Oscar Marcelo Lazo

@omlazo.science

Broad-spectrum neurobiologist, cancionista, & escribidor de brocha gorda. Dad of three humans, married to their unfathomable mum. I ask questions to neurons and brains at the UCL Queen Square Institute of Neurology 🇬🇧 and Universidad San Sebastián 🇨🇱.

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Random chat last night... — Dad, I'm not vaccinating. They say the HPV vaccine is the most painful one! — Do you know what a papilloma is? — No... — A cause of cancer — x___x — A type of cancer that use to cause a lot of trouble and now you can avoid just getting vaccinated. — Ok

Tengo que hacer algunas clases este semestre. Afortunadamente son algunas de las cosas que más me entusiasman en el mundo, así que simplemente espero poder transferir algo de ese mismo entusiasmo. ¡Se viene el segundo semestre!

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I've been culturing intact explants of embryonic mouse basal forebrain. It's a pretty cool way to model interactions between the different BFN populations in vitro, both in physiology and disease, specially in Alzheimer's where these neurons are particularly vulnerable. [Confocal— DAPI+Phalloidin]

Coming to London on a summer Saturday—when Pride celebrations were in full swing, and everyone was out with friends in all sorts of playful attire—has been absolutely vivifying!

I grew up one little bit today. I'm going back to the lab in London in a couple of weeks, and instead of booking a bed in a noisy backpackers' hostel as usual, I evolved to booking myself a room in a proper family-run hotel next door. Yeahp... getting old.

True that the promising story about jacifusen still requires more data to weight its impact in the real world, but I can't help thinking about the 16-y.o. kid with ALS that after a year of treatment is breathing again and recovering movement. Unprecedented progress! www.thelancet.com/journals/lan...

Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series

The findings suggest the safety and possible efficacy of jacifusen for treating FUS-ALS. The efficacy of jacifusen is being further evaluated in an ongoing clinical trial.

thelancet.com