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Patrick Piantadosi

@ppiantad.bsky.social

behavioral neuroscientist @ NIAAA | climber & lover of sport | he / him | not @PiantadosiSean (but close)

4 Posts137 Follower 405 Folgt

Patrick Piantadosi @ppiantad.bsky.social · 4mo ago

Officially out today! Long-running project, many thanks to give - in particular to my mentors & collaborators, the postbacs who worked so hard on each experiment, and the reviewers. If you love the amygdala, give it a read. www.sciencedirect.com/science/arti...

Risk reshapes amygdala representation of choice

Modifying behavior in response to changing environmental conditions is a crucial adaptive function. This capacity is evident when animals curtail the …

sciencedirect.com

Patrick Piantadosi@ppiantad.bsky.social · 10mo ago

for anyone interested in the amygdala and risky decision-making, check out our new preprint: biorxiv.org/content/10.1... amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.

Vinny Costa @vincentcostaphd.bsky.social · 4mo ago

Instead of analyzing the IBL dataset, use your computational skills to analyze this dataset and your results will be 1,000 times more translationally relevant

Rudebeck Lab@rudebecklab.bsky.social · 4mo ago

Want a dataset to test ideas on neural basis of decision making or how areas interact as we make choices? Check out our data published today @rudebecklab.bsky.social. >16,000 single neurons from 22 anatomically confirmed areas in macaques performing a decision task. www.nature.com/articles/s41...

Tara Raam @tararaam.bsky.social · 5mo ago

Excited to share my postdoc work is out in @natneuro.nature.com today! We examined how the brain enables social groups to collectively coordinate their behavior in the face of environmental challenge ❄️🐭🐭🐭🐭❄️ : www.nature.com/articles/s41...

Cortical regulation of collective social dynamics during environmental challenge - Nature Neuroscience

Raam, Li, Gu and colleagues identify neural mechanisms underlying group huddling in mice during cold exposure. They find that the prefrontal cortex encodes decisions to huddle and that silencing neura...

nature.com

Vinny Costa @vincentcostaphd.bsky.social · 5mo ago

Monitoring gene expression in the brain with a simple blood test? In collaboration with @jerzyszablowski.bsky.social & his lab we figured out how to do it nonhuman primates using noninvasive neuroengineering of synthetic serum markers. nam11.safelinks.protection.outlook.com?url=https%3A...

ScienceDirect.com | Science, health and medical journals, full text articles and books.

nam11.safelinks.protection.outlook.com

Vinny Costa @vincentcostaphd.bsky.social · 6mo ago

This is a catastrophic unforced error. It was quite something to hear @ohsunews.bsky.social President Shereef Elnahal equate the shambolic lies of fringe groups (“others”) with the heartfelt & credible testimony of the scientists & veterinarians in his employ. “Teammates” don’t support rivals.

Science Magazine@science.org · 6mo ago

Breaking news: One of the largest monkey research centers in the United States has taken the first steps toward converting itself into a primate sanctuary, a seismic change that would affect biomedical research across the country. https://scim.ag/4bH2COV

Drew Schreiner @schreinerdrew.bsky.social · 7mo ago

Where does learning through imitation happen in the brain? In juvenile zebra finches, we pinpoint a synaptic locus of song learning in a cortico-basal ganglia circuit and leverage this localization to measure the timescale of consolidation and make birds learn faster! #neuroskyence (1/14)

A synaptic locus of song learning

Learning by imitation is the foundation for verbal and musical expression, but its underlying neural basis remains obscure. A juvenile male zebra finch imitates the multisyllabic song of an adult tutor in a process that depends on a song-specialized cortico-basal ganglia circuit, affording a powerful system to identify the synaptic substrates of imitative motor learning. Plasticity at a particular set of cortico-basal ganglia synapses is hypothesized to drive rapid learning-related changes in song before these changes are subsequently consolidated in downstream circuits. Nevertheless, this hypothesis is untested and the synaptic locus where learning initially occurs is unknown. By combining a computational framework to quantify song learning with synapse-specific optogenetic and chemogenetic manipulations within and directly downstream of the cortico-basal ganglia circuit, we identified the specific cortico-basal ganglia synapses that drive the acquisition and expression of rapid vocal changes during juvenile song learning and characterized the hours-long timescale over which these changes consolidate. Furthermore, transiently augmenting postsynaptic activity in the basal ganglia briefly accelerates learning rates and persistently alters song, demonstrating a direct link between basal ganglia activity and rapid learning. These results localize the specific cortico-basal ganglia synapses that enable a juvenile songbird to learn to sing and reveal the circuit logic and behavioral timescales of this imitative learning paradigm. ### Competing Interest Statement The authors have declared no competing interest. National Institutes of Health, K99 NS144525 (DCS), F32 MH132152 (DCS), F31 HD098772 (SB), R01 NS099288 (RM), RF1 NS118424 (RM and JP)

