🚨 New version of GlycoShape is now live at glycoshape.org 🥳 Powered by crabWURCS everything runs on your browser and while you save all you ReGlyco work and go back to it whenever you like 😎 Among other new things: new slick drawer, much easier to use, new slick SNFG representations and new layout
Isn't it amazing when a fresh new preprint is out on Friday? 😎🥳 Check out the fabulous work by @beatricetropea.bsky.social who gives us a clear mechanistic explanation behind the 'peculiar' structure of the LLO donor preferentially chosen by eukaryotic OST 🤓😍 doi.org/10.64898/202...
Excellent #glycotime in Bratislava for the #ICS2026 great catching up with so many amazing colleagues and friends about science, @glycoshape.org and all the fun stuff! 🥳 We had a fabulous time 😎
Un-crystallisable glyco-complexes anyone? New work led by John Klassen's lab introduces antibody masking-native mass spectrometry (AM-nMS) a spatially resolved assay that allowed us to map glycan binding sites across the SARS-CoV-2 RBD. The results match our MDs! 😜 All details glycoshape.org/blog
glycoshape.org has now a blog where we discuss (yep you got it) glycans, glycoproteins and fun stuff! Season 1 is out with: Ep01: Why should we care about glycan heterogeneity? Ep02: How can we include glycan heterogeneity in a 3D framework? Ep03: Molecular precision glycoscience: Enter Siglecs
Next time you hear 'glycans are just a fancy protein decoration' 😱 show them this fabulous work led by Katrine Schjoldager and team at the CGR 🇩🇰 with us 🇬🇧 showing how The ligand preference of LRP1 is regulated by O-glycans Out now www.science.org/doi/10.1126/... 🧵1/10 ⬇️
The ligand preference of LRP1 is regulated by O-glycans
GALNT11-mediated O-glycans modulate LRP1 uptake of tau and Aβ, unveiling glycan-driven mechanisms in neurodegenerative pathways.
science.org
Carbohydrate-binding is a small profit affair, so proteins often adopt complex multidomain architectures enabling a mechanism known as 'binding cooperativity', where binding to one monomer contributes to the binding affinity of the whole systems BUT how does it actually work? 🔥 #glycotime 🧵1/4 ⬇️
Alexis Rose: I Don't Know You Tell Me (Schitt's Creek)
ALT: Alexis Rose: I Don't Know You Tell Me (Schitt's Creek)
static.klipy.com
Glycoheterogeneity is an aspects of glycobiology that most would class into a category between difficult and intolerable, but @benschulz.bsky.social and us love it! So we wrote a whole review in Current Opinion in Structural Biology on it 🧵1/8 ⬇️ doi.org/10.1016/j.sb...
Ben @benschulz.bsky.social , Ojas @ojas-singh.bsky.social and I have been pondering about heterogeneity a lot lately 🤔 In this COSB review we discuss the fruits of our pondering, discussions and readings, and we share our awe for the power and ingenuity of glycoheterogeneity in a 🧵 @glycoshape.org
GlycoShape@glycoshape.org · 4mo agoGlycoheterogeneity is an aspects of glycobiology that most would class into a category between difficult and intolerable, but @benschulz.bsky.social and us love it! So we wrote a whole review in Current Opinion in Structural Biology on it 🧵1/8 ⬇️ doi.org/10.1016/j.sb...
Glycoproteins can be hard to understand because they're complex, heterogeneous, and flexible. Integrating MS glyco(proteo)mics, structural biology, and molecular dynamics simulation data can help! www.sciencedirect.com/science/arti... @elisafadda.bsky.social @ojas-singh.bsky.social #glycotime
Heterogeneity of glycoproteins: Why does it matter and how to account for it
Glycosylation can be critical for determining the structure and functions of proteins, but it is often neglected, leading to significant knowledge gap…
sciencedirect.com
A fab, sunshiny week in 🇩🇰! Great #glycotime 🧪 at the CBM16 in Helsingør, with posters Bea: regulation of N-glycosylation by OST (doi.org/10.1101/2025...) Silvia: Siglec-6 high-recision recognition of glycolipids (doi.org/10.1038/s420...) Ojas: de novo binders design (doi.org/10.64898/202...) 🧵⬇️
Daily job count is quite high these days after the release of our case study 1 week ago and of the ReGlyco de novo Binder Design Filter notebook ⬇️ doi.org/10.64898/202... and res. therein So exciting to see a growing number of researcher including glycosylation in their studies! 🎉 #glycotime 🧪
The University of Southampton has joined ELIXIR-UK 🎉 From open-access glycan databases to data stewardship, Southampton brings a wealth of expertise to the network. Read more: elixiruknode.org/news/2026/un... @elisafadda.bsky.social @glycoshape.org #openscience #bioinformatics #datastewardship
University of Southampton joins ELIXIR-UK as it newest member
The University of Southampton has joined ELIXIR-UK, bringing expertise in computational biology, bioinformatics, clinical data, and data stewardship.
