Prof John Gordon
@profcelentyx.bsky.social
B Cell Enthusiast; Immunology Prof (Emeritus, but Still Breathing); Big on Immunotherapy; Love Herefordshire; & Curries 😃 Any views and comments are strictly personal
Thrilled and honoured to be invited onto the Scientific Advisory Panel of the Centre for Human-Specific Research 😊 humanspecificresearch.org
Incredible #infection #immunity #cancer #Bcells #Tcells Resource 👏 Top of the Human League 🙋♂️🙋♀️
bioRxiv Immunology@biorxiv-immuno.bsky.social · 10mo agoHuBIE: The Human Blood Immunome Encyclopedia Of TCRs and BCRs in Bloodstream Infections and Cancer https://www.biorxiv.org/content/10.1101/2025.10.22.678684v1
#cancersky #immunosky #antibodysky Major #CD40 #TherapeuticAntibody Success now breaking @cp-cancercell.bsky.social First-in-Human study of Fc-optimised CD40 agonistic Antibody elicits #TertiaryLymphoidStructures & systemic anti-Tumor #Immunity in Metastatic #Cancer Fantastic work 👏
Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer
Osorio et al. report a first-in-human study of intratumoral 2141-V11, an Fc-engineered CD40 agonistic antibody, showing it is safe and induces systemic and durable antitumor immunity in patients with ...
cell.com
Dr Neil Bodie (June 13, 1955 - July 19, 2025) It is with a heavy heart that I report the sad news that my "LinkedIn Friend" & Colleague Dr Neil Martin Bodie, passed away on July 19th. For more about Neil please see: www.linkedin.com/feed/update/... R.I.P. Dear Friend Thoughts are with his family
Major study, great work 👍
Chrystal Paulos@chrystalpaulos.bsky.social · last yr.🧵1/ New in @Cancer_Cell: Our lab discovered that Th17 cells must team up with B cells to eliminate tumors, and prevent it from coming back. 🔗 Read: www.cell.com/cancer-cell/... 🧬This unexpected immune duo sparks tumor immunity. 🖼️Image: See schematic Th17/B cell antitumor action!
#immunosky #cancersky #climatechangesky #PsychoNeuroImmunology #ClimateChange / #SocialDivision: A Perfect Storm for Chronic #Inflammation to Seedbed #Cancer? Intriguing, OPEN ACCESS Opinion Piece now breaking at @wiley.com #Immunology
Inflammation Perfect Storm: Cancer, Climate and Polarisation
Interplay between major global challenges and human health. Climate change and sociopolitical polarisation act as overarching amplifiers, driving specific environmental and psychosocial/policy-relate...
onlinelibrary.wiley.com
A Perfect Selection 😉
Gabriel Victora@victora.bsky.social · last yr.Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch www.biorxiv.org/content/10.1...
Fantastic advance 👏
Thiago Carvalho@cyrilpedia.bsky.social · last yr.'Here, we report that Fc-optimized anti-CTLA-4 antibodies are potent remodelers of tumor vasculature that increase tumor-associated high endothelial venules (TA-HEVs), specialized blood vessels supporting lymphocyte entry into tumors' #Immunology #Immunotherapy www.cell.com/cell-reports...
Clucking Awesome 🐓
Discovery Immunology@discovimmunol.bsky.social · last yr.How do chickens generate antibody diversity? 🐔🔬 This study maps over 1 million gene conversion events in chicken antibodies, shedding light on how birds diversify their immune response. 🔗 https://bit.ly/45wSe95 #Immunology #VetImmunology #GeneConversion
A fantastic #MS resource from @britsocimm.bsky.social 👍
British Society for Immunology@britsocimm.bsky.social · last yr.🧡 Today is #WorldMSDay - a global moment to raise awareness and stand with everyone affected by multiple sclerosis. Curious about how the immune system plays a role in MS? Explore our easy-to-digest BiteSized Immunology section on MS. 📖Learn more here: https://bit.ly/4dFYj5i
#Immunosky #Cancersky Antidepressants: A “Dead SERT” for #Immunotherapy! Open Access @cellpress.bsky.social @gilliangrafton.bsky.social 😎
Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis
Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell ...
cell.com
#CancerSky #MedSky "When #Cancer #Therapy faces STIFF competition" OPEN ACCESS Review @cp-trendscancer.bsky.social
Tissue mechanics in tumor heterogeneity and aggression
Tumorigenesis ensues within a heterogeneous tissue microenvironment that promotes malignant transformation, metastasis and treatment resistance. A major feature of the tumor microenvironment is the he...
cell.com
#ImmunoSky #MedSky #CancerSky "Strengthening the #GLUT5" for #ACT vs Solid #Tumours" Breaking OPEN ACCESS Study @britsocimm.bsky.social journal @imtadvances.bsky.social 👏
GLUT5 armouring enhances adoptive T cell therapy anti-tumour activity under glucose-limiting conditions
AbstractBackground. Cancer immunotherapy with engineered T cells has become a standard treatment for certain haematological cancers. However, clinical tria
academic.oup.com
#ImmunoSky #InflammationSky #DietSky #ILC3s #Immunity #Inflammation #Mucosa #Metabolism #Nutrition #Diet #IL22 "Trust Your #Gut" & Stay Off those Big Macs 🍔 @wehi-research.bsky.social researchers Cyril Seillet & Friends "Chew the #Fat" in Breaking OPEN ACCESS Study @cp-immunity.bsky.social
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...
cell.com
#ImmunoSky #MedSky #CancerSky #PharmaSky #DrugSky **BREAKING: Massive layoffs hit the rodent workforce!** In a historic shift, the FDA is exploring a future without animal studies for drug approvals. BRILLIANT Joseph Arboleda Velasquez @harvard.edu 🤩👍👏 www.linkedin.com/posts/joseph...
