Antentor “AJ” Hinton Jr
@phdgprotein86.bsky.social
Assistant Professor, Molecular Physiology and Biophysics, Vanderbilt University The Hinton Lab utilizes SBF-SEM and FIB-SEM to investigate the molecular mechanisms that regulate molecule transfer and morphology changes between the Mito and ER
Grateful for an incredible time at #Cardiometabolism in Keystone 🇺🇸 Honored to present our work on DRP1, mitochondrial dynamics, lipid droplets & muscle oxygenation in PAD. @keystonesymposia.bsky.social @bwfund.bsky.social @chanzuckerberg.bsky.social @vanderbilt.edu @vubasicsciences.bsky.social
Another preprint is out from the Neal Lab! 🎉 Excited to share the first systematic side-by-side comparison of ERAD Derlin paralogs, revealing distinct cellular functions for Derlin-1, Derlin-2, and Derlin-3. www.biorxiv.org/content/10.6...
Although Derlins are core components of ERAD, their paralog-specific roles have remained unclear. By analyzing all three in the same cellular context, we uncover clear non-redundant functions at the cellular level.
We reveal Derlin-2 is dominant paralog for ER stress relief & loss of Derlin-2 and Derlin-3 disrupts mitochondrial homeostasis, including: • altered ER–mitochondria contact sites • impaired respiration • defective Ca²⁺ handling Linking ER protein quality control directly to mitochondrial function.
Mechanistically, we identify ORMDL3, a regulator of sphingolipid metabolism, as a Derlin-dependent ERAD substrate. Without Derlins → ORMDL3 accumulates and mislocalizes to ER–mitochondria contact sites, driving mitochondrial dysfunction.
Why does this matter? ORMDL3 is genetically linked to multiple diseases, including: asthma, inflammatory bowel disease, metabolic disease, and cancer. Our findings suggest ERAD safeguards cellular health by preventing pathological ORMDL3 accumulation.
Conceptually, this work expands ERAD beyond misfolded protein clearance. Instead, Derlin-mediated ERAD can act as a spatial and quantity control system that regulates functional ER proteins to preserve organelle communication.
Importantly, ORMDL3 is genetically linked to several major diseases, including asthma, inflammatory bowel disease, metabolic disorders, and cancer, highlighting the broader biomedical relevance of this work. This work wouldn't have been possible w/o massive tour de force effort across multiple labs!
Congrats to first-author and amazing postdoc from my lab @nicola-scott.bsky.social and special thanks to @phdgprotein86.bsky.social lab, @drohsopretty.bsky.social lab, Dr. Dhanendra Tomar lab, and Dr. Mark Phillips lab!
Grateful for an incredible time at #Cardiometabolism in Keystone 🇺🇸 Honored to present our work on DRP1, mitochondrial dynamics, lipid droplets & muscle oxygenation in PAD. @keystonesymposia.bsky.social @bwfund.bsky.social @chanzuckerberg.bsky.social @vanderbilt.edu @vubasicsciences.bsky.social
Mini golf with @phdgprotein86.bsky.social and Jeeyeon Cha's labs, followed by pizza! Great way to kick off the first lab outing of the year!
Grateful for an amazing year—mentorship, fellowship, and community. Seeing my mentor, Dr. Gayle Slaughter of BCM, at ABRCMS meant everything. Thankful for friends and colleagues who sharpen me. “Steel sharpens steel.” — Proverbs 27:17 ✨
Grateful for an amazing year—mentorship, fellowship, and community. Seeing my mentor, Dr. Gayle Slaughter of BCM, at ABRCMS meant everything. Thankful for friends and colleagues who sharpen me. “Steel sharpens steel.” — Proverbs 27:17 ✨
In the STEM Tea podcast, @phdgprotein86.bsky.social sits down with Lindsey Keith-Vincent, Associate Dean at Louisiana Tech University, to explore her unique model for supporting faculty, mentoring students and fostering a culture of authenticity >>> www.biotechniques.com/podcasts/ste... 🧪
STEM Tea | Humans first, professionals second
In this episode, AJ Hinton is joined by Lindsey Keith-Vincent, a first-generation college graduate who is passionate about STEM education.
biotechniques.com
New preprint: Collaborative Team Science effort: @drnathanasmith.bsky.social & @phdgprotein86.bsky.social #URochesterResearch #VanderbiltResearch www.biorxiv.org/content/10.6...
