Paul A. Welling, MD
@pawellingmd.bsky.social
MD-Scientist Professor, Physiologist exploring molecular mechanisms of sodium-potassium balance, hypertension & kidney disease. Hobbies: Travel, Golf, Food, Wine & Spirits, Biking, O's fan Johns Hopkins School of Medicine
Our review sheds light on a hidden driver of hypertension: low dietary potassium & the kidney’s “potassium switch.” The switch regulates potassium balance with ancient, low-sodium diets; in today’s high-salt, low-potassium diet, it increases BP and cardiovascular risk www.nature.com/articles/s41...
The kidney distal tubule potassium switch, modern diet and hypertension - Nature Reviews Nephrology
This Review focuses on the potassium switch signalling pathway and its regulation of urinary sodium excretion according to plasma potassium levels. Welling and colleagues examine how this pathway affe...
nature.com
🚨APS has submitted formal comments to the Office of Management and Budget urging it to withdraw proposed sweeping changes to the federal research grant funding process. More on the full comments and how to make your voice heard: https://ow.ly/AG8C50ZlbSP #FightForPhysiology #SciPol #Advocacy 🧪
A 20 year study on 2 NIH diversity programs in Science Advances shows they doubled undergrads' odds of getting a Ph.D. That is, before the funding for those programs and for the study itself was terminated last year: www.statnews.com/2026/06/17/n...
NIH diversity programs doubled undergraduates’ odds of getting a Ph.D., 20-year study finds
A new study found that two diversity-oriented programs supported by the NIH doubled the odds that an undergraduate would earn a Ph.D.
statnews.com
@nejm.org addresses the OMB rule that can/will ruin the US scientific enterprise. Write your comments on the rule! www.federalregister.gov/documents/20...
The OMB and the Politicization of Science | NEJM
The Editors highlight three aspects of OMB’s recently proposed rule changes as particularly striking: that decisions on research funding would be made by political appointees, that funding could be...
nejm.org
Call for a paradigm shift in dietary management of hypertension and associated cardiovascular-kidney disease. New evidence supports broadening the current approach, which focuses solely on sodium reduction, to place equal emphasis on increasing potassium intake. www.sciencedirect.com/science/arti...
sciencedirect.com
The White House proposes sweeping changes to federal grant-making. APS Science Policy Director Rebecca Osthus discusses what’s at stake and how to make your voice be heard. Submit a comment by 7/13: https://ow.ly/bc7V50Z7kib #SciPol #Advocacy #FightForPhysiology 🧪
NIH to cap grants for well-funded investigators | Science www.science.org/doi/full/10....
NIH to cap grants for well-funded investigators
New system would limit researchers to the equivalent of three R01 grants.
science.org
This is a substantial power grab by OMB. Comment period starts tomorrow. Here are two relevant excerpts. 1/3
BREAKING: New proposed OMB regulation, applying to all federal grants, requiring grant reviews by senior political appointees and re-emphasizes that "peer review remains advisory and does not replace agency discretion". #standupforscience public-inspection.federalregister.gov/2026-10817.pdf
This is bad. Bad for researchers. Bad for science. Bad for universities. Bad for professional associations. For example: 1. Every award would be vetted by political appointees, who could overrule peer reviewers and deny the award if it doesn't advance the president's priorities. 1/🧵
Summary of Key Changes in OMB’s Proposed Federal Financial Assistance Rule. Russell Vought is going destroy American Science. elizabethginexi.substack.com/p/summary-of...
❓Did you know? #APS2027 will feature 80 Foundational Science Sessions submitted from APS members and our broader scientific community—will yours be one of them? We're accepting submissions now, but don't delay—the deadline is June 5: https://ow.ly/zz3n50YVjEL #WeArePhysiology #ProfDev
This could truly be a game changer for the millions suffering from chronic pain. Join us April 24 at #APS2026 to hear about emerging research on the pathophysiology of chronic pain and how it could unlock therapeutic breakthroughs: https://ow.ly/wZZb50YpOwf #ChronicPain #WeArePhysiology 🧪
The Physiological Challenge of Climate Change for Free-Living Terrestrial Mammals - www.annualreviews.org/content/jour...
