🔬 Featured in AJT’s August issue! “Donor-reactive clonotypes are overrepresented in the urinary T-cell repertoire during kidney transplant rejection and show distinct dynamics in the circulation,” by Aschauer et al. doi.org/10.1016/j.aj... #KidneyTransplantation #TransplantRejection #TCells

🥳 I am happy to share our latest manuscript published in @natcellbio.nature.com We use #Gastruloids to study #CellCompetition during early mammalian development and find not only that this is highly pronounced in our system but also tightly restricted in time. (1/12) www.nature.com/articles/s41...

Mosaic gastruloids reveal a temporal restriction for developmental cell competition - Nature Cell Biology

Frenster et al. utilize mosaic mouse gastruloids as a model of cell fitness and competition, identifying a temporal window between primed pluripotency and early gastrulation during which cell competit...

nature.com

Insights from derivation of human IPS #stemcell derived islet-like or off-target enterochromaffin (EC)-like cells in the pancreas #diabetes www.nature.com/articles/s41...

Excited to share our new paper in Nat Comms on how human stem cell-derived pancreatic progenitors choose between islet and enterochromaffin (EC)-like fates - and how we can steer that choice! A story in a few tweets… Full paper 👉 doi.org/10.1038/s414...

Hot off the press! This paper provides protocols for directed differentiation of hPSCs to different pancreatic islet-like endocrine cells as well as to enterochromaffin cells. Congratulations to the whole team! www.nature.com/articles/s41...

(🧵10/18) Works from Feb+March 2026🍀. From Dr. M. Cristina Nostro: “Efficient control of enterochromaffin versus islet differentiation from human pluripotent stem cell-derived pancreatic progenitors” PMID 41851084 www.nature.com/articles/s41...

So excited to hear about Hypoimmune islet transplants from Sonja Schrepfer from Sana Biotechnology - without immunosuppression Is this the future for cell therapy in diabetes? @albertadiabetes.bsky.social celebrating the 25th anniversary of the Edmonton Protocol #25EP

Some chapters are harder to get out that others. This was like birthing an elephant. But it's great. Channel your enthusiasm: Chapter 19 part 1, Metabolic Acidosis www.rosebook.club/episodes/202...

Chapter Nineteen, Part 1: Metabolic Acidosis, The Show — Channel Your Enthusiasm

Chapter 19: Metabolic Acidosis. Part One, The Show

rosebook.club

Pretty exciting! I wonder how long the effect will last…

American Journal of Transplantation@amjtransplant.bsky.social · last yr.

Article In Press! Can gene therapy help prevent rejection? AAV-mediated PD-L1 delivery during cold storage was associated with reduced acute rejection in a rat lung transplant model. www.amjtransplant.org/article/S160...

Article In Press! Can gene therapy help prevent rejection? AAV-mediated PD-L1 delivery during cold storage was associated with reduced acute rejection in a rat lung transplant model. www.amjtransplant.org/article/S160...

Adeno-Associated Virus-Mediated Transduction of PD-L1 in a Rodent Lung Transplant Model

Acute cellular rejection (ACR) is a key contributor to chronic lung allograft dysfunction (CLAD) following transplantation; while treatable, traditional immunosuppressive (IS) therapies are associated...

amjtransplant.org

Well done! Congrats from the east 😎

Francis Lynn 🇨🇦@nictitate.bsky.social · last yr.

Promoted! This one's for you Dad, miss you. A huge thanks to all my wonderful and supportive colleagues, some anonymous, that helped with this!

🧬 Excited to share our latest study now In Press: In this study led by rising star @sarahcolpitts.bsky.social, we show that IL-10⁺ #ILC2s prevent rejection and improve islet graft survival and function in humanized mouse models. Read more: doi.org/10.1016/j.aj... #Immunology #ImmunoSky #CellTherapy

Interesting anecdote when a patient shows up with a ChatGPT differential diagnoses list 😏 www.ajkd.org/article/S027... @ajkd.bsky.social

Adapting to Artificial Intelligence in Nephrology Practice

I am an academic nephrologist practicing for more than 10 years in a tertiary medical center. A 55-year-old man presented to my clinic with concerns about poor appetite and abnormal kidney function pe...

ajkd.org

A greater understanding of hypoxia’s impact on stem cell-derived #islets offering a potential intervention for clinical applications #T1D @natcomms.nature.com www.nature.com/articles/s41...

Improving cellular fitness of human stem cell-derived islets under hypoxia - Nature Communications

Hypoxia impairs the efficacy of stem cell-derived islet cell therapy, making it a potential barrier for treatment of type 1 diabetes. Wang et al. identify EDN3 as a key factor that preserves β cell id...

nature.com

📢 Register now! Annual Transplant Research and Education Conference 📅Thurs June 5, 2025 - Fri June 6, 2025 📍Toronto (Virtual option available) More details and to register: bit.ly/ATCEduResDay @uhn.ca @uhnresearch.ca @uoftmedicine.bsky.social #education #transplant #research

Recording up on our channel now youtu.be/e85gl9RydBM #NephGR #NephSky

Precision Diagnostics and Discovery for Diabetic Kidney Disease with Dr Justin Chun

YouTube video by Ottawa Nephrology

youtu.be

Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · last yr.

Happening this Thursday #NephGR at Ottawa on Precision Diagnostics in Diabetic Kidney Disease with Dr Justin Chun from @ucalgary.bsky.social @ucalgarymed.bsky.social

Excited to enroll our first participant for testing an agent (tolimidone) we hope will promote beta cell regeneration, building on preclinical work from Dr Jean Buteau at @albertadiabetes.bsky.social. Supported by Alberta Diabetes Foundation & biodexa pharmaceuticals www.ualberta.ca/en/folio/202...

Could a pill cure diabetes? A U of A researcher is working on it

A simple pill to treat or even cure diabetes could be possible, thanks to University of Alberta research — and funding that is laying vital groundwork.

ualberta.ca

Although a lot of work still to do, a great step forward for pluripotent stem cell-based therapies for kidney disease!

Harnessing Pluripotency@pluripotency.bsky.social · last yr.

📣 NEW PAPER ALERT! 🧵 I love kidney organoids - tiny nephron clusters grown in the lab from pluripotent stem cells. But can they treat kidney disease? New data suggests they can (in mice)! Let's dive in ⬇️ tinyurl.com/mr3sd6vu #KidneyOrganoids #CellTherapy #ChronicKidneyDisease #AcuteKidneyInjury