It‘s been a pleasure to host @mucubacter.bsky.social as a guest speaker for the CRC1371 #microbiomesignatures here at #TUM. Fantastic talk on #microbiome #diet #antibiotic and #mucus projects, and great exchanges! Thank you for your visit Björn! #mucusmatters

RESEARCH | @ocoleman.bsky.social , Sorbie, Haller et al. (TUM) ATF6 causes an enrichment in long-chain fatty acids in the colon, which contributes to the development of colorectal cancer🧪

ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature Metabolism

The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal cancer in humans and mice, thereby linking endoplasmic reticulum stress responses to lipid metabolism and tumorigenesis.

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I recently had the pleasure of a short stay at the University of Gothenburg, hosted by Elisabeth Nyström. Many thanks to Liz and everyone in the Mucin Biology groups for the warm welcome and stimulating scientific exchange. Looking forward to continuing our collaboration! #mucusmatters

@ocoleman.bsky.social way to go!

Technische Universität München@tum.de · last yr.

Researchers identified a #cellularmechanism that alters the #gutmicrobiome in a way that promotes #cancer. The study could demonstrate the increased formation of long-chain #fattyacids – the preferred food of certain cancer-promoting #bacteria: go.tum.de/864170 📷A.Eckert

@ocoleman.bsky.social way to go!

Eric Chevet@ericchevet.bsky.social · last yr.

This week selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation www.nature.com/articles/s42...

For an extra read on our new publication in #naturemetabolism, read my Blog Post: Unravelling how the stress sensor ATF6 stirs up trouble (and tumors) communities.springernature.com/posts/unrave... #lifesciences #colorectalcancer #microbiota #erstress #metabolism

Very happy to share our latest publication unravelling how the #ERstress sensor ATF6 stirs up trouble (and tumors) in #colorectalcancer. ATF6 drives CRC by reshaping lipid #metabolism and the intestinal #microbiota. A huge thank you to all co-authors! #lifesciences www.nature.com/articles/s42...

ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature Metabolism

The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal ca...

nature.com

🚀 What’s it like to launch a new lab? Hans-Georg Sprenger shares challenges, early wins & the joy of mentoring in molecular metabolism research. @mpiage.bsky.social Read the interview: febs.onlinelibrary.wiley.com/doi/10.1002/... #ScienceCareers #Mentoring #ResearchLife

Road trip starts tomorrow. Journal proofs still MIA. Guess the laptop’s coming after all… #academiclife #firstauthorpriviliges

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ALT: a man wearing headphones sits at a desk with a laptop on it on the beach

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This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥 www.nature.com/articles/s42...

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism

This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

nature.com

This isn't the crispest image, unfortunately, but getting my mouse intestinal organoid to take on the shape of a mouse (nibbling on a chow pellet?) is my achievement of the week 🤩 p.s. @gobletcellguy.bsky.social: this is the mCherry Muc2...the signal is definitely there 🤜

Happy to share our latest paper showing that intestinal inflammation (IL10-/-) + an UPRER diva protein (ATF6) = a perfect storm for colon cancer: Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer. academic.oup.com/ecco-jcc/art...

Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer

AbstractBackground and aims. Chronic inflammation in inflammatory bowel disease (IBD) patients represents a risk factor for developing colitis-associated c

academic.oup.com

The 5th Ghent Gut Inflammation Group Meeting #GGIG2025 is live! 🚨 Hosted by Ghent University & VIB, this 2-day event spotlights junior scientists in gut research. Great start with Jochem Bernink of @amsterdamumc.bsky.social on immune-mediated regeneration in the gut! More info: vibbio.tech/GGIG2025

Happy to see this finally published 🙌 Thanks to the editors and reviewers for the constructive process 😎

Journal of Experimental Medicine@jem.org · 2y ago

The colonic mucus barrier & sentinel goblet cells protect the distal gut from microbial challenges. Johansson, @gobletcellguy.bsky.social et al show that microbial colonization drives sequential development of both of these barrier mechanisms in the pre-weaning intestine. rupress.org/jem/article/...

It‘s been a pleasure to host @mucusman.bsky.social as a guest speaker for the CRC1371 #microbiomesignatures here at #TUM. Two days filled with productive and fun #gobletcell exchanges and a fantastic talk on #mucus #autphagy #erstress and #antibiotics. Thanks for making the trip Shai! #mucusmatters

For all the #mucus fans out there who believe in our knight in slimy armour and want to join the starter pack 👇 contact @gobletcellguy.bsky.social #mucusmatters

George Birchenough@gobletcellguy.bsky.social · 2y ago

Just in case any new #mucus, #Goblet cell or #mucin folks have joined up recently, we have a small but growing starter pack for this area - let me know if you want in 🫡 go.bsky.app/7Z84CmG

Better late than never...finally made the move to #bluesky! I am back from #maternityleave and excited to dive into the science world again, and catch up on #mucus updates ✌️ I've probably missed lots 😱 #mucusmatters #academicchatter #academicmum

a man standing in a hallway with the words listen i know i 'm late i can explain

ALT: a man standing in a hallway with the words listen i know i 'm late i can explain

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