Pierre Apostolides
@pfapostolides.bsky.social
Cellular physiologist LARPing as a systems neuroscientist. Enthusiastic about new age music, fine scale model building (mostly styrene, sometimes computational), and non-linear processes in biological networks. www.apostolideslab.org
My dept. posted this on the other site and it’s not getting any ♥️, so I’m posting it here 🦋 Excited to work with lead PI Artur Indzhykulian (Harvard/MEE) and co-I Marcos Sotomayor (University of Chicago) on this important study & grateful to the Ushers Syndrome Society @washumedicine.bsky.social
We're hiring a research technicians to work a new NIH-funded project on the emergence of hearing after cochlear gene therapy in congenital deafness. Come join us! massgeneralbrigham.wd1.myworkdayjobs.com/MGBExternal/...
New paper: Spinal circuitry modeled for locomotion using spatial transcriptomics and cell-type projections. Local excitation, long-range inhibition, and a longitudinal skew—an asymmetric "Mexican hat"—give rhythm, rotational dynamics, and gait, with no pacemakers. www.nature.com/articles/s41...
Wait, so the modern world cares about supervised learning? Turns out the cerebellum field was onto something all these years
Jianing’s got a good point here. We should also think about the ethological validity of experimenter vs subject trial initiation. Are we modeling flashcard performance or world-exploration?
There should be more discussion of how behavioral trials are initiated in experimental design. Many experiments impose trial onset at random, but recent work by @davidrobbe.bsky.social suggests that self-initiated trial times in rats follow a long-tailed Wald distribution: 10.1101/2024.05.31.596850
We’ve all wanted to know the answer to this question for years. Congrats Aaron for figuring it out
Tuft dendrite spikes are accompanied by selective input from distinct functional networks https://www.biorxiv.org/content/10.64898/2026.06.10.731464v1
Yep.
Agentic coding is genuinely useful now, and there are some impressive reports of AI agents doing science. But how well and how reliably can they handle tasks scientists actually want to hand off, ones that bottleneck progress? How do we even measure that?? New paper🧵 arxiv.org/abs/2606.07718 1/10
Who was the A&R rep who decided Spasmolytic would be the single from Skinny Puppy’s seminal album Too Dark Park? Clearly this was the wrong call, Grave Wisdom is the superior song off the album. Ready to (amicably and non physically) fight anyone who says otherwise
LLMs are like any other machine, they’re either a benefit or a hazard. If they’re a benefit, that’s not my problem.
This is such an elegantly simple solution to ROI-specific photostim.
Our solution: instead of a complex/separate optical path, we route our ⚡ ️laser through the same resonant-scanning path as the imaging laser and simply turn it on/off over neurons/areas of interest. This allows for pixel-resolution accuracy, and ability to ⚡ ️anywhere in the FOV you can image. 3/n
Presynaptic GABAA Receptors Mediate Ethanol-Induced Suppression at a Central Auditory Synapse https://www.biorxiv.org/content/10.64898/2026.05.07.723441v1
"Researchers with Oregon Health & Science University [Laurence Trussell, former grantee] and Anhui University in China found in a mouse model that elevated levels of the neurotransmitter serotonin in the brain also resulted in elevated behavioral symptoms of tinnitus." news.ohsu.edu/2026/04/20/r...
Research links tinnitus with serotonin
Neurotransmitter known for relieving depression could have opposite effect on tinnitus.
news.ohsu.edu
Congrats Ruth Anne!!
"Ruth Anne Eatock PhD will receive the Bellucci Pioneer Award for her research and mentorship of young scientists" 👏 former HHF board member! Reg for the Bellucci Symposium, organized by another fmr bd member Peter Steyger PhD (in pic) May 22 in person + online: www.creighton.edu/medicine/dep...
New paper (with lots of cute animal videos!) Ever watch your dog "run" while asleep and wonder what’s going on in their brain? In Current Bio we suggest that those twitches aren't just leaky dreams—they’re a vital maintenance system for the most precise movements www.cell.com/current-biol...
REM-sleep twitching in adults and the maintenance of specialized sensorimotor systems
Blumberg et al. present video evidence of twitching during adult sleep in a diverse sample of animals. Adult twitching appears to selectively involve appendages used for active sensing, mirroring thei...
cell.com
Staff and administrators saw one final year of pay raises exceeding inflation this year, but that won't happen again for a while. Tenure-line faculty have had raises below inflation every year for the past decade. Tenure and promotion boosts are often modest (3-10%), and only happen twice.
Workforce Pay Increases - CUPA-HR
This is the public version of this data. CUPA-HR is the most comprehensive, accurate, and up-to-date source of higher education workforce salary data, collected separately for administrators, faculty,...
cupahr.org
David showed me some of these data about a year ago and all I could respond was “how does it feel to be right?” A milestone in the quest to find synapse-level explanations for brain function and behavior.
Synaptic dynamics as a tunable substrate shaping neuronal activity sequences https://www.biorxiv.org/content/10.64898/2026.03.22.713064v1
🎻✨ Excited to share my journey from music to auditory research at "Beer, Brain, and Arts!" during Brain Awareness Week. Join us tomorrow at the @hetnatuurhistrdam.bsky.social, or a lab tour at Erasmus MC @erasmusmc.bsky.social ! 🔗 www.brain-awareness-week-euc.nl #BrainAwarenessWeek #Neuroscience
Excited to share some new work from my lab, where we rigorously characterize differences between L5 and L6b extratelencephalic neurons in the auditory cortex!
biorxiv.org
Philly has a Rocky statue, NOLA’s got one of Ignatius Reilly. Only fair Delta City honor a notorious fictional denizen as well. Very happy this statue finally found a home after years of deliberation.
NMDA receptor-dependent presynaptic homeostatic plasticity? https://www.biorxiv.org/content/10.64898/2026.02.28.708706v1
Thank you NIDCD for supporting our work on learning-related plasticity in mammalian sound localization circuits.
Call it #ExplainableAI or just making sense of complexity. We establish a direct link between DNNs fit to #AuditoryCortex and more intuitive subspace models from the 2000s. Congrats @jeremewingert.bsky.social @satyaparida.bsky.social & Sam Norman-Haignere! #NeuroAI #SensoryNeuroscience rdcu.be/e5gLY
🚀 New preprint from the lab! Our first foray into the subiculum uses in vivo whole-cell recordings to show that dendritic plateaus are a prominent, learning-dependent signaling mode of subicular neurons. Feedback is welcome! www.biorxiv.org/content/10.6...
biorxiv.org
Big if true. Anyone know if human learning curves are also (mostly) trial count independent? www.nature.com/articles/s41...
Duration between rewards controls the rate of behavioral and dopaminergic learning - Nature Neuroscience
Cue–reward learning rate scales proportionally with the time between rewards. Consequently, learning over a fixed duration is independent of the number of trials. This challenges trial-based dopamine ...
nature.com