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Philippa Borrill

@philippaborrill.bsky.social

Wheat geneticist and group leader at John Innes Centre. Interested in #micronutrients, #senescence, #polyploidy and #genomics. She/her. https://borrilllab.com/

31 Posts1015 Follower 337 Folgt

@charpentiermyriam.bsky.social · 6mo ago

My lab at the JIC is recruiting 3 PDRA: 🔹 Bioinformatics / AI 🔹 Molecular Biology / Genetics 🔹 Proteomics Programme funded by the Novo Nordisk Foundation. 📅 Closing date: 27 February Apply via JIC website: www.jic.ac.uk/vacancies/ Please share with outstanding candidates. 🙏

Postdoctoral Researcher (Charpentier Group) | John Innes Centre

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Charpentier Group at the John Innes Centre, working on cutting-edge science in the field of plant calcium signalling.

jic.ac.uk

John Innes Centre @johninnescentre.bsky.social · 10mo ago

Applications are now OPEN for the JIF Rotation PhD Programme This prestigious 4-year #PhD programme trains graduate students in Plant and Microbial Sciences at the JIC, @thesainsburylab.bsky.social and @earlhaminst.bsky.social. 🗓️ Closing date - 13 November 2025 www.jic.ac.uk/training-car...

Rotation biology PhDs | John Innes Centre

Prestigious studentships, for entry in October 2022, this multi-disciplinary PhD programme includes; plant science, microbiology, biological chemistry, applied mathematics…

jic.ac.uk

Philippa Borrill @philippaborrill.bsky.social · 10mo ago

Delighted to be selected for the Carlotta Award celebrating female wheat researchers 🎉 Thank you to the committee - it was lovely to meet you in Bari! I am sure this award will continue to promote women's contributions to wheat research under the stewardship of @wheatinitiative.bsky.social

John Innes Centre@johninnescentre.bsky.social · 10mo ago

NEWS - International award for group leader recognises excellence in wheat genetics and genomics Dr Philippa Borrill @philippaborrill.bsky.social recently visited Italy to accept the Carlotta Award at the International Conference ‘From Seed to Pasta V’. okt.to/pUTHXA

Philippa Borrill @philippaborrill.bsky.social · 10mo ago

The mystery of redundancy between homoeologs continues! Knocking out one homoeolog in wheat doesn't cause the other homoeologs to be upregulated... nph.onlinelibrary.wiley.com/doi/10.1111/... Great work led by @delfidorussen.bsky.social with @emilieknight.bsky.social @simmojsimmo.bsky.social

Philippa Borrill @philippaborrill.bsky.social · 10mo ago

We are looking for a postdoctoral researcher to join our team! They will work on homeolog-informed approaches to tackle cold tolerance in wheat @johninnescentre.bsky.social Please find out more and apply here: jobs.jic.ac.uk/Details.asp?... #plantsciences #plantscijobs

John Innes Centre

jobs.jic.ac.uk

Christine Faulkner @pdchristine.bsky.social · last yr.

Exciting times to be at @johninnescentre.bsky.social ! www.jic.ac.uk/press-releas...

Major funding boost to bring world leading researchers to the John Innes Centre | John Innes Centre

The John Innes Centre has been awarded an equal share of the new £54 million Global Talent Fund, to attract and support leading researchers and their teams to relocate to the UK. The new Global Talent...

jic.ac.uk

Tung Le @tunglejic.bsky.social · last yr.

Fantastic opportunity to start your independent career at the JIC here. Great startup package. Repost = nice. Thank you!!!

Susan Schlimpert@s-lab.bsky.social · last yr.

New Independent Fellowship position in Microbiology to launch your lab in our department @johninnescentre.bsky.social (UK). We are conducting a broad search in the area of plant-associated microbial interactions. Message me if you have any questions. Apply here: www.jic.ac.uk/vacancies/in...

Journal of Experimental Botany @jxbotany.bsky.social · last yr.

🌾🧬 SPECIAL ISSUE RESEARCH 🌾🧬 📝 Varying gene dosage through mutating DNA methyltransferase 1-1 (MET1-1 ) in polyploid wheat generates quantitative changes to CG methylation without the lethal consequences observed in other crops - Burrows et al. 🔗 doi.org/10.1093/jxb/... #PlantScience 🧪

Fig. 1. (short legend see paper for full description): Null met1-1 mutants cannot be produced by crossing TILLING lines with disruptions in the three MET1-1 homoeologues. (A) Evolutionary relationships between MET1 homologues in Arabidopsis (AtMET1), rice (OsMET1a and OsMET1b), and wheat (homoeologue groups TaMET1-1, TaMET1-2, and TaMET1-3). (B) Crossing schematic showing the generation of the hexaploid MET1-1 populations: the C0465×C0884 population (top) and the C0451×C2028×C1292 population (bottom). (C) Structure of the three MET1-1 homoeologues. Filled rectangles represent exons, open rectangles represent untranslated regions, and lines represent introns. Triangles indicate the positions of the premature termination codon mutations in the TILLING lines used to produce the two hexaploid F2 populations (C0465×C0884, orange; C0451×C2028×C1292, purple). The green box signifies the Bromo adjacent homology domain (BAH) and the blue box signifies the C-5 cytosine methyltransferase domain.