biorxiv.org

Debbie Yee @debyee.bsky.social · 10mo ago

Thrilled to share our new preprint highlighting distinct neurocomputational mechanisms underlying how reward and punishment determine adaptive cognitive control - a massive fMRI study and collaborative team effort with the @shenhavlab.bsky.social 🧠 Link here: www.biorxiv.org/content/10.1...

Neurocomputational mechanisms underlying the distinct motivational influences of reward and punishment on cognitive control

Human motivation is fundamentally shaped by one's expectations of the reward they could earn for good performance or the punishment they would avoid for poor performance. However, the extent to which ...

biorxiv.org

Patrick Piantadosi @ppiantad.bsky.social · 10mo ago

Risk reshapes amygdala representation of choice

Modifying behavior in response to changing environmental conditions is a crucial adaptive function. This capacity is exemplified when animals curtail pursuit of a valued outcome that risks being punis...

biorxiv.org

Beck Todd @beckety.bsky.social · 11mo ago

1. Media coverage of a new paper by @ryantomm.bsky.social w @brandonforys.com, @dr-stan.bsky.social et al. Building on Stan’s rodent work, Ryan found that > depression levels were associated w reduced capacity to learn to actively button-press to avoid a nasty sound www.medscape.com/viewarticle/...

Depression Curbs Ability to Actively Avoid Unpleasant Events

Depression in young patients is linked to difficulty in taking action to avoid something unpleasant, while the ability to withdraw and not act remains intact.

medscape.com

Mark Baxter 🏳️‍🌈🧂@markgbaxter.bsky.social · last yr.

This is absolutely revolutionary.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · last yr.

Synthetic Serum Markers Enable Noninvasive Monitoring of Gene Expression in Primate Brains https://www.biorxiv.org/content/10.1101/2025.06.01.657212v1

Drug Monkey @drugmonkey.bsky.social · last yr.

Please comment. The Administration is trying to turn the NIH IC Directors and program staff roles into political appointees that serve at the whim of the President. Imagine if each change in administration brought sweeping changes in professional NIH staff across your favorite ICs.

@KayTrue (Sarah L. Keller)@kaytrue.bsky.social · last yr.

Here are details about OPM-2025-0004. This would replace NIH Directors (non-partisan civil servants) with political appointees. Jeremy Berg has quick text to use: bsky.app/profile/jere.... A direct link for your comments is at: www.federalregister.gov/documents/20.... Cite Docket ID OPM-2025-0004

Kyle Griffin @kylegriffin1.bsky.social · last yr.

Maryland Sen. Chris Van Hollen is demanding a meeting with El Salvador President Nayib Bukele over the detention of Kilmar Abrego Garcia and says he’ll go to El Salvador himself if the Marylander isn’t returned.

The Transmitter @thetransmitter.bsky.social · last yr.

At least four neuroscientists received termination letters this week dismissing them from NIH advisory boards. “This is unusual and unprecedented,” says @thebalelab.bsky.social, one of the terminated board members. By @callimcflurry.bsky.social @avaskham.bsky.social #neuroskyence bit.ly/4hM0Xa3

Acting NIH director dismisses four neuroscientists from advisory boards

The letters they received this week did not include a reason for their termination.

thetransmitter.org

Katie Sandlin @kmsandlin.bsky.social · last yr.

I maxed out my credit card, emptied my savings account, and took out a loan to move from Alabama to Bethesda, MD. I don’t even qualify for unemployment since I’ve only worked at NIH for a month. I will be financially and medically devastated. Seeking suggestions for anywhere that’s hiring!!

Katie Sandlin@kmsandlin.bsky.social · last yr.

Today, along with 2,000 other NIH employees, I had to clear out my office 😭 It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.

Office desk without any personal items or decor

Sean Casten @seancasten.bsky.social · last yr.

To all those saying "shouldn't we root out government inefficiency? What's wrong with DOGE?" a quick background on Constitutional law and why the WAY it is being violated exposes the true motives of the criminals:

Miriam Goldstein @miriamgoldstein.bsky.social · last yr.

Just in case you thought that removing DEI criteria would mean that everyone is competing equally: NIH is removing grad students from underrepresented backgrounds from the applicant pool altogether. Their applications will not be considered. Other students, not from these backgrounds, will be.

