molecular Mechanisms’ conference at EMBL Heidelberg last week and had the incredible honor of winning one of the Poster Prizes! 🏆 A big thanks to the organizers and all the amazing speakers who shared their inspiring research with us. ✨ #EMBLOmics