#CancerSky #ImmunoSky #MedSky #Cancer #Aging #Metabolism #TIME to Watch you Eat' #Age- & #Diet- instructed Metabolic Rewiring of the #TumorImmuneMicroEnvironment #TIME-ly review from @unil.bsky.social authors now breaking at @jem.org rupress.org/jem/article/...
#ImmunoSky #MedSky #drugrepurposing #Inflammation: "Time to halt the #Dopamine rush" An anti- #Psychotic Drug stimulates #Macrophages to clear #Pathogenic Cells by inducing #Arginase-1 & continual #Efferocytosis Now @science.org signaling
The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis
Macrophages perform repeated rounds of phagocytosis in response to an FDA-approved dopamine blocker.
science.org
#ImmunoSky #MedSky #EarlyCareerResearchers #Careers @ki.se
From Serendipity to Success - Researcher blogs % | John Gordon
#Serendipity | Delighted to share this lovely post from the hugely talented Austeja Baleviciute of the Karolinska Institutet 😊 Hopefully will offer some useful tips to early career researchers as they...
linkedin.com
#ImmunoSky #Immunotherapy #ImmuneRelatedAdverseEvents #Biomarkers #ICOS+ CD4 #Tcells define #Susceptibility to anti-PD1-induced #Lung #Pathology in the #Aged #Bcells #Antibodies #TertiaryLymphoidStructures Breaking Open Access Study @jci-insight.bsky.social insight.jci.org/articles/vie...
Maximizing activity & selectivity of #TherapeuticAntibodies mediated effector functions using Antibody mixtures Breaking Open Access Study* @tandfresearch.bsky.social #mAbs *https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2480666?src=exp-la#abstract
#Bcells & #VaccinesSaveLives Towards a pan- #Flu #Vaccine Identification of a seasonal influenza vaccine–induced broadly protective neuraminidase antibody Breaking Open Access Study* @jem.org *https://rupress.org/jem/article/222/6/e20241930/277361/Identification-of-a-seasonal-influenza-vaccine
#flu #vaccine #protective #antibody #jem #bcells #vaccinessavelives | John Gordon
Towards a pan-#Flu #Vaccine | Identification of a Seasonal Influenza Vaccine-induced Broadly #Protective Neuraminidase #Antibody | Breaking Open Access Study at Rockefeller University Press #JEM | #Bc...
linkedin.com
Targeting the #FcRn in #AutoimmuneDiseases: Pipeline & Progress Torleif Tollefsrud Gjølberg & Colleagues Dig Deep into the Biology of the Neonatal Fc Receptor & its Antagonism in Superlative Breaking Open Access Review
Targeting the Neonatal Fc Receptor in Autoimmune Diseases: Pipeline and Progress - BioDrugs
Autoimmune diseases are highly prevalent and affect people at all ages, women more often than men. The most prominent immunological manifestation is the production of antibodies directed against self-...
link.springer.com
#MyeloidCell path to #Malignancy: insights into #Liver #Cancer SUPERLATIVE OPEN ACCESS REVIEW from Christel Ramirez & @leilaakkari.bsky.social at @cp-trendscancer.bsky.social 👏 www.cell.com/action/showP...
Time to Zap moDc to reverse #Radiotherapy resistance ☢️ Breaking Open Access Study @jem.org 👍
CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy | Journal of Experimental Medicine | Rockefeller University Press
Radiotherapy not only kills tumors but also shapes immunity. This study reveals that in radioresistant tumors, clinically relevant radiotherapy induces GM-
rupress.org
Breaking Study @nature.com #VaccineDesign with a #STING in its tail 🦂 Perfect for @britsocimm.bsky.social #Vaccine Awareness Day 👍
Crucial meeting: molecule helps vaccine to interact with killer T cells
Vaccines containing peptides called antigens are bad at stimulating key immune cells called killer T cells. A molecule now enables antigens to encounter these T cells.
nature.com
👏 #Antibodies 👏 #Immunity 👏 #Influenza 👏 #Vaccines 👏 Thank Goodness for #Bcells 😊 On @britsocimm.bsky.social #Vaccine Engagment Day check out this exciting new study from @guthmillerjenna.bsky.social et al at @cp-immunity.bsky.social: www.cell.com/immunity/abs...
#bcells #immunity #vaccinedesign | John Gordon
#Bcells | "STALK-ing 'Flu" at #Immunity Cell Press: "Playing the Long Game" | Major #VaccineDesign Study by Jenna Guthmiller et al Now Breaking Online | In…
linkedin.com
#Bcells #Antibodies #Vaccines #STALKing #Flu: "Playing the Long Game" Major #VaccineDesign Study by @guthmillerjenna.bsky.social & Friends now breaking at @cellpress.bsky.social #Immunity
Long-lasting B cell convergence to distinct broadly reactive epitopes following vaccination with chimeric influenza virus hemagglutinins
Next-generation influenza vaccines aim to overcome the limitations of current seasonal vaccines and generate durable and broadly protective immunity against influenza by targeting conserved epitopes. ...
cell.com