Update: They were removed from our reviewer assignments completely. I'm so sorry to all those graduate students.

Anonymous to protect the identity of the NIH employee I spoke to...I am on study section next month to discuss F awards. We were just instructed to put the F31-Diversity applications on the bottom of our priority list for review because there is a chance we may not be able to review them. My heart is breaking for the grad students and their mentors that put so much work into these just for them to be disqualified and thrown out.

Phil Lewis @phillewis.bsky.social · 2y ago

Colombian President Gustavo Petro's full post ordering an increase of import tariffs on U.S. goods, says he doesn't really like traveling to the U.S. because it's “a bit boring” and invokes the ancestors

Trump, I don't really like travelling to the US, it's a bit boring, but I confess that there are some commendable things. I like going to the black neighbourhoods of Washington, where I saw an entire fight in the US capital between blacks and Latinos with barricades, which seemed like nonsense to me, because they should join together.

I confess that I like Walt Whitman and Paul Simon and Noam Chomsky and Miller

I confess that Sacco and Vanzetti, who have my blood, are memorable in the history of the USA and I follow them. They were murdered by labor leaders with the electric chair, the fascists who are within the USA as well as within my country

I don't like your oil, Trump, you're going to wipe out the human species because of greed. Maybe one day, over a glass of whiskey, which I accept, despite my gastritis, we can talk frankly about this, but it's difficult because you consider me an inferior race and I'm not, nor is any Colombian.

So if you know someone who is stubborn, that's me, period. You can try to carry out a coup with your economic strength and your arrogance, like they did with Allende. But I will die in my law, I resisted torture and I resist you. I don't want slavers next to Colombia, we already had many and we freed ourselves. What I want next to Colombia are lovers of freedom. If you can't accompany me, I'll go elsewhere. Colombia is the heart of the world and you didn't understand that, this is the land of the yellow butterflies, of the beauty of Remedios, but also of the colonels Aureliano Buendía, of which I am one, perhaps the last.

You will kill me, but I will survive in my people, which is before yours, in the Americas. We are peoples of the winds, the mountains, the Caribbean Sea and of freedom.

You don't like our freedom, okay. I don't shake hands with white slavers. I shake hands with the white libertarian heirs of Lincoln and the black and white farm boys of the USA, at whose graves I cried and prayed on a battlefield, which I reached after walking the mountains of Italian Tuscany and after being saved from Covid.

They are the United States and before them I kneel, before no one else.

Overthrow me, President, and the Americas and humanity will respond.

Colombia now stops looking north, looks at the world, our blood comes from the blood of the Caliphate of Cordoba, the civilization of that time, of the Roman Latins of the Mediterranean, the civilization of that time, who founded the republic, democracy in Athens; our blood has the black resistance fighters turned into slaves by you. In Colombia is the first free territory of America, before Washington, of all America, there I take refuge in its African songs.

My land is made up of goldsmiths who worked in the time of the Egyptian pharaohs and of the first artists in the world in Chiribiquete.

You will never rule us. The warrior who rode our lands, shouting freedom, who is called Bolívar, opposes us.

Our people are somewhat fearful, somewhat timid, they are naive and kind, loving, but they will know how to win the Panama Canal, which you took from us with violence. Two hundred heroes from all of Latin America lie in Bocas del Toro, today's Panama, formerly Colombia, which you murdered.

I raise a flag and as Gaitán said, even if it remains alone, it will continue to be raised with the Latin American dignity that is the dignity of America, which your great-grandfather did not know, and mine did, Mr. President, an immigrant in the USA,

Your blockade does not scare me, because Colombia, besides being the country of beauty, is the heart of the world. I know that you love beauty as I do, do not disrespect it and you will give it your sweetness.

FROM TODAY ON, COLOMBIA IS OPEN TO THE ENTIRE WORLD, WITH OPEN ARMS, WE ARE BUILDERS OF FREEDOM, LIFE AND HUMANITY.

I am informed that you impose a 50% tariff on the fruits of our human labor to enter the United States, and I do the same.

Let our people plant corn that was discovered in Colombia and feed the world

Phil Lewis@phillewis.bsky.social · 2y ago

BOGOTÁ, Colombia (AP) — Colombian president orders increase of import tariffs on US goods in retaliation to similar order from President Trump.

Daniel Cardozo Pinto @dcardozopinto.bsky.social · 2y ago

My paper is out!! 🎉 "Opponent control of reinforcement by striatal dopamine and serotonin", @Nature Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain THREAD ⬇️ 1/n