Very happy to share this Perspective in @natrevimmunol.nature.com www.nature.com/articles/s41...

Connection and communication between the nervous and immune systems - Nature Reviews Immunology

Here, Swirski and colleagues explore how the nervous and immune systems connect and collaborate to respond to internal and external stimuli. In particular, they consider how the exchange of informatio...

nature.com

See you at Italian Outdoor Festival this Sunday! Will speak with Dylan Liabeuf (berlin-barcelona.com) and ultrarunning legend Filippo Canetta about #immunology #running #exercise #Wellness #scicomm 🏠 @unisr.bsky.social, SR-Tiget, San Raffaele italianoutdoorfestival.com/event-item/a...

Allenare il sistema immunitario: la scienza dell'(ultra)running - Italian Outdoor Festival

Tutti sappiamo che l'esercizio fisico “fa bene”, ma in che modo, e perché? Come e fino a che punto possiamo allenare il nostro sistema immunitario? Ne discutono due scienziati-atleti (Renato Ostuni e ...

italianoutdoorfestival.com

Review @cp-trendsimmuno.bsky.social @ostunilab.bsky.social IL-1β+ macrophages and the control of pathogenic inflammation in cancer www.cell.com/trends/immun...

and here's the Sharelink with full access: authors.elsevier.com/a/1ks7s5Eb0R...

Renato Ostuni@ostunilab.bsky.social · last yr.

Happy to share our reflections @cp-trendsimmuno.bsky.social on our favourite cells: IL-1β+ macrophages 🔥🔥🔥 Molecular, spatial, temporal, functional properties in cancer and beyond... it's all in there from the awesome Nicoletta Caronni, Federica La Terza and @frosio.bsky.social tiny.cc/y94f001

IL-1β+ macrophages and the control of pathogenic inflammation in cancer #immunology

IL-1β+ macrophages and the control of pathogenic inflammation in cancer

While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated macrophages (TAMs). Among these, interleukin (IL)-1β+ TAMs – cells with high levels of expression of inflammatory response and tissue repair genes, but with limited capacity to stimulate cytotoxic immunity – are emerging as key drivers of pathogenic inflammation in cancer. In this review we discuss recent literature defining the phenotypical, molecular, and functional properties of IL-1β+ TAMs, as well as their temporal dynamics and spatial organization. Elucidating the biology of these cells across tumor initiation, progression, metastasis, and therapy could inform the design and interpretation of clinical trials targeting IL-1β and/or other inflammatory factors in cancer immunotherapy.

dlvr.it

#MustRead. For #TumorImminologyLovers & more, check this fantastic review @ostunilab.bsky.social &co @cp-trendsimmuno.bsky.social all about #IL1 from #macrophages & pathogenic #inflammation in #cancer. #ScienceMatters dlvr.it/TJslPb

IL-1β+ macrophages and the control of pathogenic inflammation in cancer

While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated mac...

dlvr.it

Happy to share our reflections @cp-trendsimmuno.bsky.social on our favourite cells: IL-1β+ macrophages 🔥🔥🔥 Molecular, spatial, temporal, functional properties in cancer and beyond... it's all in there from the awesome Nicoletta Caronni, Federica La Terza and @frosio.bsky.social tiny.cc/y94f001

IL-1β+ macrophages and the control of pathogenic inflammation in cancer

While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated mac...

tiny.cc

chng.it/kK2HMP5pGk

Sign the Petition

Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

chng.it

More on the role of IL-1 inflammation in TME... Deletion of TREM2 in pancreatic cancer unexpectedly accelerates disease progression due to secondary increase of pathogenic IL-1b+ TAMs 🔥🔥🔥 www.gastrojournal.org/article/S001...

Congrats to all award recipients from our meeting, T Cell Differentiation in Tissue Microenvironments/Innate Immune Memory! #KSTCells25 #KSInnateImmune25 @ostunilab.bsky.social @delgoffelab.bsky.social @thelundlab.bsky.social @drshrutinaik.bsky.social @labfairfax.bsky.social @ostunilab.bsky.social

Last week in Vancouver was wild—my first time overseas didn’t disappoint ❄️. Got chills sharing our work on IFN regulation and seeing it finally go international 🦠. So thankful to the organizers and to who is making the dream possible @ostunilab.bsky.social @keystonesymposia.bsky.social

Shout out to this group of inspiring scientists! One of the best keystones hands down. Wishing everyone safe travels back. So grateful for the scholarship and a chance to share my work.

