Maria Geffen

@geffenlab.bsky.social

Brain scientist who studies how we hear and form memories of sounds 🧠 🧬🔬🧪; prof at Penn. Loves🧘‍♀️🚴‍♀️✈️🥐🧶📷⛷️🏔️. Mom to 👦👧👦🐈🐈. Lab: hosting.med.UPenn.edu/hearing

Our brain is constantly looking for patterns. When something unexpected happens, we notice it more in a predictable context, than in an unpredictable environment. Our study identifies how the auditory cortex amplifies responses to unexpected sounds in predictable contexts. doi.org/10.1523/jneu...

Two photon imagine was used to identify the neuronal circuit for amplify the responses to unexpected sounds in predictable contexts.

Really enjoyed a fantastic lineup of talks at our annual Graduate Certificate in Computational Neuroscience Symposium. From studying monkey behavior to identifying biomarkers of food-related preoccupied thoughts to optimal color transformation in color blindness. Love the energy!

Maria Geffen and Josh Gold with students from Penn Certificate in Computational Neuroscience program.

PSA: don’t self-censor your grants. Don’t use the AI tools or word/phrase alternative sheets you see out there. Here’s why: 1) These tools are almost certainly wrong bc the list keeps changing. There’s no way they can be up to date, POs can’t even stay up to date. 🧵1/2

My NIH update Let me start by saying again how glad I am that NIH is now posting these curves on the Reporter front page. It is satisfying that leading by example from outside has led to this change and (I hope) reflects a commitment for NIH_leadership™ to hold itself accountable for this. 1/6

A graph from the from page of the NIH Reporter website showing the number of extramural awards award by month for fiscal years 2022-2026. The curve for fiscal year 2026 lies below the other curves.

I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

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Applications to present in the Early Career Session for the E.A.R.S. seminar series now open! www.med.upenn.edu/pennhearing/... The Early Career Seminar will feature four presentations, selected by the EARS organizing committee from submissions. Deadline: March 31: forms.gle/ScNp8exjEQ3A... .

EARS Early Career seminar application

Thanks for your interest in participating in the EARS early career seminar on April 14, 2026 at 1 PM ET. Please complete this form to apply by March 31, 2026. Presentations will be 10 minutes long wit...

forms.gle

New paper from the Geffen and @labhaas.bsky.social Laboratories just published! We find that the enigmatic thalamic reticular nucleus exerts bi-directional cell-specific control over sound processing. The super-thin sheet of inhibitory neurons is rather mighty and highly computationally relevant!

PLOS Biology@plosbiology.org · 5mo ago

The medial geniculate body #MGB in the #auditory #thalamus is a key early node in sound processing. @geffenlab.bsky.social &co show in mice that two inhibitory neuron types have distinct connectivity & effects on sound processing. @plosbiology.org 🧪 plos.io/47twOtM

 Inhibitory neurons differentially control sound-evoked responses in the MGB. Left: diagram of the proposed circuit underlying our results. Boxes: summary of effects of optogenetic manipulation of SSTTRN (top) or PVTRN (bottom) inactivation on MGB firing and the circuitry and results of computational models that support a similar distribution of effects.

Really enjoyed hosting the Daedalus Quartet for our systems neuroscience class and doing a mini experiment with them. We tested whether the musicians’ brains synchronized differently while playing music under different conditions (e.g. playing with metronome, while marching or just playing).

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The deadline to apply for the Brain Prize Cajal summer course in Computational Neuroscience has been extended to March 9! We’re excited for you to join us in sunny Lisbon! Please do not hesitate to send in an application and learn about computational neuroscience! @gjorjulijana.bsky.social

Maria Geffen@geffenlab.bsky.social · 6mo ago

A special year for the Cajal Course in Computational Neuroscience: the BRAIN Prize winners Haim Sompolinsky and Larry Abbott will join us as keynote speakers. And we will bring you the same great roster of instructors as every year. Applications are now open! cajal-training.org/on-site/comp...

In Cambridge in the 1970s, my dad, Colin Blakemore, worked and lectured on sensitive periods of sensory development. In my Cambridge undergrad lectures on this topic, I show a clip from one of his TV shows, which describes sensitive periods for sound categorisation, and features Prof Janet Werker:

Question re new biosketch format on sciEnv: under the previous nih biosketch format, we could list 5 references under personal statement and then additional 4 references per contribution to science (up to 25 references total). It seems that now it’s down to 10 references total. Is that right?