New to me and I found 2! I love finding successional fungi, fungi growing on fungi. This has to be one of the more unique I've found. I believe these are Asterophora lycoperdoide, or the Powdery Piggyback Mushroom! More ⬇️ #Parasite #FungiFriends #Fungi #Nature #Guttation

I’m very excited to share the first big project from my PhD (my first proper-first, yay!) where we use cryoET and a fun new flavour of CLEM to study the re-organisation of photosynthetic machinery of cyanobacteria growing beyond the red limit of light. doi.org/10.64898/202...

academic.oup.com/plphys/artic...

Carbonic anhydrase activity under low zinc in Phaeodactylum tricornutum largely depends on metal-free iota-carbonic anhydrase

Abstract. Carbonic anhydrases (CAs) typically possess a Zn2+ cofactor and are involved in a wide range of adaptive metabolisms involving pH and dissolved i

academic.oup.com

www.biorxiv.org/content/10.6...

Fluorescent Biosensors for Cryogenic Correlative Light and Electron Microscopy

Cryogenic electron tomography provides nanometer-scale views of subcellular structures but lacks essential physiological context, such as the metabolic state or ion concentration. To bridge this gap, ...

biorxiv.org

Struggling to choose a pixel size for your cryo-ET acquisition? Worry not: super-resolution processing can take in situ subtomogram averaging beyond physical Nyquist! We reached 2.8 A loc-res of a ribosome dataset with 4.78 A physical Nyquist limit! Our new preprint 👇: doi.org/10.64898/202...

Shawn Zheng leads Biohub’s work to streamline cryo-electron tomography, which images cells in 3D at near-atomic resolution. His team’s AreTomoLive automates cryoET reconstruction and denoising in real time and cuts processing from months to days. Learn more: sbgrid.org/software/tal...

In their Cell Science at a Glance article and associated poster, @phaips.vd.st, Benjamin Engel @cellarchlab.com & @manondemulder.bsky.social highlight the current insights and future directions of pyrenoid and CO2-concentrating mechanism research. journals.biologists.com/jcs/article/...

Intrigued how #biomolecularcondensates evolve? Want to work with a condensate system that has a global impact? We’re recruiting a 4-year PDRA to explore the evolution of CO2-fixing pyrenoids: www.jobs.ac.uk/job/DTE394/r... Please repost. #pyrenoids #photosynthesis

And your regular reminder of the innumeracy of this metric (a pseudo mean calculated from two different datasets and applied to a non-normal distribution) www.biorxiv.org/content/10.1...

Nice @jcellsci.bsky.social "at a glance" review about the convergently evolved organizing principles of pyrenoids, chloroplast compartments that enable diverse algae to supercharge #CO2 fixation. BONUS: It comes with a poster for your wall 🖼️. Great work @phaips.vd.st & @manondemulder.bsky.social 🌊🌾🧪

Manon Demulder@manondemulder.bsky.social · 4w ago

If you’ve always been curious about how algae fix carbon, @phaips.vd.st, @cellarchlab.com and I have put together the quickest route into pyrenoids. And if you don’t feel like reading at all, we have an accompanying poster doi.org/10.1242/jcs....

What even is a pyrenoid? Check it out 👇

Manon Demulder@manondemulder.bsky.social · 4w ago

If you’ve always been curious about how algae fix carbon, @phaips.vd.st, @cellarchlab.com and I have put together the quickest route into pyrenoids. And if you don’t feel like reading at all, we have an accompanying poster doi.org/10.1242/jcs....

🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET

Great success for the 2nd edition of the Young Swiss Tomo Meeting in Bern 🔬, co-organized with the DCI, and @leonieanton.bsky.social, Elsa Bauda, @zanettakechagia.bsky.social and Agnes Moe who's joining the team for the next edition. Thanks to @dectris.bsky.social and @thermofishersci.bsky.social ..

The PhD and Postdoc application links are now live! Come join me at UNIL to work on deep learning for protein structure, interactions & design. pickybinders.org#open-positions

Janani Durairaj (Jay)@ninjani.bsky.social · 2mo ago

Some exciting news: I'm joining the University of Lausanne @unil.bsky.social @dbc-unil.bsky.social as an Assistant Professor next month 🎉 My group will work on context-aware deep learning for protein structure, interaction & design. Postdoc and PhD openings coming soon - keep an eye out!

A wild publishing ride to get here... but finally! (first bioRxiv: January 5th, 2024 🙃) Amazing work from @lorenzlamm.bsky.social and colleagues 🤗 Special thanks to the community who jumped early on the boat, sharing feedback and training data to make MemBrain v2 a reality 🙏🏽

MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography - Nature Methods

MemBrain v2 enables streamlined analysis of membranes in cryo-electron tomography by providing user-friendly tools for membrane segmentation, membrane protein localization and spatial analysis, suppor...

nature.com

Can we predict the stoichiometry of proteins in a complex from their sequences - fast and accurately? Congratulations to the #ECCB2026 🧬 proceedings paper award 🎉 @daniil-litvinov.bsky.social @ninjani.bsky.social @cellarchlab.com academic.oup.com/bioinformati...

