Tessera
Folgen

Noel Research Group

@noelgroupuva.bsky.social

Our research focuses on the synergy between #Synthetic #OrganicChemistry and #Technology. #ChemSky

49 Posts1015 Follower390 Folgt
@pkatlas.bsky.social · 10mo ago

My student forgot to add a stir bar to a biphasic reaction in a sealed container. I said let's go ahead and try after reading that paper. Lo and behold, we got almost no conversion. The reaction worked fine when resubjected with a stir bar. At least for biphasic reactions, it's still crucial to stir

Noel Research Group@noelgroupuva.bsky.social · 10mo ago

Our ChemRxiv article keeps moving; thanks #ChemistryWorld for covering the debate. Critics say it’s “too early” for conclusions, yet mixing principles are grounded in 100+ years of science. Read and make up your own mind. Here is our @chemrxiv.org article: chemrxiv.org/engage/chemr...

Chemistry World@chemistryworld.com · 10mo ago

Earlier this year, a paper came out that suggested for many organic reactions stirring has little effect on reactions rates. Now, a group has released a preprint arguing that stirring remains critical for reproducibility, selectivity and scalability.

Noel Research Group@noelgroupuva.bsky.social · 10mo ago

Our ChemRxiv article keeps moving; thanks #ChemistryWorld for covering the debate. Critics say it’s “too early” for conclusions, yet mixing principles are grounded in 100+ years of science. Read and make up your own mind. Here is our @chemrxiv.org article: chemrxiv.org/engage/chemr...

Chemistry World@chemistryworld.com · 10mo ago

Earlier this year, a paper came out that suggested for many organic reactions stirring has little effect on reactions rates. Now, a group has released a preprint arguing that stirring remains critical for reproducibility, selectivity and scalability.

Chemistry World@chemistryworld.com · 10mo ago

Earlier this year, a paper came out that suggested for many organic reactions stirring has little effect on reactions rates. Now, a group has released a preprint arguing that stirring remains critical for reproducibility, selectivity and scalability.

All stirred up: chemical engineers refute claims that ‘stirring doesn’t matter’

Failing to mix reactions in heterogeneous or industrial systems could cause numerous issues and might even be dangerous, preprint claims

chemistryworld.com

Noel Research Group@noelgroupuva.bsky.social · last yr.

Our group’s mission: exploring the synergy between organic chemistry & technology. In our new @jacs.acspublications.org Perspective, we highlight 6 technologies reshaping synthetic organic chemistry: ⚙️ Flow 💡 Photo ⚡ Electro 🌱 Bio 🌀 Mechano 🤖 Automation 👉 doi.org/10.1021/jacs...

Tech-Enhanced Synthesis: Exploring the Synergy between Organic Chemistry and Technology

Recent years have witnessed growing interest in integrating enabling technologies into synthetic organic chemistry to address long-standing challenges in reproducibility, sustainability, and scalability. This perspective showcases how modern tools, ranging from continuous-flow reactors and electrochemical cells to photochemical technologies, biocatalysis, mechanochemistry, and self-driving laboratories, are reshaping the way chemists design, perform, and optimize reactions. Through selected case studies, we highlight how these technologies not only solve specific reactivity and process issues but also open new avenues for reactivity discovery and chemical innovation. Rather than viewing technology as a complication, we advocate for its adoption as a natural extension of synthetic creativity, capable of enhancing safety, reducing waste, and expanding accessible chemical space. Our aim is to inspire broader implementation and interdisciplinary training to equip the next generation of chemists with the tools to rethink how synthesis is performed in the 21st century.

doi.org

Noel Research Group@noelgroupuva.bsky.social · last yr.

Our group’s mission: exploring the synergy between organic chemistry & technology. In our new @jacs.acspublications.org Perspective, we highlight 6 technologies reshaping synthetic organic chemistry: ⚙️ Flow 💡 Photo ⚡ Electro 🌱 Bio 🌀 Mechano 🤖 Automation 👉 doi.org/10.1021/jacs...

Tech-Enhanced Synthesis: Exploring the Synergy between Organic Chemistry and Technology

Recent years have witnessed growing interest in integrating enabling technologies into synthetic organic chemistry to address long-standing challenges in reproducibility, sustainability, and scalability. This perspective showcases how modern tools, ranging from continuous-flow reactors and electrochemical cells to photochemical technologies, biocatalysis, mechanochemistry, and self-driving laboratories, are reshaping the way chemists design, perform, and optimize reactions. Through selected case studies, we highlight how these technologies not only solve specific reactivity and process issues but also open new avenues for reactivity discovery and chemical innovation. Rather than viewing technology as a complication, we advocate for its adoption as a natural extension of synthetic creativity, capable of enhancing safety, reducing waste, and expanding accessible chemical space. Our aim is to inspire broader implementation and interdisciplinary training to equip the next generation of chemists with the tools to rethink how synthesis is performed in the 21st century.

doi.org

Robert Pollice@robpollice.mstdn.science.ap.brid.gy · last yr.

#RobSelects preprint of the week #ChemRxiv: A frugal flow-based self-driving laboratory platform for optimization of diverse organic reactions. #autochem https://doi.org/10.26434/chemrxiv-2025-73xqf

A Flexible and Affordable Self-Driving Laboratory for Automated Reaction Optimization

Self-driving laboratories (SDLs) have the potential to revolutionize chemical discovery and optimization, yet their widespread adoption remains limited by high costs, complex infrastructure, and limited accessibility. Here, we introduce RoboChem-Flex, a low-cost, modular self-driving laboratory platform designed to democratize autonomous chemical experimentation. The system combines customizable, in-house-built hardware with a flexible Python-based software framework that integrates real-time device control and advanced Bayesian optimization strategies, including multi-objective and transfer learning workflows. RoboChem-Flex supports both fully autonomous closed-loop operation and human-in-the-loop configurations, enabling seamless integration with shared analytical equipment and minimizing entry barriers. We validate the versatility of the platform across six diverse case studies, including photocatalysis, biocatalysis, thermal cross-couplings, and enantioselective catalysis, spanning both single and multi-objective optimizations. Through these campaigns, we demonstrate RoboChem-Flex’s ability to navigate large, complex chemical spaces, autonomously identify scalable high-performance reaction conditions, and flexibly adapt to a variety of analytical setups. By providing an affordable, scalable, and open platform, RoboChem-Flex offers a tangible step toward making SDLs accessible to resource-limited laboratories, fostering broader participation in automated chemical research.

chemrxiv.org