We're in the endgame now with Dr. Maz Divangahi wrapping up amazing joint 3d memory meeting #KSinnateimmune25 #KSTcells25. Thx to the organizers @drshrutinaik.bsky.social @labfairfax.bsky.social @ostunilab.bsky.social @nikjoshilabyale.bsky.social @thelundlab.bsky.social @delgoffelab.bsky.social 👏👏

Amazing kickoff by Yasmine Belkaid keynote on the role of immunity in pregnancy and lactation @keystonesymposia.bsky.social #KSinnateimmune25

And here is a pretty picture of a dendritic cell to get us started 😀.

Happy New Year! I am a newly-arrived refugee from the other platform. Looking forward to (re-)connecting with friends and colleagues in this community!

The science of pasta cacio e pepe 🇮🇹👨‍🍳

Giacomo Bartolucci (he)@gbart.bsky.social · 2y ago

1/n Some time ago my colleague, excellent cook, and friend Ivan told me: "Cacio e pepe is the recipe that I screw up more often. Let's make a project studying systematically the physics of that sauce". Prepare to get cheesy, I'm glad to share the Cacio e paper preprint: arxiv.org/abs/2501.00536

Catch @drshrutinaik.bsky.social, @labfairfax.bsky.social, @ostunilab.bsky.social and Yasmine Belkaid for Innate Immune Memory. Submit your abstract for a poster presentation spot by Jan. 9th (11:59pm MST)! keysym.us/KSInnateImmu... #KSInnateImmune25 #keystoneconferences #innateimmunity

#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair

Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.

cell.com

Crazy hot stuff by Magali Irla @ciml.bsky.social - RANKL treatment reverts thymic involution and boosts T cell function in aged mice www.science.org/doi/10.1126/...

RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice

RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.

science.org

Coffee in Naples really is something else 💚

Fantastic study (and thread👇) by the awesome @obenaufa.bsky.social lab!!! Cancer cells shut down antigen cross-dressing and T cell activation via PGE2 @natureportfolio.bsky.social

Anna Obenauf@obenaufa.bsky.social · 2y ago

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

A grant reviewer praised our use of multi-comic* approaches and I think it's the best typo I've ever seen😍

Our very own Luca Frosio using Mr Bean to pitch his 🔥 discoveries on IFN regulation in macrophages - stay tuned!!!

IL-1 is SO RELEVANT in cancer 🔥 IL-1a released from dying tumor cells leads to myeloid cell recruitment and T cell suppression - targeting this pathway boosts efficacy of chemoTx and ICB Beautiful study by @ruffell-lab.bsky.social lab n Cancer Cell www.cell.com/cancer-cell/...

Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity

Hänggi et al. investigate how tumor necroptosis regulates anti-tumor immunity and find an unexpected role for interleukin-1α (IL-1α) release by dying cells in promoting tumor growth by driving recruit...

cell.com

With the deluge of new friends - if you are or know someone who is a looking for a position as computational scientist (any level) in #pancreaticcancer, #macrophages #spatialbiology #singlecell... we might have something for you. Will also consider wet lab ppl, send email if interested. pls repost!

Very excited to share our latest work on the uncoupling of epithelial regeneration and tumorigenesis in the gut! nature.com/articles/s41...

I go around saying that tissue repair and tumorigenesis are two faces of the same coin. @ejvillablanca.bsky.social &co now show that this is not always the case and the two processes can be "unlinked" in the gut! @natureportfolio.bsky.social www.nature.com/articles/s41...

Liver X receptor unlinks intestinal regeneration and tumorigenesis - Nature

Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.

nature.com

On the road again😎🎸 in Stockholm for the #Pancreatic #Cancer Congress at Karolinska - Swedish know how to spoil their speakers!

#LocationLocationLocation & #EveryCellIsAnImmuneCell!! Check out the final version just out today of our Trends in Immunology review on the regionalization of the immune response along the respiratory tract!! dlvr.it/TG3Qzc

Regional specialization within the mammalian respiratory immune system

The respiratory tract is exposed to infection from inhaled pathogens, including viruses, bacteria, and fungi. So far, a comprehensive assessment that integrates common and distinct aspects of the immu...

dlvr.it