Dino Sbardellati
@phagebeelicious.bsky.social
Graduate Student studying bees, phage, and microbial ecology. I like bioinformatics, food, and art. Vannette lab - UC Davis. Github: https://github.com/dsbard
🦠🧫🧪🔬🌍🐝 🧬🖥 Awesome work led by Malick Ndiaye on paired strain-level #microbe - #phage metagenomes of SINGLE #honeybee guts, revealing diversity correlations at genus level... #Microsky #host-microbe
Philipp Engel@pengellab.bsky.social · 9mo ago🐝🦠 New paper: rdcu.be/eOf7A Phages may drive microbial diversity, yet we often don’t even know how phages & bacteria correlate in nature. Our new study tackles this in the honeybee gut, thanks to the great work of PhD student @malickndiaye.bsky.social at @dmf-unil.bsky.social @fbm-unil.bsky.social
Happy to announce that our comparative metagenomic analysis of the gut microbiota of five honeybee species - spearheaded by @aiswarya.bsky.social - is finally published in a peer-reviewed journal! rdcu.be/eKMCs @fbm-unil.bsky.social @dmf-unil.bsky.social 🧵👇
Evolution of gut microbiota across honeybee species revealed by comparative metagenomics
Nature Communications - Here, the authors perform metagenomic analysis of honeybee gut microbes, uncovering many previously unidentified species and host specific differences in composition and...
rdcu.be
New Preprint out! In this short and sweet article, we showcase how management practices (antibiotic treatment) has impacted the AMR profiles associated with bee microbiomes. The take home? More management = more plasmid-borne resistance! doi.org/10.1101/2025... #microbiome 🧪 🐝
Bee Microbiomes Harbor Diverse Antimicrobial Resistance Genes on Plasmids
Antimicrobial resistance (AMR) is an emerging public health threat. In North America, tetracycline and macrolide antibiotics are often used to prevent or treat bacterial infections in honey bees. Prev...
doi.org
New paper alert! We suggest caution in the analyses of viral auxiliary metabolic genes and propose a new overarching term - 'auxiliary viral genes' (AVGs) to describe different types of such genes. @simrouxvirus.bsky.social #phagesky #Microsky www.nature.com/articles/s41...
A call for caution in the biological interpretation of viral auxiliary metabolic genes - Nature Microbiology
This Perspective discusses virus-encoded auxiliary metabolic genes and provides a framework for the biological interpretation of these genes.
nature.com
After many years in the making, here is our host range #phage paper with #ecology, #evolution and #biocontrol perspectives published in Molecular Ecology! @phimresearch.bsky.social @inrae-pv.bsky.social #PVBMT #JulianGarneau onlinelibrary.wiley.com/doi/10.1111/... These are our key findings:
A Phylogenetic Host‐Range Index Reveals Ecological Constraints in Phage Specialisation and Virulence
Phages are typically known for having a limited host range, targeting particular strains within a bacterial species, but accurately measuring their specificity remains challenging. Factors like the g...
onlinelibrary.wiley.com
Kicking off Sunday morning #ASMicrobe with an entire phage ecology session \o/ thanks to @cathyhernandez.bsky.social and @phagebeelicious.bsky.social . And first, @cynthiasilveira.bsky.social on phages and geochemistry 🤩
Here’s an out-of-this-world-themed bumble bee! 🐝 Vector art and a fun fact about bees by @daniellerutkowski.bsky.social , screen-printed as a sticker by @phagebeelicious.bsky.social. #SciComm #BeeArt #VectorArt #ScreenPrinting #Pollinators #SciArt #Bumblebee #InsectArt
Sunday Sketch: Bumble Bee
Some bumble bee species are able to inhabit extremely cold environments, with their distribution stretching far north into the Arctic Circle. Vector art and fact by Danielle Rutkowski, Bluesky @dan…
theethogram.com
Excited to be on the way to #ASMicrobe once more ! And if you want to know more about our work on CRISPRs, metagenomes, and phages, please come and chat and/or come see me tomorrow morning (9:15am in the EEB-IDS-202 session, which looks amazing overall !)
Going to ASM Microbe 2025? Check out the in-depth symposium "Phage Ecology: From Prophage Decision Making to Ecosystem Modulation" hosted by Dr. Hernandez (@cathyhernandez.bsky.social) and I! We have some really cool talks lined up. Hope to see you there! 🧪🦠🔬 #Phagesky #Microsky
Dive into our lab’s first peer-reviewed publication—co-led with our friends @benadler.bsky.social and Muntathar Al-Shimary from the @doudna lab! If you’ve already read the preprint, don’t miss the new updates: doi.org/10.1038/s415... @naturemicrobiol.bsky.social
CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d - Nature Microbiology
Leveraging RNA-targeting dCas13d enables selective interference with phage protein translation and facilitates measurement of phage gene fitness at a transcriptome-wide scale.
doi.org
Is it “winner-takes all” when the simplest living things compete? Check out my fresh publication on phage coexistence in Science and a thread below🧵 www.science.org/doi/10.1126/...
Diverse phage communities are maintained stably on a clonal bacterial host
Bacteriophages are the most abundant and phylogenetically diverse biological entities on Earth, yet the ecological mechanisms that sustain this extraordinary diversity remain unclear. In this study, w...
science.org
Get ready to dance, our paper – Phage DisCo: targeted discovery of bacteriophages by co-culture – has been pre-printed! 🪩 This has been a really fun project to work on with @sianowen.bsky.social, @baym.lol, @nquinoneso.bsky.social, and our two talented undergrads Kesther and Carmen!
bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 2y agoPhage DisCo: targeted discovery of bacteriophages by co-culture https://www.biorxiv.org/content/10.1101/2024.11.22.624878v1
I've been seeing lots of new faces on here so I am reposting one of my recent publications. Turns out commercially produced bumble bees have simplified phage communities compared to free foraging honey bees, and phage sampling method matters! doi.org/10.1186/s401... 🧪🦠🐝 #Phagesky #Microsky
Targeted viromes and total metagenomes capture distinct components of bee gut phage communities - Microbiome
Background Despite being among the most abundant biological entities on earth, bacteriophage (phage) remain an understudied component of host-associated systems. One limitation to studying host-associ...
doi.org
Finally got around to processing my first cryo-EM image! This tailed phage was isolated from the gut of a honey bee and targets Bifidobacterium. Not 100% sure what the other circular structure is. If you have any ideas, let me know! 🐝🦠🧪 #phagesky
Check out this new preprint about the microbiome of honey wasps! Featuring lab mate Lexie Martin! doi.org/10.1101/2024...
The gut microbiome of honey-producing wasps has converged on that of social bees
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
doi.org
Do you like bees? How about phage? Check out our new paper published in Microbiome! In this research we compare how phage communities differ between bumble bees and honey bees and how sampling method influences recovered viral communities. 🧪 doi.org/10.1186/s401...
Targeted viromes and total metagenomes capture distinct components of bee gut phage communities - Microbiome
Background Despite being among the most abundant biological entities on earth, bacteriophage (phage) remain an understudied component of host-associated systems. One limitation to studying host-associ...
doi.org
cryo-EM image of phage isolated from bee gut material! More images (and experiments!) coming soon 🐝🦠🧪
Hey science friends! Ever wonder what the phage community of bumble bees look like? Or how to best sample host-associated phage communities? Check out our new preprint! Turns out that the bumble bees we sampled hosted extraordinarily low diversity phage communities, relative to honey bees. 🐝🦠🧪
Targeted Viromes and Total Metagenomes Capture Distinct Components of Bee Gut Phage Communities
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
biorxiv.org