In honor to people who died in the terror. 25 years…

📣 Our abstract, “Enhanced High-Speed In Vivo Voltage Imaging Through Engineered Two-Photon Excitation,” was selected for #SfN26 NANO44 symposium: Imaging and Recording Neural Activity. Nov. 18, 2026 | 8:00–11:30 AM Abstract #4797 Thank you to my industrial team and academic collaborators! 🙌

Oh wow! @thetransmitter.bsky.social amplified recent Bsky chatter about the dire US grant landscape. Thank you, @emilysingerneuro.bsky.social 🙏.

The Transmitter @thetransmitter.bsky.social · 2mo ago

Two years into one of the most tumultuous tenures in U.S. federal funding, researchers outline how they are coping with ongoing changes and reflect on the impact these changes are having on the system more broadly. By @emilysingerneuro.bsky.social www.thetransmitter.org/funding/amid...

Interesting work from the lab of Na Ji on how axial imaging resolution (3.5- 20 um) affects the extraction of accurate neuronal signals. Very instructive! www.biorxiv.org/content/10.6...

High Axial Resolution Is Necessary for Quantitative Two-Photon Calcium Imaging of Neuronal Populations

Two-photon calcium imaging is a standard tool for measuring neuronal population activity in vivo , yet how axial resolution, sensor expression strategy, and analysis pipeline jointly affect data accur...

biorxiv.org

(1-3) In recent bioRxiv article from Cristina Rodriguez's lab @Yale the authors measured both GDD and third-order dispersion (TOD) directly at the objective focal plane at 1300 and 1600 nm. #3P #multiphoton biorxiv.org/content/10.6...

Attended, made many new friends, learned new things… quantum physics is applicable! Thanks to the organizers for a great time. quantum.utdallas.edu/tqs2026/

I hope you’ll have a chance one day to see the images captured with Ventana. Also offered with its holographic optogenetics option and supported with Monaco laser. Ventana truly offers a window into the brain at scale! And the brilliant people behind it are another reason why it is so special. 🚀🧠🥳🤓

Pacific Optica@pacificoptica.bsky.social · 3mo ago

Check out this compact 920 nm ultrafast fs laser for 2p imaging of GCaMP, etc.. Mounted on its side like this, it takes up very little space on the table. That's the Axon 920, generously loaned to the course thanks to @ewadorotaz.bsky.social and others at Coherent. It's what we use on our own rigs.

Glad I took this selfie before poster session opened this morning. It started at 9 and then it was 1 pm quickly. I did not drink, I did not eat. Thank you all who stopped by my poster at #FENS2026. I loved to talk to you all about lasers. Happy imaging.

Very interesting session this morning at #fens2026 on All-optical voltage imaging for neuronal circuits dissection. Few questions - how much more improvement can come from optimizing excitation source vs engineering better sensors? Are newer GEVIs shifting 2p excitation away from 920-940 nm range?

At #fens2026 and available to brainstorm with you how to improve two-photon image quality for fast imaging with photons craving fluorescent probes. Send me a msg and let’s chat indoors over iced coffee! Outdoor temp reached 37 C! 🫠

Excited to share our first lab preprint! We enabled fast wide-field FLIM with low noise and high dynamic range. We built compact resonant modules for EO-FLIM that fit into your hand and developed methods to capture multi-exponential phasor plots at up to 500 Hz. www.biorxiv.org/content/10.6...

Great few days at @mblscience.bsky.social supporting Neurobiology and NSB courses. It’s always exciting to see how ultrafast laser technology help enable new #neuroscience imaging methods. A big thank you to organizers, instructors, students, Coherent and others for making this event spectacular.

I’m going to spend a couple of days this week at @mblscience.bsky.social. Cool place, cool people and great science.

If you're not replacing your PMTs every 6 months, you might as well opt for SiPMs. src: www.nature.com/articles/s41... sipm: opg.optica.org/oe/fulltext.... www.nature.com/articles/s41...

With #FENS2026 just around the corner, our unofficial @fens.org abstract explorer is back: fens2026.neuronaldynamics.eu • Search abstracts by author, keyword, affiliation, and more • Discover related work using abstract similarity • Save favorites, add notes and tags, and build your own itinerary

Heading to Barcelona for my very first FENS! 🧠✨ Excited for the symposia, nerding out at posters, and presenting mine (PS07-10AM-005, Advanced Two-Photon Imaging Techniques, come say hi!). Also accepting applications for churros con chocolate buddies :) #FENS2026

Here’s our latest preprint on uncovering neural control of a coordinated walking pattern! doi.org/10.64898/202... (author-list jumbled, see pdf for corrected). Video shows the central paradigm in this study, we optogenetically induce walking in headless flies and sequentially reduce proprioception.

Back from #OpticaBiophotonics26. I had an opportunity to share how we think about lasers and our laser solutions for emerging imaging applications.

Multimodal alignments of in vivo imaging and spatial biology datasets at cellular resolution #mini2p #Axon920 #laser www.biorxiv.org/content/10.6...

PinkyCaMP is finally published!! My first paper co-first authored with @sikmys.bsky.social where we make a great optogenetic and multiplex compatible red calcium indicator. Thank you to @massecklab.bsky.social and @campbell-lab.bsky.social for guiding this journey www.nature.com/articles/s41...

PinkyCaMP: an mScarlet-based calcium sensor with enhanced brightness, photostability and multiplexing capabilities - Nature Methods

PinkyCaMP is a red genetically encoded calcium indicator with improved brightness and photostability. Derived from mScarlet, it does not exhibit photoswitching upon blue light illumination and is ther...

nature.com

Open-source modular FPGA system for two-photon mesoscope: multiarea, multidepth neural activity recording. @riichirohira.bsky.social et al. present high throughput 2p calcium and what is maybe the largest field-of-view 2p fluorescence lifetime imaging (FLIM) data. doi.org/10.1117/1.NP...

I spent a bit more time thinking about this pre-print biorxiv.org/content/10.6... 👉3P isn't about more laser power. It's about the right rep rate, one pulse per pixel, and laser stability. If you are not measuring pulse-to-pulse noise you're not measuring your biology.

Practical optimization for three-photon microscopy to allow larger field of view and faster calcium imaging (10-30 Hz) www.biorxiv.org/content/10.6...

Easter time with my husband while our daughter is studying in PA

Back from #FOM2026. In multiphoton microscopy space label-free imaging, and spectroscopy in structural and metabolism biological imaging stood out. I’m excited to grow and support this space too.

*First preprint from our lab* !!!!! How does the brain learn to anchor its internal sense of direction to the outside world? 🧭 led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman: “Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6... Thread ⬇️

The most sensitive green and red #norepinephrine #sensors engineered to date are out in #naturemethods! Deeply grateful to all our funders and contributors who made this work possible. A true team effort. @erc.europa.eu @snsf.ch doi.org/10.1038/s415...

Next-generation multicolor indicators for in vivo imaging of norepinephrine - Nature Methods

Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...

doi.org

We are finally online 🥳 What a fantastic adventure with @rrsims, the @emilianilab.bsky.social and all co-authors from IdV Paris #TwoPhoton #Voltagers #Holography #Rhodopsins

Neuron@cp-neuron.bsky.social · 8mo ago

😎I'm delighted to announce that Coherent Corp. will be exhibiting at Sunposium Conference (mpfi.org/events/sunpo...) on Mar 09 - 11, 2026 in West Palm Beach. 🤩Attend my presentation Monday, March 10, board #101. 🤝Schedule a 1-1 with me to talk about your next microscopy projects. #neuroscience