Peng Wu
@pengwu.bsky.social
Professor at Scripps Research. Interested in glycosylation, cancer immunology, and autoimmunity.
This is the first @smartsymposium.bsky.social , Decoding the Glycome. We have lined up fantastic speakers, including experts in glycosylation and tool developers whose technologies hold exciting potential for applications in glycoscience. We look forward to welcoming you to Shenzhen this November
会议预告 | SMART Symposium：解码糖组—探索生物学未达之境
2026年11月16日-19日召开会议，2026年11月13日报名截止
mp.weixin.qq.com
This is an excellent use of fucosylatransferase by Jie Li at Najing Univ. to construct platinum(IV)-antibody conjugates and induce MHC upregulation #glycotime academic.oup.com/nsr/advance-...
Uncoupling tumor immunogenicity from cell death with platinum(IV)-antibody conjugates
By uncoupling tumor immunogenicity from cell death, chemically well-defined platinum(IV)–antibody conjugates unlock strong synergy with anti-PD-1 and hig
academic.oup.com
#WeekendRead! #EveryCellIsAnImmuneCell! Vollmers Turley &co show @natimmunol.nature.com that lack of CSF1 in skin #fibroblasts decreases macrophage numbers dampening wound repair, and in turn boosts fibroblasts! In human #scleroderma the cellular circuit between fibroblasts & macrophages is altered!
Reciprocal regulation of fibroblast–macrophage equilibrium governs skin integrity - Nature Immunology
Turley, Buechler and colleagues show that dermatopontin-expressing fibroblasts provide CSF1 to form a supportive niche for skin-resident macrophages. This interaction is important for skin tissue arch...
nature.com
Learning a lot about bioorthogonal chemistry and clinical translation, great symposium organized by @pengwu.bsky.social and @siglecdude.bsky.social !
Pacifichem@pacifichem.bsky.social · 8mo ago“Hawaii doesn’t feel like anywhere else. It is so welcoming to everyone.” Thank you @carolynbertozzi.bskyverified.social l for joining us at #Pacifichem2025! Don’t miss her presentation this afternoon that is part of the Bio-Orthogonal Chemistry and Click Chemistry session.
This is absolutely the most significant glycobiology paper so far this year. Increasing cell surface N-glycosylation makes viable allo CAR-T cells without deleting the endogenous TCR #glycotime
Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy
SPPL3 deletion modifies glycosylation on primary T cells, reducing allogeneic immune responses without impairing tumor control by anti-CD19 allogeneic CAR-T cells. SPPL3-null, TCR-sufficient anti-CD19...
cell.com
I inherited a huge bottle of GDP-fucose from the Paulson lab today, thanks Jim! # glycotime
In this incredible work, @srouhanifard.bsky.social developed a new catalyst, which makes CuAAC truly biocompatible rdcu.be/enfHz
inCu-click: DNA-enhanced ligand enables live-cell, intracellular click chemistry reaction with copper catalyst
Nature Communications - Tracking biomolecules in living cells requires fast but gentle labeling. Here, authors introduce inCu-click, a DNA-conjugated ligand that localizes copper to enable...
rdcu.be
The Rabinovichlab discovered that MDSC-specific deletion of ST6Gal1 enhanced GAL1-driven suppressive signals and accelerated tumor growth, effects that can be ameliorated by GAL1-blocking antibodies www.cell.com/immunity/ful...
Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells
Blidner et al. identify a glycosylation-dependent, galectin-driven circuit as a common mechanism that simultaneously induces immunosuppressive and pro-angiogenic functions in myeloid-derived suppresso...
cell.com
Such an inspiring talk by Dr. Rabinovich #Glyco27 on the immuno-modulatory functions of galectins #immunotherapy
Congratulations to Ellie for successfully defending her Ph.D. Her thesis work provided new insights into the inhibitory interactions between sialoglycans and SIglecs #glycotime We are so proud of you!
