🧬 Ever found yourself scrolling straight past the methods section? Omics datasets are now routine in immunology. Learn to analyse and visualise them with our beginner-friendly bioinformatics course. Starts 14 Sept or 7 Dec. Self-paced also available 🔗 vist.ly/5d4z2

Altered B-cell homeostasis and elevated IL10/TNFA expression in #CIDP suggest chronic humoral immune activation. Immune markers also correlated with nerve fiber loss and disability, highlighting potential biomarkers of disease activity. vist.ly/5d68e #Neurology #Neuroimmunology

Disease activity in chronic inflammatory demyelinating polyneuropathy: association between circulating B-cell subsets, cytokine levels, and clinical outcomes

B-cell homeostasis is significantly altered in chronic inflammatory demyelinating polyneuropathy (CIDP) and is not reversed by immunomodulatory treatments.

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Regulatory B cells (Bregs) help maintain immune tolerance, but their roles in autoimmune disease are remarkably diverse. This review explores how Breg phenotypes and functions vary across conditions and what that means for future therapies. 🔗 vist.ly/5d4vc

Heterogeneity of regulatory B cells in autoimmune diseases: implications for immune equilibrium and therapeutic strategies

Abstract. Regulatory B cells (Bregs) play a crucial role in maintaining immune tolerance and preventing autoimmune diseases. However, in autoimmune conditi

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PI3K hyperactivation is a key driver of APDS and related immune disorders. This review explores disease mechanisms, diagnostic strategies, targeted treatments, and remaining clinical challenges. vist.ly/5d68s #IEI #Immunology #PrecisionMedicine

Hyperactivation of the PI3K pathway in inborn errors of immunity: current understanding and therapeutic perspectives

Abstract. The phosphoinositide-3-kinase (PI3K) pathway function is crucial to the normal development, differentiation, and function of immune cells includi

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Radiolabeled nanobodies are emerging as powerful tools for cancer imaging, offering rapid target detection and high target-to-background contrast. Explore their growing role in supporting cancer diagnosis and immunotherapy monitoring. 🔗 vist.ly/5cyc9 #CancerResearch

How does BCG vaccination affect NK cells? This study found increased NK cell frequency in draining lymph nodes following vaccination, with no significant changes in their spatial organisation. 🔗 vist.ly/5cybd

T-cell integrins play a central role in immune cell trafficking, tissue retention, and inflammation. This review examines how targeting these molecules is shaping treatments for autoimmune and inflammatory diseases, including IBD, multiple sclerosis, and psoriasis. 🔗 vist.ly/5cycj

Targeting T-cell integrins in autoimmune and inflammatory diseases

Activated T cells bind to the endothelium using activated integrins as part of the multi-step process of extravasation. The expression of specific repertoi

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Starting university or further education this autumn? If you're eligible, don't miss this time-limited opportunity to get protected against MenB disease before term starts. Check the UKHSA guidance below to see if you're eligible and book your vaccination here: t.co/i3A7zwLyJW

UK Health Security Agency@ukhsa.bsky.social · 2mo ago

🆕 A free 2-dose MenB vaccine will be available for a limited time from end of July. Who can have it: 🏫 All current Year 13s 🧑‍🎓 Anyone either starting university as an undergrad or moving into further education halls for the first time in autumn 2026, aged under 25

Do sign up for the first of the BSI’s AI in immunology courses

British Society for Immunology@britsocimm.bsky.social · last wk.

Searching the literature? Writing grants? Analysing omics data? Learn how to build an AI research assistant in our new 1 day course on 21 Oct 2026. No coding experience required #AIForBiosciences 🎓 Discount for BSI members. Book now before places fill! vist.ly/5ctxw

🔬 New research suggests that individuals exposed to Mycobacterium tuberculosis without developing active disease have stronger IgA and IgG antibody responses than TB patients. High salivary IgA levels also point to an important role for mucosal immunity in TB protection. vist.ly/5cuf7

New open‑access study by Maria Z. Krauss et al. shows how amino acid uptake and mTOR signalling in CD4⁺ T cells power immunity to Trichuris muris. SLC7A5 proves essential, and loss of mTOR leads to chronic infection. 🔗vist.ly/5cvng

🔬 New open‑access research shows how T‑cell signals (CD40L & IL‑4) can reduce NK‑cell ADCC against malignant B cells, revealing a resistance mechanism to anti‑CD20 therapy. Combining anti‑CD20 + anti‑NKG2A may overcome it. Read: vist.ly/5cvmh

What opportunities can research create for nurses beyond the clinic? #BSICIPN #ClinicalResearch Consultant Nurse Lucy Common discusses how research has shaped her career, influenced national guidance through NICE, and why it should be recognised as a core part of nursing. Watch now: vist.ly/5cppi