The Physiological Challenge of Climate Change for Free-Living Terrestrial Mammals
Most scenarios that seek to predict the responses of terrestrial mammals to climate change focus on the direct thermal effects of higher ambient temperatures. Measurements from free-living mammals rev...
annualreviews.org
Are you a physician-scientist in training? Are you looking to connect with other trainees? We are proud to help sponsor two upcoming APSA Regional meetings: the South and Mid-Atlantic Regional meetings. 🧪 Find your meeting: https://www.physicianscientists.org/page/RegionalList
Early-Stage Investigator (ESIs) Resource Showcase Travel Awards to support ESI participation and attendance at the inaugural George M. O’Brien Kidney Resource Alliance (OKRA) Resource Showcase. To apply, complete the online application (okra.awardsplatform.com) by 022326.
okra.awardsplatform.com
journals.physiology.org/doi/full/10....
The response to kidney injury is epigenetically regulated through the activation of bivalent genes | American Journal of Physiology-Renal Physiology | American Physiological Society
Epigenetic regulation through histone modifications plays a crucial role in driving cellular state transitions. Regulating gene transcription through bivalency, the co-occurrence of activating histone...
journals.physiology.org
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good. Stay free
Bruce Springsteen - Streets Of Minneapolis (Official Audio)
YouTube video by Bruce Springsteen
youtu.be
Have you checked out the latest #KPMP publication in @kidneymed.bsky.social? If not, what are you waiting for? Dive in today! www.kidneymedicinejournal.org/article/S259...
Case Series of Histopathological Findings in Chronic Kidney Disease: Insights From the Kidney Precision Medicine Project
The Kidney Precision Medicine Project is obtaining kidney biopsies from people with chronic kidney disease (CKD) and acute kidney injury for comprehensive clinical, histopathological, and molecular ch...
kidneymedicinejournal.org
I spent the morning at the San Antonio immigration court. It’s out of control. Crawling with ICE - arresting legal immigrants showing up for court appearances. I asked one officer who they are prioritizing. His answer: everyone. I need to share with you what I saw.
Review article by Yuuta Imoto and Shigeki Watanabe "Beyond Clathrin: Decoding the Mechanism of Ultrafast Endocytosis" 🖱️https://ow.ly/evL150XY7S2 #UltrafastEndocytosis
Powerful piece in STAT this morning from some NIH staff members who have resigned www.statnews.com/2026/01/10/n... 1/3
The NIH has lost its scientific integrity. So we left
“We can no longer lend our credibility to an organization that has lost its integrity,” write four scientists and administrators who recently resigned from the NIH.
statnews.com
Here's a summary of all the data that supports adding more red meat to your diet
Remarkable: a treatment-induced increase in plasma potassium levels led to a significantly lower risk of appropriate ICD therapy, unplanned hospitalization for arrhythmia or heart failure, or death from any cause than standard care.
In patients with cardiovascular disease and an implantable cardioverter–defibrillator, increasing potassium levels to the high-normal range reduced the risk of arrhythmia events, hospitalizations, and death. Full POTCAST trial results and Research Summary: nej.md/4oQtHTN #MedSky
From unraveling chronic pain to exploring the body's sensing system, #APS2026 game changers feature some of the biggest topics in the life sciences. Don't miss top scientists from around the world as they discuss these vital issues. More: https://ow.ly/Clpz50XSBG9 #WeArePhysiology 🧪
Did you miss the PKD RRC Monthly Scientific Roundtable for January 2026? No worries, the outstanding presentation by Vishal D. Patel, M.D., UTSWMC, is now available at www.pkd-rrc.org/pkd-rrc-mont... #endPKD #PolycysticKidneyDisease
🌟 Call for Applications for Editor-in-Chief of AJP-Heart and Circ 🌟 We're looking for an engaging and dynamic Editor who will be actively involved in shaping the strategic direction of the journal. To submit your application ➡️ https://ow.ly/AkAp50XC57C American Physiological Society
🌟 Call for Applications for Editor-in-Chief of Physiological Reviews🌟 We're looking for an engaging & dynamic Editor to actively commission Reviews from high impact authors across all areas of #physiology. https://ow.ly/2oSy50XC4Nb American Physiological Society