Celebrate #ColoringBookDay on August 2 at PDB-101 with the "Discovering Biology Through Crystallography" Coloring Book pdb101.rcsb.org/lear...

It’s time for the World Cup final with one of the greatest footballers that may be playing his last cup So time for a short thread on a link between Messi and an intrinsically disordered protein. 1/n

🔬 Paula Booth – Anfinsen Award Congrats to Paula Booth (King’s College London), 2026 Christian B. Anfinsen Award winner! A pioneer in membrane protein folding and kinetics, her work has shaped the field for over 30 years. #ProteinScience #PS40

Exciting PhD positions at King’s, Leeds, and NPL are now available through the new UKRI:BBSRC Engineering Biology for Biomedicine (#EB4BM) centre for doctoral training. 🗓️ Apply by 9 March Details of our project here: eb4bm.org/project/engi... #PhD #SyntheticBiology #EngineeringBiology

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.

Sequence and chemical specificity define the functional landscape of intrinsically disordered regions - Nature Cell Biology

Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...

nature.com

Alex Holehouse@alexholehouse.bsky.social · 2y ago

We’re pleased to share our substantially updated (more below on that…) version of our manuscript exploring the relationship between conservation in sequence/function for intrinsically disordered regions (IDRs) www.biorxiv.org/content/10.1...

King’s spinout Nuclide Therapeutics is pioneering a new radioactive treatment targeting cancers that resist chemo and radiotherapy. A £5m investment will now fund its first clinical trial in lung cancer patients. www.kcl.ac.uk/news/kings-s... #WorldCancerDay

How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵 Preprint here!: www.biorxiv.org/content/10.6... @cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social #Rubisco #PhaseSeparation #Condensates #Pyrenoid

Solution NMR goes big: Atomic resolution studies of protein components of molecular machines and phase-separated condensates, Alexander I.M. Sever, Rashik Ahmed, Philip Rößler, Lewis E. Kay* @lek-lab.bsky.social @utoronto.ca www.sciencedirect.com/science/arti... #NMRchat 🧲

Solution NMR goes big: Atomic resolution studies of protein components of molecular machines and phase-separated condensates

The tools of structural biology have undergone remarkable advances in the past decade. These include new computational and experimental approaches tha…

sciencedirect.com

Now published! Big congrats to first author @gginell.bsky.social We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions. www.science.org/doi/10.1126/...

Sequence-based prediction of intermolecular interactions driven by disordered regions

Intrinsically disordered regions (IDRs) in proteins play essential roles in cellular function. A growing body of work has shown that IDRs often interact with partners in a manner that does not depend ...

science.org

Alex Holehouse@alexholehouse.bsky.social · 2y ago

Excited to share new work from Garrett Ginell et al where we present an approach for predicting intermolecular interaction driven by disordered regions. We focus on how chemical complementarity can contribute to and even dictate intermolecular interactions www.biorxiv.org/content/10.1...

New paper out! Why do condensates prefer some surfaces and not others? Check it out here: doi.org/10.1063/5.02...

Intrinsic hydrophobicity of IDP-based biomolecular condensates drives their partial drying on membrane surfaces

The localization of biomolecular condensates to intracellular membrane surfaces has emerged as an important feature of sub-cellular organization. In this work,

doi.org

10 years! 🎉 Time flies. Reflecting on a decade since this was published: www.sciencedirect.com/science/arti...

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

Cells chemically isolate molecules in compartments to both facilitate and regulate their interactions. In addition to membrane-encapsulated compartmen…

sciencedirect.com

We're looking for a #postdoc to join our team at KCL Chemistry @kingsnmes.bsky.social. If you're interested in disordered proteins, please get in touch! 3 year post. Ad closes 12 March: www.kcl.ac.uk/jobs/105866-...

Postdoctoral Research Associate in Disordered Protein Interactions

kcl.ac.uk

Join us for the #BurtonLecture25! 🌟⁠ We are thrilled to welcome Prof Charlotte Williams OBE FRS, @ox.ac.uk, who will explore how polymers can be redesigned to reduce greenhouse gas emissions. 📅 3 Apr, Thu ⏰ 17.00 - 20.00 📍SE1 1UL Register ⬇️

Burton Lecture 2025

Please join us in-person and online for the annual Burton Lecture at King's College London with Professor Charlotte Williams OBE FRS.

buff.ly

Self-healing #potholes could pave the way for sustainable roads. Joint research by kingsnmes.bksy.social, swanseauni.bsky.social and Google Cloud is tackling the UK’s £143 million pothole problem. 👉 www.kcl.ac.uk/news/self-healing-potholes-pave-the-way-for-more-sustainable-roads #ScienceAtKings

New review / perspective with @albertilab-tud.bsky.social on our thoughts on condensate speciality and recruitment, focusing on interplay between site specific and chemically specific interactions www.cell.com/molecular-ce...

Molecular determinants of condensate composition

Biomolecular condensates are non-stochiometric assemblies that organize cellular matter in space and time. Despite much work, many questions remain regarding what determines the recruitment and exclus...

cell.com

Join us for the Wheatstone Lecture 2025 !🌟 Prof Hagan Bayley, @ox.ac.uk, will delve into the fascinating world of nanopores – tiny protein structures revolutionising DNA sequencing and tissue engineering. 📅 26 Feb 2025 ⏰17:00 - 19:30 📍Strand Campus Register ⬇️ www.eventbrite.co.uk/e/wheatstone...

What #chemistry is needed for life to begin? And what signs of life should we be looking for in the #universe to learn if we are alone? 🪐 Dr Saidul Islam, from @kingsnmes.bsky.social discusses the habitability of planets with @bbcradio4.bsky.social #InOurTime. 👇 www.bbc.co.uk/programmes/m...

BBC Radio 4 - In Our Time, The Habitability of Planets

Melvyn Bragg and guests discuss ideas about where life may begin in the universe and how.

bbc.co.uk

A look at just how disordered a disordered protein-protein pair can get. Do they even care about stereochemistry any more?

Now That's What I Call Disordered

science.org