Philippa Borrill @philippaborrill.bsky.social · last yr.

In #wheat mutants we've long wondered if the expression of homoeologs is upregulated to compensate. Could that explain homoeolog redundancy? Spoiler alert: no! Great summary by lead author @delfidorussen.bsky.social ⬇️ and the whole preprint is here: www.biorxiv.org/content/10.1... #plantscience

Homoeolog expression in polyploid wheat mutants shows limited transcriptional compensation

Active transcriptional compensation between gene duplicates (paralogs or homoeologs) has been proposed to facilitate functional redundancy, whereby mutations in multiple gene copies are required befor...

biorxiv.org

Delfi Dorussen@delfidorussen.bsky.social · last yr.

I'm excited to share our work investigating transcriptional compensation in polyploid wheat 🌾 It was fun to work on this project led by @philippaborrill.bsky.social and myself, with key contributions from @emilieknight.bsky.social and @simmojsimmo.bsky.social The key take-aways, a 🧵

Philippa Borrill @philippaborrill.bsky.social · last yr.

Wonderful to see such a range of plant model organisms featured in @cp-devcell.bsky.social. From crops like wheat and maize all the way through to liverworts, algae & ferns!🌾🌿🌽🥬🦠 Many opinions including why I propose using wheat as a model to investigate polyploidy: doi.org/10.1016/j.de...

Redirecting

doi.org

Philippa Borrill @philippaborrill.bsky.social · last yr.

It's an honour to be shortlisted for the Falling Walls Foundation Science Breakthrough of the Year 2025 for our work on epigenetics in crop breeding. I'm excited to see where this work leads us! Here we describe our first steps into epigenetic mutants in wheat doi.org/10.1093/jxb/...

John Innes Centre@johninnescentre.bsky.social · last yr.

Congratulations to Dr @philippaborrill.bsky.social and ‘Breaking the Wall of Epigenetics in Crop Breeding’ for being shortlisted for the Falling Walls Foundation Science Breakthrough of the Year 2025! 🌟 falling-walls.com/breakthroughs

John Innes Centre @johninnescentre.bsky.social · last yr.

EVENT - “Fundamental Biology of Legume Crops” Workshop Discuss the latest research in genomics, metabolomics, biotic interactions and plant development. 💻 Application deadline: 16 July 2025 🗓️ 3 - 4 November 2025 📍The John Innes Centre, NR4 7UH Find out more and apply: okt.to/fgZCWB

Philippa Borrill @philippaborrill.bsky.social · last yr.

Our latest work found that homoeolog expression bias is inherited for ~26% of triads in wheat. Intriguingly we found that new patterns of homoeolog expression bias are more frequent when one of the parents is a landrace. Read more in Genome Biology: rdcu.be/eokf2 @johninnescentre.bsky.social

Rapid reprogramming and stabilization of homoeolog expression bias in hexaploid wheat biparental populations

rdcu.be

Marek Glombik@glombikm.bsky.social · last yr.

Happy to share that our study of inheritance of homoeolog expression bias in wheat biparental populations is out in @biomedcentral.bsky.social Genome Biology! 🧬 Many thanks to all co-authors and @philippaborrill.bsky.social for great leadership on the project! #PlantScience #Botany rdcu.be/eokf2

Philippa Borrill @philippaborrill.bsky.social · last yr.

Looking for the direct target genes of a transcription factor in #wheat? Our protocol uses protoplasts, skipping transgenic plants to save months! Great step by step protocol @emilieknight.bsky.social! Read more below ⬇️ Thanks to all contributors! #plantscience @johninnescentre.bsky.social

Emilie Knight@emilieknight.bsky.social · last yr.

Pleased to have finally got this method to work in wheat! Find out how you can identify direct targets of transcription factors in wheat using protoplasts and the TARGET method: dx.doi.org/10.17504/pro... A very useful method for our group to use! borrilllab.com

Philippa Borrill @philippaborrill.bsky.social · last yr.

It was a pleasure to host @ismaelgf.bsky.social for 3 months @johninnescentre.bsky.social. Looking forward to continuing our collaboration with @irnasa.bsky.social on transcriptomic responses to water deficit in wheat 💦🍞🌾

IRNASA-CSIC@irnasa.bsky.social · last yr.

🌾 Our PhD student Ismael Gutiérrez has completed a research stay at the @johninnescentre.bsky.social exploring wheat responses to drought under climate change via omics data analysis. 📊 Thank you to Dr. @philippaborrill.bsky.social and her team for the warm welcome and training!

