Pacific Optica
@pacificoptica.bsky.social
Optics for multiphoton imaging, laser scanning, and more. Based in Santa Barbara, California. pacificoptica.com
Check out this compact 920 nm ultrafast fs laser for 2p imaging of GCaMP, etc.. Mounted on its side like this, it takes up very little space on the table. That's the Axon 920, generously loaned to the course thanks to @ewadorotaz.bsky.social and others at Coherent. It's what we use on our own rigs.
Che-Hang brought the Ventana, and @ianoldenburg.bsky.social brought the holography. All-optical 2p neurophysiology @cshlcourses.bsky.social A great collab. Summer courses are the best.
On Instagram now too... www.instagram.com/pacificoptica/ And LinkedIn... www.linkedin.com/posts/pacifi... Let's keep in touch.
The turnkey Ventana Wide 2-photon imaging system is in service at the CSHL Imaging course. Dr. Che-Hang Yu is happy to share its capabilities. @cshlcourses.bsky.social
Imaging fish at MBL. Field-of-view is 2 mm x 1 mm. 2048 x 1024 pixels. (submicron pixels) with the Ventana system -- the fastest imaging systems over large fields of view. pacificoptica.com/ventana/
We're at the MBL in Woods Hole, MA. Stop on by if you want to try it out for yourself. 2-photon imaging over a 3 mm x 3 mm field-of-view. The most compact mesoscale 2p also has the fastest scanning! pacificoptica.com/ventana/ pacificoptica.com/cousa/
FN > 45 Whatever objective you use, Ventana imaging systems will get more field-of-view out of it, with full NA, and diffraction limited. The best ever for multiphoton / two-photon. And fast! 16,000 - 24,000 lines/s across the full field of view. pacificoptica.com/ventana/
Cool paper from Garret Stuber's lab and colleagues, led by Madelyn Hjort. mPFC-VTA circuit for contingency degredation. doi.org/10.1038/s415... Fig. 3 & 4 used the Cousa objective: **2p imaging + 2p holographic optogenetic stim., deep in brain using microprisms** ! pacificoptica.com/cousa/
All Pacific Optica products are designed in Santa Barbara, California, USA.
Laser scanning on your equipment entails tradeoffs between speed, resolution, and field-of-view. Pick 2 of those 3. Now you can get all 3, with this breakthrough. www.laserfocusworld.com/optics/artic... Thanks @laserfocusworld.bsky.social
Huge field-of-view, fast, high res. two-photon imaging. This technology (paper link below) is available now, in the Ventana products. Sold as complete turnkey systems, or components. pacificoptica.com/ventana/ Installations are happening now at some of the best labs in the world.
Spencer LaVere Smith@spencerlaveresmith.bsky.social · 5mo agoTwo-photon calcium imaging at 24,000 lines/s, with the resonant axis spanning 4x what other systems can do. Inertia-free. Diffraction-limited. No tradeoffs. Che-Hang Yu developed a 4x angle multiplier for laser scanning. His paper is out today: opg.optica.org/optica/fullt... 1/n #fluorescenceFriday
An excited customer, sharing photos of the optics they just received. And one of the first Avocado objectives in customer hands. It's a Cousa-class objective, with an NA of 0.6 and a WD of 10 mm, optimized for 2p, and excellent performance out to the edges of the field-of-view. More info soon!
Loving the "CEO eats his own burger/hot dog/..." stuff. Pacific Optica's CEO uses his own Ventana, Diesel2p, and Cousa products. They're the high throughput, turnkey, workhorse systems that power the lab. pacificoptica.com/ventana/ pacificoptica.com/diesel2p/ pacificoptica.com/cousa/
“Because [science] is the most effective way of learning about the physical world, it erodes superstition, ignorance and prejudice, which have been at the root of the denial of human rights throughout history…” -Baron Taverne
![Photo of Eccles. “Because [science] is the most effective way of learning about the physical world, it erodes superstition, ignorance and prejudice, which have been at the root of the denial of human rights throughout history…” -Baron Taverne](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:hsfslhusossxicx3snaxbezv/bafkreid47azwdao452xqix442agjjgm4vltxgcaogvqez7wiuu6bhdjhcm)
“Because scientific knowledge is tentative and provisional, it is the enemy of dogma.” -Baron Taverne
“Because science rejects claims to truth based on authority and depends on the criticism of established ideas, it is the enemy of autocracy.” -Baron Taverne
In 2025, we unlocked new frontiers in multiphoton optics and imaging. In 2026, you can get the best 2p systems you’ve ever seen. Accelerating your work. Higher throughput. Easy to use. Focus on your neuro work, and leave the 2p to PacOp.
Check out some sweet Ventana Wide + Cousa imaging. pacificoptica.com/ventana/ Live raw data over a 3.2 mm wide field-of-view with 16,000 lines/s scanning and submicron resolution. Demo now at @omibs-mbl.bsky.social Thx @ewadorotaz.bsky.social @mbfbioscience.bsky.social @crisrodtsou.bsky.social !
Scientists explore, measure, gather evidence, figure things out, and share openly. Their work benefits us all. Demo imaging at MBL/Woods Hole and CSHL this summer. Explore further. pacificoptica.com
Put whatever objective you want on the Ventana Wide. It will give you the largest field of view with high speed scanning: eg, 3.2mm x 3.2mm with a 10x. Fast, flexible 2p imaging. Che-Hang Yu is helping MBL courses with this Ventana Wide system pacificoptica.com/ventana/
Just landed in Woods Hole for summer courses: a Full Ventana Wide system. pacificoptica.com/ventana/ with a Cousa pacificoptica.com/cousa/ www.mbl.edu/education/ad... www.mbl.edu/education/ad... Thanks, Coherent! Thanks, MBF! Thanks to course leadership and MBL staff!
Widespread cortical representations of innate behaviors in the mouse. www.biorxiv.org/content/10.1... Using the Diesel2p pacificoptica.com/diesel2p/, they found that "more directed and unilateral grooming movements had greater cortical associated responses than more stereotyped bilateral movements"
吉祥寺 日曜日。2-photon, optics, 生ビルと TexMex 食べ物。 maps.app.goo.gl/xoRrGNX7xvK1... ふるってご参加ください。
maps.app.goo.gl
No more stitching artifacts. Just image the whole field-of-view, at high resolution, in one pass. The Ventana systems give submicron resolution over huge fields-of-view almost 10 square mm. At high speed. Cover a 3.2 mm x 3.2 mm area in 4k resolution in 0.26 s. pacificoptica.com/ventana/
Cool!! This is an exciting new Neuro AI #NeurIPS competition. By the way, the large scale 2p data for this NeurIPS competition was taken with a Diesel2p system. pacificoptica.com/diesel2p/
Diesel2p - Pacific Optica
pacificoptica.com
Spencer LaVere Smith@spencerlaveresmith.bsky.social · last yr.Can your AI beat a mouse? Mice still outperform our best computing machines in some ways. One way is robust visual processing. 10 years ago I decided to work on HARD behavior driven by COMPLEX visual processing. And that risk is paying off now. #neuroAI 1/n
🌌 Curious how visionary engineering shaped one of humanity’s greatest scientific instruments? Discover the architectural origins of the JWST in this in-depth #SPIE_JATIS article: www.spiedigitallibra...