“Given the very real consequences for our competitiveness, our standard of living and, yes, also our bottom lines, we all ought to be making the case for aggressively funding basic science.” www.nytimes.com/2025/04/28/o...
Opinion | The White House Tech Bros Owe Their Fortunes to the Research They’re Killing
Underlying many investments are breakthroughs in medicine and technology from great universities.
nytimes.com
#glycotime "OGT protects the genome against TET-mediated DNA demethylation and loss of heterochromatin integrity, preventing the aberrant increase in transposable element expression noted in cancer, autoimmune-inflammatory diseases, cellular senescence and aging" www.nature.com/articles/s41...
OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide - Nature Structural & Molecular Biology
Here the authors show that the disruption of OGT expression in mouse embryonic stem cells unleashes TET activity, causing genome-wide decreases in DNA methylation and increases in 5-hydroxymethylcytos...
nature.com
It’s nice meet to meet with @roviralab.bsky.social to discuss our fucosylation enzymes. Thank you for your kind host!
RoviraLab@roviralab.bsky.social · last yr.Thank you so much @pengwu.bsky.social for taking time to visit us at @ub.edu! We appreciate your insight and discussions on protein glycosylation mechanisms. @scripps.edu
Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs. Find out how your community may be impacted. Explore more at SCIMaP: scienceimpacts.org a 🧵
@rpdevrieslab.bsky.social fantastic work on the involvement of the LacNAc chains in human influenza A virus hemaglutinin receptor interactions #glycotime rdcu.be/dD4Q0
Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling
Nature Communications - Binding modes of antigenically drifted hemagglutinins of human influenza A viruses have been determined by NMR using synthetic N-glycans having 13C-labeled monosaccharides...
rdcu.be
Stromal cell sialylation suppresses NK cell function through Siglec-10 engagement #glycotime www.biorxiv.org/content/10.1...
Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis
The immunosuppressive tumour microenvironment (TME) reduces immune response effectiveness in stromal-rich tumours, including CMS4 colorectal cancer (CRC). Mesenchymal stromal cells (MSCs), precursors ...
biorxiv.org
Bad news — the effective freeze at the NIH’s Center for Scientific Review hits a major chemical biology study section. Not good. @jeremymberg.bsky.social
ChemKritzer@chemkritzer.bsky.social · 2y ago🚨 Chemical Biology & Probes study section (formerly SBCB, one of two NIH panels that reviews chemistry #chemsky 🧪) was abruptly POSTPONED w/no specific plans for rescheduling, less than 24h before start. If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩🔬
If our "academic leaders" are wondering what a real leader looks like, look no further. Who will follow Dr. Varmus? www.nytimes.com/2025/02/14/o...
Opinion | American Science is Under Attack (Gift Article)
The Trump administration hobbles research and endangers the public health.
nytimes.com
Look forward to speak at the 2025 Carbohydrate GRC #glycotime
Jennifer Kohler@doctorjj.bsky.social · 2y agoRegistration is open for the 2025 Gordon Research Conference on Carbohydrates and the associated Gordon Research Seminar! 🧪 We have a exciting line-up of confirmed speakers and more to be added! www.grc.org/carbohydrate... The conference will be held June 15 - 20 in Holderness, NH.
Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures. www.washingtonpost.com/health/2025/...
NIH cuts billions of dollars in biomedical funding, effective immediately
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
washingtonpost.com
Enhancing glycosylation levels is good for CAR-T, maintaining their anti-tumor efficacy without causing GvHD #glycotime
Changes in Glycosylation on the Cell Surface Result in Highly Potent and Long-Lasting Allogeneic CAR-T Therapy in Patients
Disclosures. No relevant conflicts of interest to declare.
ashpublications.org
Siglec binding to sulfated glycan @siglecdude.bsky.social #glycotine. Thanks for including us in this fantastic work.
Matthew Macauley@siglecdude.bsky.social · 2y agoOur latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab. pubs.acs.org/doi/10.1021/...