Nikolai Adamski @nikolaiadamski.bsky.social · last yr.

#Monogram2025 has finished. It was a fantastic conference with outstanding speakers and great interactions. I am very grateful to the organisers for their hard work!! (Especially Ash!) Looking forward to next year's conference hosted by NIAB. @monogram-uk.bsky.social @niab-uk.bsky.social

A picture showing the attendees of the Monogram2025 conference in Aberystwyth.

A picture of Dr Aiswarya Girija (Ash) receiving a thank you for her work coordinating the organisation if Monogram2025.

A picture showing the people who helped organise Monogram2025.

A picture revealing that Monogram2026 will be hosted by the NIAB institute in Cambridge.

Philippa Borrill @philippaborrill.bsky.social · last yr.

Congratulations to Isabel Faci @johninnescentre.bsky.social winner of the #Monogram2025 ECR excellence award! Fascinating talk on how decoupling environmental signals can induce aerial branching in wheat!

Philippa Borrill @philippaborrill.bsky.social · last yr.

Congratulations to @katielong.bsky.social @johninnescentre.bsky.social winner of the #Monogram2025 ECR excellence award! Fabulous talk on the intricate patterns of gene expression in wheat spikes!

Philippa Borrill @philippaborrill.bsky.social · last yr.

Wonderful talk from @delfidorussen.bsky.social at #Monogram2025 about DNA methylation mutants in wheat. You can read the full MET1-1 mutant characterisation which was just published this week @jxbotany.bsky.social ⬇️

Delfi Dorussen@delfidorussen.bsky.social · last yr.

I’m very happy to share the published version of our paper on the role of MET1 in wheat 🌾 🧬 It’s been really exciting to discover more about DNA methylation in wheat and it’s huge polyploid genome doi.org/10.1093/jxb/...

Philippa Borrill @philippaborrill.bsky.social · last yr.

Really enjoying #Monogram2025 so far @ibers.bsky.social Great talk by @chen-ji.bsky.social on her latest work exploring gene expression patterns in wheat grains. So many interesting genes to characterise!

Delfi Dorussen @delfidorussen.bsky.social · last yr.

Partial redundancy buffers deleterious effects of mutating DNA methyltransferase 1-1 (MET1-1) in polyploid wheat

Varying gene dosage through mutating DNA methyltransferase 1-1 (MET1-1 ) in polyploid wheat generates quantitative changes to CG methylation without the le

doi.org

Philippa Borrill @philippaborrill.bsky.social · last yr.

Looking forward to #Monogram2025 next week. Check out the programme below ⬇️ @monogram-uk.bsky.social

IBERS - Institute of Biological, Environmental and Rural Science@ibers.bsky.social · last yr.

We're looking forward to seeing everyone at the Monogram 2025 conference next week! 🌱🔬 Full eBooklet now available: www.aber.ac.uk/en/media/dep... See you there! #Monogram2025 #PlantScience #IBERS

Philippa Borrill @philippaborrill.bsky.social · last yr.

Starting to build our lab's interactions on bluesky. It appears we've got a positional effect from the summer lab photo 😂... @delfidorussen.bsky.social @chen-ji.bsky.social @beccatesta.bsky.social ... but not for alumnus @glombikm.bsky.social (top left of photo) @johninnescentre.bsky.social

Group photo of Borrill lab team with 4 bluesky account holders indicated by bluesky butterfly icon.

Philippa Borrill @philippaborrill.bsky.social · last yr.

Come hear Chen Ji talk about her fascinating results from spatial transcriptomics in wheat. There will be lots of beautiful images of gene expression patterns! 🗓️18-19 June in Norwich, UK Registration is open ⬇️

Earlham Institute@earlhaminst.bsky.social · last yr.

📣 We're excited to share our invited speakers for the 2025 Norwich #SingleCell and #Spatial symposium! Abstract submission is open for PhD and Early-Career researchers to present a short talk or poster during the symposium. buff.ly/3WPzXyJ

Invited speakers for Norwich Single-Cell and Spatial Symposium as follows: Chen Ji from the John Innes Centre. Melanie Krause from EMBL. Aimee Parker from the Quadram Institute. Kenny Roberts from the Wellcome Sanger Institute. And Tina Schreier from the University of Oxford.

Philippa Borrill @philippaborrill.bsky.social · 2y ago

Congratulations @delfidorussen.bsky.social on being awarded the #IWGSC -Feuillet Early Career award to present your work on #wheat homoeolog transcriptional compensation at PAG.🌾 #ProudPI.

International Wheat genome Sequencing Consortium@wheatgenome.bsky.social · 2y ago

Want to know more about #IWGSC-Feuillet Early Career Awardee Delfi Dorussen @johninnescentre.bsky.social ? Read her profile here: www.wheatgenome.org/people/early...