Nick Sanderson
@nickdsandy.bsky.social
Bioinformatician interested in infection and immunity. Direct from sample sequencing for diagnostics. MMM group, NDM, Oxford University
“Let’s make children less safe” is, on the face of it, quite a bold local election promise.
A Carterton town council election is being fought today with candidates competing with each other to oppose a School Streets scheme outside two primary schools. Conservative leader Liam Walker called it “draconian” while Reform councillor Natalie King said she was “absolutely fumming”.
Thames water just closed our account. Completely out of the blue for no reason. We can’t contact them, because we have no account with them now. Total incompetence
I have a LinkedIn, I don't really use it. Just did my usual weekly scan and it's just 99% AI booster slop now? Infographics? Slop. "How not to sound like AI"? Post clearly written by AI. Random unrelated suggestion? AI. This is not healthy.
just wanted to read a kids’ menu online and look at all this fucking shit lmao
Oxford University and JR hospital researchers have developed a genetic sequencing method to quickly work out which bacteria are causing bloodstream infections + which antibiotics they are resistant to, helping improve sepsis care and give patients the right antibiotics www.ox.ac.uk/news/2026-05...
My first foray into linear plasmids in a new-to-me bug (VRE) - they are pretty neat! 🧵1/n
Linear plasmid prevalence and linezolid resistance gene carriage in vancomycin-resistant Enterococcus in Canada from 2009-2024 https://www.medrxiv.org/content/10.64898/2026.05.08.26352429v1
Long-read sequencing of Mycobacterial tuberculosis is comparable to short-read sequencing for antimicrobial resistance prediction and epidemiological studies. https://www.biorxiv.org/content/10.64898/2026.04.08.717216v1
Project Hail Mary is a great film and lived up to the book, that I loved. But it should come with a trigger warning for the unbalanced centrifuge scene
Deacon can now run in the browser using WebAssembly. Sequence data never leaves your machine. It currently supports FASTA/Q filtering using indexes up to 1GB in size. Demo: bede.im/deacon
New preprint from us @modmedmicro.bsky.social where we validate the diagnostic accuracy of a metagenomic nanopore sequencing method for respiratory RNA viruses. www.medrxiv.org/content/10.6...
Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study
Background Clinical metagenomics (CMg) offers high-throughput respiratory pathogen detection with a wider range than targeted, probe-dependent diagnostics. Sequencing cost and the challenges of high h...
medrxiv.org
New preprint from us @modmedmicro.bsky.social where we validate the diagnostic accuracy of a metagenomic nanopore sequencing method for respiratory RNA viruses. www.medrxiv.org/content/10.6...
Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study
Background Clinical metagenomics (CMg) offers high-throughput respiratory pathogen detection with a wider range than targeted, probe-dependent diagnostics. Sequencing cost and the challenges of high h...
medrxiv.org
1/4 Thrilled to get this metagenomic diagnostic study over the line. We have an in house method that targets RNA viruses in respiratory samples, and evaluated this against 344 prospective samples tested by multiplex PCR. www.medrxiv.org/content/10.6...
Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study
Background Clinical metagenomics (CMg) offers high-throughput respiratory pathogen detection with a wider range than targeted, probe-dependent diagnostics. Sequencing cost and the challenges of high h...
medrxiv.org
Are you a post-doctoral microbiologist interested in characterising bacterial resistance evolution and want to apply your knowledge and expertise to developing new therapeutics for Klebsiella (and other Enterobacterales) infections? Then we need you! Apply now bit.ly/3MX39Ce close date March 13th 👀
Job Details
my.corehr.com
International Day of Women and Girls in Science 👩🔬 Proud to work alongside the scientists in our #microbiology lab whose work in antimicrobial resistance, public health and diagnostics has real-world impact! #WomenInScience #AMR #PublicHealth @medsci.ox.ac.uk @ox.ac.uk @oxfordbrc.bsky.social
A long time ago in a galaxy far away, there was a SARS-CoV-2 pandemic. Our paper, led by @martibartfast.bsky.social a) correcting errors in 4.5 million genomes & their phylogeny b) improving representation of the Global South in public data www.nature.com/articles/s41... (thread 1/n)
Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny - Nature Methods
This Resource paper presents a global SARS-CoV-2 phylogenetic tree of 4,471,579 high-quality genomes consistently constructed by Viridian, an efficient amplicon-aware assembler.
nature.com
Ziplign published in JOSS. Tool to easily interactively compare two bacteria genomes. Inspired by ACT, but easier to install and use. Drag and drop files, or download using accessions. It runs blast for you. No terminal needed. github.com/martinghunt/...
Just published in JOSS: 'Ziplign: a simple-to-use interactive tool to compare bacterial genomes' https://doi.org/10.21105/joss.09004
Clarion news: We’re leaving Twitter (’X’). We can’t condone the objectionable content it now promotes, which goes against everything we believe and the Clarion tradition. Our live posting is now here on Bluesky, with all this plus much more in our email newsletter twice a week.
Good luck to the journal editor trying to get me to review a paper today with a 14 day turnaround 🙃
It's 2025, why are all reference managers still crap.
New preprint! Deacon is a versatile tool for filtering FASTA/FASTQ files and streams at hundreds of megabases per second using minimizers, built with rapid metagenomic host depletion in mind, but equally useful for search. github.com/bede/deacon
Deacon: fast sequence filtering and contaminant depletion https://www.biorxiv.org/content/10.1101/2025.06.09.658732v1
Deacon: fast sequence filtering and contaminant depletion https://www.biorxiv.org/content/10.1101/2025.06.09.658732v1
Terminal Genome Viewer (tgv), written in Rust github.com/zeqianli/tgv
A new preprint from us. Nanopore adaptive sampling for bacterial identification from periprosthetic joint replacement tissue. Where high host contamination is still a big issue. We find modest improvements in bacterial yield. But not enough to improve diagnostics www.medrxiv.org/content/10.1...
Nanopore adaptive sampling for bacterial identification from periprosthetic joint replacement tissue
Metagenomic approaches to diagnosis of prosthetic joint infections promise more accurate and more rapid diagnosis. However, the high host DNA to bacterial DNA ratio is a challenge. Nanopore adaptive s...
medrxiv.org
Come and work with us! We are looking for a Medical Statistican. Closing date: 4 Feb 2025 bit.ly/3E5JtaI
Job Details
bit.ly