Unsupervised machine-learning identifies latent pyrenoid states linked to mitotic remodeling defects and CO2-dependent growth https://www.biorxiv.org/content/10.64898/2026.08.25.746929v1

Remember this? bsky.app/profile/did:... Rigorous visualization of the structure in your high-dimensional data. Fantastic work by @dhdegroot.bsky.social With help of the reviewers of Nat Biotech it is now updated, extended an officially published here: www.nature.com/articles/s41... 1/n

Bonsai reconstructs tree representations for distortion-free visualization and exploration of high-dimensional data - Nature Biotechnology

High-dimensional data are visualized through representation on tree structures.

nature.com

Erik van Nimwegen@erikvannimwegen.bsky.social · last yr.

Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social. I'm so excited about this! www.biorxiv.org/content/10.1...

Lateral organization of cytochrome b6f in thylakoid membranes controls photosynthetic electron transfer efficiency www.biorxiv.org/content/10.6...

Lateral organization of cytochrome b6f in thylakoid membranes controls photosynthetic electron transfer efficiency

Photosynthetic electron transfer relies on the coordinated function and spatial organization of large protein complexes within the thylakoid membrane. The cytochrome b6f complex (b6f) functionally int...

biorxiv.org

As a component of aseptic technique, Bunsen burners do not universally decrease deposition of microbe-containing particles journals.asm.org/doi/full/10.... #jcampubs

Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...

It’s either that, or In Situ Plus, In Situ Pro, In Situ Ultra, and In Situ Max. With Max reserved strictly for when you put an entire frozen human in the TEM (is anyone working on that yet?)

We've been seeing a lot of "in situ" lately in titles from fancy journals (not pointing any fingers 👀). I’ve delayed posting this, but as more and more come out, I'm afraid "in situ" is becoming an empty buzzword, much like "near-atomic" was for SPA 🔬 1/n #cryo-ET #cryo-EM #cryoET #cryoEM 🧪

Why do intrinsically disordered proteins behave so weirdly during SDS-PAGE? This is the question we aim to answer in our recent paper: onlinelibrary.wiley.com/doi/10.1002/...

Sequence determinants of the hypomobility of intrinsically disordered proteins in <fc>SDS</fc>‐<fc>PAGE</fc>

Proteins with intrinsically disordered regions (IDRs) migrate at a higher apparent molecular weight in sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis, complicating their analysis and...

onlinelibrary.wiley.com

🚀 New preprint 🥳 Fantastic work by our recent PhD graduate Daan ! How are mRNPs remodeled as they exit the nucleus? We identify PAIP1 as a factor that promotes exchange of the nuclear poly(A)-binding protein PABPN1 for cytoplasmic PABPC1, coupling mRNA export to cytoplasmic mRNP maturation.

bioRxiv Molecular Biology@biorxiv-molbio.bsky.social · 3mo ago

PAIP1 couples mRNA export to cytoplasmic mRNP remodeling and poly(A) homeostasis https://www.biorxiv.org/content/10.64898/2026.07.31.742013v1

The artist formerly known as #thatmitoriboguy has now become #thatchlororiboguy Check out some cool tomo from @florentwaltz.bsky.social @phaips.vd.st

Florent Waltz@florentwaltz.bsky.social · 3mo ago

This story is now published in @natplants.nature.com ! 🎉🎩 Check out the final article here: nature.com/articles/s41477-026-02361-1 Very similar to the original bioRxiv preprint, with the addition of some cool polysome analysis (in the supplementals)! Thanks and congrats to everyone involved! 🙏

And 2 complementary 📜: 1️⃣ Cyanobacterial & vascular plant chlororibos🌿 (by @michaelwebster.bsky.social, with contrib from @sofie-dot-rec.bsky.social, @cellarchlab.com & I): biorxiv.org/content/10.64898/2026.07.03.736309v1 2️⃣ Marchantia chlororibos 🥬: biorxiv.org/content/10.64898/2026.07.14.738477v2

This story is now published in @natplants.nature.com ! 🎉🎩 Check out the final article here: nature.com/articles/s41477-026-02361-1 Very similar to the original bioRxiv preprint, with the addition of some cool polysome analysis (in the supplementals)! Thanks and congrats to everyone involved! 🙏

Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome - Nature Plants

Using in situ cryo-electron tomography, researchers found a unique ‘arm’ domain on the small subunit of Chlamydomonas chlororibosomes. This discovery suggests that chlororibosome structure is more evo...

nature.com

Florent Waltz@florentwaltz.bsky.social · 9mo ago

Long in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖: shorturl.at/q44tG This suggests greater chlororibosome diversity than expected! 1/n 🧵

Regulatory logic of the Chlamydomonas CO2-concentrating mechanism: coupling carbon flux, energy supply, and pyrenoid architecture www.frontiersin.org/journals/pla...

Frontiers | Regulatory logic of the Chlamydomonas CO2-concentrating mechanism: coupling carbon flux, energy supply, and pyrenoid architecture

The algal CO2-concentrating mechanism (CCM) elevates CO2 around Rubisco, the CO2-fixing enzyme, through the coordinated action of inorganic carbon (Ci) uptak...

frontiersin.org