The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease
Mitochondrial contact site and cristae organizing system (MICOS) complexes are critical for maintaining the mitochrondrial architecture, cristae integrity, and organelle communication in neurons. MICO...
biorxiv.org
In this STEM Tea episode with @phdgprotein86.bsky.social and Corey Reynolds, learn about the crucial need for more Black scientists in every stage of the scientific process, from student labs to clinical trials >>> www.biotechniques.com/podcasts/ste... 🧪
STEM Tea | Working together for better science and better opportunities
In this episode of STEM Tea, Corey Reynolds discusses his journey from academia to industry and how he'd like to see Black science grow.
biotechniques.com
What role do HBCUs play in student success? In the latest STEM Tea podcast episode, @phdgprotein86.bsky.social is joined by Haysetta Shuler, an I-O psychology consultant and HBCU supporter. Learn more about creating effective mentorships >>> www.biotechniques.com/podcasts/ste... 🧪
STEM Tea | Strengthening HBCUs
In this episode, Haysetta Shuler shares strategies for mentoring, maximizing opportunities, and the vital role of HBCUs in student success.
biotechniques.com
In this STEM Tea podcast episode, @phdgprotein86.bsky.social and his guests discuss the importance of STEM education in K-12 schools and how these programs can support and expand students’ career prospects, sense of belonging and scientific exploration >>> www.biotechniques.com/podcasts/ste... 🧪
biotechniques.com
In the latest STEM Tea podcast episode, @phdgprotein86.bsky.social and @ulisesricoy.bsky.social discuss how intentional learning can shape scientific research as well as mentorship practices >>> www.biotechniques.com/podcasts/ste... 🧪
STEM Tea | Being visible as an act of service
STEM Tea | Ulises Ricoy discusses his experiences of working on academic recruitment and how learning can be found everywhere.
biotechniques.com
Surviving isn’t enough; underrepresented groups in academia need to thrive. In this STEM Tea episode, @phdgprotein86.bsky.social is joined by @brielleryan.bsky.social and @heydrdukes.bsky.social. Learn why visibility is sometimes the most important step >>> www.biotechniques.com/podcasts/ste... 🧪
STEM Tea | Founding Black in Neuro
Brielle Ferguson and Angeline Dukes discuss Black in Neuro, the power of visibility in representation and critical lessons about mentorship.
biotechniques.com
Had such a great conversation with @phdgprotein86.bsky.social. It's always great to go down memory lane with @heydrdukes.bsky.social to the early days of @blackinneuro.bsky.social, but listening back also gave me a much-needed reminder of the power of community, especially right now.
BioTechniques@biotechniques.bsky.social · last yr.Surviving isn’t enough; underrepresented groups in academia need to thrive. In this STEM Tea episode, @phdgprotein86.bsky.social is joined by @brielleryan.bsky.social and @heydrdukes.bsky.social. Learn why visibility is sometimes the most important step >>> www.biotechniques.com/podcasts/ste... 🧪
How do we build a more equitable STEM community? 💡 In the latest STEM Tea podcast episode, @phdgprotein86.bsky.social is joined by Alberto "Beto" Vasquez from @ucsandiego.bsky.social to discuss mentoring students from underserved communities >>> www.biotechniques.com/podcasts/ste... 🧪
biotechniques.com
What does it mean to ‘lift while you climb’? 🧗🏾♀️ In the latest STEM Tea podcast with @phdgprotein86.bsky.social, Clintoria Williams, co-founder of Black in Physiology, shares her insights on impactful mentorship and leading with your 'why'. Listen here >>> www.biotechniques.com/podcasts/ste... 🧪
STEM Tea | Impact and sustainability in mentorship
In this episode, Clintoria Williams shares her journey in mentorship, discusses balancing life and work, and highlights the mission of Black in Physiology.
biotechniques.com
Meet our 2024 cohort of Next Generation Leaders! For the next 3 years, they will network with other rising stars, participate in professional development, and share their ideas for future research directions.
Time to celebrate for Neal lab members and @bummpucsd.bsky.social! Everyone delivered amazing talks, workshops and poster presentations at @ascbiology.bsky.social 🎉🎉Until next year!
Every year I am reminded of how incredible the Cell Biology community is at ASCB.
Introducing Dr. @jonathanccc-chem.bsky.social, the first PhD from the Dassama Lab! I am very proud of the broad and deep undertakings that formed Jonathan's thesis! Some highlights are in the comments. Many congrats to the doc!!
@cbmoens.bsky.social Welcome! Follow lots of people --that's how this place works!
24 years later and still the annual ASCB meeting is some of the best science and best reunions of the year. @ascbiology.bsky.social @applewhitederek.bsky.social @omqu.bsky.social @klukasik.bsky.social @chrisho.bsky.social @channyskye.bsky.social
