Chris Nickson

@precordialthump.bsky.social

Intensivist, ECMO specialist, Clinician Educator. Calm amid a #FOAMed storm: LITFL.com & INTENSIVEblog.com

Pity they massively overdosed the ketamine arm - significant percentage > 2mg/kg / no ceiling dose ("rule of 1 ampoule") / dose per total body weight / and who gives > 0.5 mg/kg to a "sick" patient - great trial / wrong pharmacology / wrong conclusion = drugs are equivalent at equipotent doses

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The Worlds Best Intensive Care Meeting is up and running - Critical Care Reviews Down Under - triallist, editorialist, statistician, expert panel - an hour - not 10 mins - and that is the outside behind them - Naarm (Melbourne)

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Editorial by JAMA Senior Editor Derek Angus: The ImmunoSep RCT demonstrates the feasibility of biomarker-guided treatment, while highlighting ongoing challenges in immune classification and broader clinical application. #CCRdownunder ja.ma/3Kg3qz3

JAMA article "Precision Therapy for Sepsis The End of the Beginning?" by Derek C. Angus, MD, MPH. Article discusses sepsis treatment, host response, and clinical trials.