📢 A new episode is out! Brenda and Jason speak with Dr. Daniel Peeper (@peeperlab.bsky.social) at the Netherlands Cancer Institute about the use of function-based, #genome-wide screens to develop concepts for rational combinatorial #cancer treatment. 🎧 Listen now: https://bit.ly/3OVwMo6

We;re hiring Junior Group Leaders! 🔬✨ We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment. www.nki.nl/news-events/...

NEW Highlight of @nature.com paper by @peeperlab.bsky.social showing that T cell-containing heterotypic clusters can be isolated from clinical tumour samples, providing insights into phenotype and function #immunosky #cancersky

Cluster-derived, tumour-reactive T cells from clinical samples - Nature Reviews Immunology

A study in Nature reports that heterotypic T cell clusters identifed in clinical samples of melanoma metastases are biologically relevant to tumour control and might have therapeutic potential.

nature.com

Our new paper is out in Nature - online today! Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators. 📄 Open-access paper: www.nature.com/articles/s41...

Tumour-reactive heterotypic CD8 T cell clusters from clinical samples - Nature

Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.

nature.com

In a new Nature Genetics paper our researchers identified a synthetic lethal interaction in 50% of cancers. Tumors lacking CDS1 depend entirely on CDS2. Blocking CDS2 kills cancer cells while sparing healthy tissue ➡️ www.nki.nl/news-events/...

The SMR 2025 Annual Congress (Amsterdam Oct 25-28) covers basic, preclinical & translational melanoma research of international top investigators. It is a very enjoyable conference with top faculty and now improved with ample opportunity for young investigators to network. Join us! smrcongress.org

Society Melanoma Research Congress

smrcongress.org

Major congratulations to my PhD student Tim Arnoldus @nkinl.bsky.social @oncodeinstitute.bsky.social ‬on publishing his exciting discovery today in Nature Genetics! 🎉 By computational mining Tim found a synthetic lethal target that may impact future treatment of half of all cancers.👏 t.co/cQdeYQinsX

Congrats to Sofía Ibáñez Molero @NKI_nl and @oncodeinstitute for excellently defending her PhD thesis, on functional interactions between cancer and the immune system, with several interesting papers already published and under review. Great work Sofía and best of luck with your postdoc!

📢 Applications for the NKI PhD program now open till Feb 28. Several exciting positions available, including one in my lab on discovering new biology and therapeutic opportunities of a population of enriched tumor-reactive T cells we recently identified. www.nki.nl/careers-stud...

More knowledge about immunotherapy, advanced diagnostics, and reducing overtreatment. Thanks to financial support from KWF Dutch Cancer Society, 13 research teams from the Netherlands Cancer Institute are launching new projects ➡️ www.nki.nl/news-events/...

📢 Applications for the NKI PhD program open from Jan 1 - Feb 28. Join our international research community in Amsterdam, working in cancer biology, AI research & life sciences with leading scientists and top facilities #PhD #CancerResearch More info: bit.ly/3O4bOjq

My first post here: Congrats to David Vredevoogd from my lab @NKI_nl @oncodeinstitute + collaborators for reporting on TMED, a new regulator of both immune checkpoints PD-1 and CTLA-4, which is amenable to therapeutic intervention. Read the paper here jitc.bmj.com/content/12/1...