Need funding to attend your next conference? 💡 The BSI Conference Travel Grants can cover your travel costs - UK (£500), Europe (£700), rest of world (£1,000). The deadline is less than 1 week away (1 August), so submit your application soon! https://bit.ly/3U0jk2E

🧬 New research suggests G-CSF supportive care may come with an immunological trade-off: improved neutrophil recovery but reduced checkpoint blockade efficacy in immunotherapy-responsive pancreatic cancer models. vist.ly/5cr86 #PancreaticCancer #Immunotherapy #Oncology #CancerResearch

Growth factor supportive care for chemotherapy-induced neutropenia suppresses antitumour immunity in checkpoint blockade-responsive pancreatic cancer

AbstractIntroduction. Growth factors, including granulocyte colony-stimulating factor (G-CSF; pegfilgrastim, filgrastim), are used for prophylaxis or treat

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🐖 New research shows pigs generate both strain-specific and broadly reactive influenza antibodies, including stem-targeting mAbs with cross-subtype recognition. A valuable tool for understanding influenza immunity and improving vaccine design. 📖 vist.ly/5ck5w

Master complex multiparameter flow cytometry with confidence! Join our course led by trainer Derek Davies & learn how to design robust experiments, troubleshoot issues & generate reliable data using real immunology examples. 📆 13 & 20 Oct! Register now: vist.ly/5cj9h

You don't have to wait for a course date to build your bioinformatics skills. Our self-paced bioinformatics courses are available wherever you're based, so you can start learning when you need to and progress at your own pace. Explore the courses: vist.ly/5c8wg

Advance your #bioinformatics skills this autumn! Our Single cell and spatial omics course runs every Monday from 12 October to 9 November 2026. For wet lab scientists with basic R skills. Rated 9.5/10 by over 3,000 attendees! Book now: vist.ly/5cbjr

🔬 Radiolabeled nanobodies are emerging as powerful tools for cancer immunotherapy, enabling non-invasive imaging of tumours, immune checkpoints, and immune cells to support patient selection and treatment monitoring. 📖 vist.ly/5c72w

🔬 New evidence suggests β-tubulin 5 (TBB5) is unlikely to be the pANCA target in primary sclerosing cholangitis (PSC), narrowing the search for the underlying autoantigen. 📖 vist.ly/5c73w #Immunology #Autoimmunity

💊🧫 Antibiotics can do more than kill bacteria. This study shows that the fluoroquinolone levofloxacin directly alters macrophage biology, driving mitochondrial hyperpolarization and modulating iNOS expression in specific monocyte-derived macrophage populations. 📖 vist.ly/5c7t7

Fluoroquinolones directly drive mitochondrial hyperpolarization and modulate iNOS expression in monocyte-derived macrophage populations

AbstractIntroduction. The fluoroquinolone levofloxacin is often selected for use prophylactically as well as during respiratory infections. However, studie

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🧬 Innate lymphoid cells are emerging as key players in cancer immunity. This review explores the diversity, plasticity, and anti-tumour functions of type 1 innate lymphoid cells (ILC1s), with a focus on the immune checkpoint receptor PD-1. 📖 vist.ly/5c3ub #Immunology

🧬 New insight into rituximab resistance: CD40L and IL-4 shield B cells from NK cell-mediated killing via the HLA-E/NKG2A and HLA/KIR inhibitory pathways. Targeting these checkpoints could enhance B-cell depletion in autoimmune disease. 📖 vist.ly/5c37t

🧬 CAR-T cells and TCR-T cells don't regulate cytokine production in the same way. Patel and colleagues show that while co-stimulatory receptors are needed to sustain late cytokine production in TCR-T cells, this regulation is largely lost in 2nd-generation CAR-T cells. 📖 vist.ly/5c3w8

How do the best research questions arise? Dr Fatima Dhalla discusses why clinical immunologists are uniquely placed to identify the questions that matter most to patients, and how research can complement a clinical career. Watch the full interview: vist.ly/5c3uy

Could the environment hold the key to better immune therapies? 🌍 #LIG26 Join us in London this September to explore how diet, the microbiome, pollution and stress influence immunity, and open new avenues for prevention and treatment. Register now: vist.ly/5c345

What does research look like alongside a clinical career? #BSICIPN #ClinicalResearch Over the coming weeks, we'll be sharing a new interview series featuring professionals from across the clinical immunology community. The first interview with Dr Fatima Dhalla launches tomorrow! Keep an eye out 🙂

📢 Programme update! We're delighted to welcome Prof Adrian Hayday as the keynote speaker for #BSI26. His pioneering research has transformed our understanding of gamma delta (γδ) T cells & their role in cancer, inflammation & tissue immunity. Read more: vist.ly/5byyj