elixiruknode.org
We are proud to be part of @elixiruknode.org as the @unisouthampton.bsky.social node, and to share our expertise in structural and computational glycoscience 🧪, together with our OA resources thought it. Check out the announcement below for more information ⬇️ 🥳
ELIXIR-UK@elixiruknode.org · 6mo agoThe University of Southampton has joined ELIXIR-UK 🎉 From open-access glycan databases to data stewardship, Southampton brings a wealth of expertise to the network. Read more: elixiruknode.org/news/2026/un... @elisafadda.bsky.social @glycoshape.org #openscience #bioinformatics #datastewardship
We have some fresh and cool #glycotime 🧪 on the impact of including glycosylation explicitly in de novo binder design. Filtering the results of a recent open competition for novel binders to the Nipah Virus Glycoptrotein (NiV-G) with ReGlyco improves the pipeline efficiency significantly ⬇️
GlycoShape@glycoshape.org · 6mo agoMost biologics are glycosylated and some of them heavily. In this “fresh off the press" #glycotime preprint we look into how a filter that accounts for glycosylation explicitly in 3D can help reduce lab costs and increase the efficiency of de novo binder design pipelines. Short 🧵 ⬇️ 1/7
Most biologics are glycosylated and some of them heavily. In this “fresh off the press" #glycotime preprint we look into how a filter that accounts for glycosylation explicitly in 3D can help reduce lab costs and increase the efficiency of de novo binder design pipelines. Short 🧵 ⬇️ 1/7
bioRxivpreprint@biorxivpreprint.bsky.social · 6mo agoIntegrating glycosylation in de novo protein design with ReGlyco Binder Design Filter https://www.biorxiv.org/content/10.64898/2026.04.16.718906v1
Silvia's simulations showed that while all epitopes expose Sia for binding, Siglec-6 recognises and binds only GM1 because of a key interaction with the membrane through W127 and K126, which orientates the V-set domain to bind the Sia through Arg122 and the terminal Gal to the C-C' loop 😎
Happy new year 2026 #glycotime! 🥳 We just introduced some useful options to Re-Glyco Ensemble. In the Advanced Settings you can now select a seed (positive integer) to reproduce structural ensemble of your favourite glycoforms such as the one below that you will see soon in an upcoming paper,
Super interesting work from @carolynbertozzi.bskyverified.social group about the effects of glycosylation in protein structure and function at the proteome scale 🤯💥🤩 Results show that sialylation and fucosylation are crucial, which makes a lot of sense. We did some extra bits 🧐 with GlycoShape ⬇️🧵
Carolyn Bertozzi@carolynbertozzi.bskyverified.social · 10mo agoCongratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏 www.biorxiv.org/content/10.6...
We just did some maintenance and updates to glycoshape.org, ✅ Fancy background with floating SNFG symbols 🤩 ✅ 'Latest Updates' feed from this account on bsky 🤩 ✅ Download PDB with SASA values in Re-Glyco Ensemble 🤩 Check it out!
Hello #glycotime! GlycoShape makes its debut on bsky today 🦋🎉 Follow us for news, updates and fun-facts (I take full responsibility for those, Ojas @ojas-singh.bsky.social 😆) below ⬇️
GlycoShape@glycoshape.org · 11mo agoHello bsky 🦋 GlycoShape is now here to give you updates on our glycan 3D database, toolbox, glyco fun-facts and news! We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬 We'll have great new tools coming up soon, so follow us for some exciting #glycotime
Super excited by our new #glycotime preprint! A long-term project from my group with awesome collaborator @elisafadda.bsky.social Regulation of N-glycosylation efficiency by eukaryotic oligosaccharyltransferase www.biorxiv.org/content/10.1... thread below 👇
a cartoon drawing of a pitcher and cup of sugar on a table
ALT: a cartoon drawing of a pitcher and cup of sugar on a table
media.tenor.com
When glycan recognition is linked to immune response, you need fine tuning! 😎 Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️ doi.org/10.1101/2025...
Registration to our "Structural Glycoscience" Summer School is open !! Come to Grenoble for #glycotime lectures, practicals, visit to @esrf.fr @cermav.bsky.social and IBS. Information and registration at glycoalps.univ-grenoble-alpes.fr/news/summer-...
Glycoshape is 1 year old! 🎂🎁 🎉 Last year today we launched glycoshape.org after extensive consultation with a team of friends and colleagues. As head chef, it is my pleasure and duty to give a few thanks before the toast🥂 1/3
Christmas arrived early for me🎄🎁 just got a hard copy of the Nature Methods Nov 2024 issue with our GlycoShape article in it ❤️❤️ it smells sooo nice!!! 🤩🤣 doi.org/10.1038/s415...
And the best poster award #SfG2024 goes to.....Ojas Singh @ojas-singh.bsky.social for his incredible work on GlycoShape!!!! 🎉🎊🎉🎊🎉🎊 Super congrats Ojas we are suuuper proud of you! #glycotime
