Noelle Dwyer

@noelledwyerphd.bsky.social

Neural Developmental and Cell Biologist. My lab studies how neural stem cells build the brain. Cell division, cilia, cytoskeleton, neurogenesis. Mom, feminist, curious person. Opinions are my own.

In have made an effort to comment—more calmly and objectively that I through possible—on the proposed OMB changes. There are extremely strong non-partisan arguments that can be made. I urge my scientific friends to take the time and comment as well.

Colette Delawalla, PhD@cdelawalla.bsky.social · 2mo ago

So, if there are shenanigans we can fight for people as a group rather than people fighting for their individual comments. We have full records and are monitoring it nearly hourly at this point. Here is our public comment portal: fight2win.standupforscience.net/campaign/163...

Our article in MBoC is now available in full text as HTML or formatted PDF! Lots of data added since the preprint! Double KO of Cep55 and p53 disrupts epithelial structure with "frankenstein" undead cells: www.molbiolcell.org/doi/full/10....

Molecular Biology of the Cell (MBoC)

molbiolcell.org

Noelle Dwyer @noelledwyerphd.bsky.social · 4mo ago

Our latest #abscission paper is online at MBoC www.molbiolcell.org/doi/10.1091/... . We looked at what happens when there are stochastic abscission failures in a polarized epithelium in vivo. 1/6

Job Alert! I am recruiting a postdoc (and soon a lab tech) to study the functional morphology and biomechanics of walking-like behaviors in fishes at the University of Virginia. Details at: jobs.virginia.edu/us/en/job/R0.... Ads for postdoc+lab tech on salamander locomotion grant coming soon! 🧪🐟🦎

Research Associate in Biology in Charlottesville, Virginia, United States of America | Research at University of Virginia

Apply for Research Associate in Biology job with University of Virginia in Charlottesville, Virginia, United States of America. Research at University of Virginia

jobs.virginia.edu

Reposting today since Bluesky was weird yesterday. Also for #fluorescencefriday image of green cilia on apical membranes of neural stem cells. See our new preprint for details! www.biorxiv.org/content/10.6...

a sheet of epithelial cells outlined in red in a honeycomb pattern, and primary cilia labeled in green
Noelle Dwyer @noelledwyerphd.bsky.social · 4mo ago

Our preprint about Togaram1 mouse knockout brain phenotypes is on bioRxiv! This is a model of Joubert Syndrome ciliopathy caused by loss of Togaram1 (aka Crescerin1 aka FAM179B). Primary #cilia defects in neural stem cells. Neurogenesis, mitotis, apoptosis, morphogenesis phenotypes! #cellbio

Our preprint about Togaram1 mouse knockout brain phenotypes is on bioRxiv! This is a model of Joubert Syndrome ciliopathy caused by loss of Togaram1 (aka Crescerin1 aka FAM179B). Primary #cilia defects in neural stem cells. Neurogenesis, mitotis, apoptosis, morphogenesis phenotypes! #cellbio

mouse embryo with small brain and small eye
bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · 4mo ago

Microtubule binding protein Togaram1 is required for proper development of mammalian forebrain and neural primary cilia https://www.biorxiv.org/content/10.64898/2026.04.13.717734v1

Worth reading for possible explanations and their suggested experiments in Discussion. Note that peer review time was defined as the time from submission to acceptance, so includes time spent on revisions. Would have liked to see that separated out.

Siegenthaler Lab@siegenthalerlab.bsky.social · 6mo ago

"Biomedical and life science articles by female researchers spend longer under review" from @plosbiology.org. After I read this sentence, I counted & I have 43 papers w/ a female first and/or last author. Lots of time wasted in longer reviews/revisions. 😕 journals.plos.org/plosbiology/...

Even though, for each manuscript, time under review is only 7–15 days longer for female- than for male-authored articles (Fig 2), accumulated over a woman’s career, these delays can be very substantial. For instance, for every 50 papers published by a female author, she will have spent on average 350–750 days longer than her male counterparts waiting for reviews and editorial decisions and/or revising manuscripts.

Happy to announce that our latest paper is now out! Have you ever wondered how neural tissues control their size? In this paper, we show that cell division orientation is critical in both the cortex and retina. www.science.org/doi/10.1126/...

Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species

A fundamental role for division orientation in progenitor output driving cortical and retinal growth is revealed.

science.org