Ivan Ferreira

@ptychodera.bsky.social

Biologist from 🇧🇷 jointly based at Stowers and the Hopkins Marine Station at Stanford | PhD from Oxford | genomics, embryos, worms, regeneration | USP and Butantan alumnus | my opinions

Incredible! Scientists receive a rare standing ovation after announcing that a new treatment can double the survival time for pancreatic cancer, the deadliest cancer which was once considered “undruggable.” When we fund and support science, we can achieve anything! (Video: Dr. Wish Dhillon)

For all undergrad/grad students and postdocs going to the #embo #regeneration meeting in Austria this year: highly recommend joining the trainee pre-meeting co-organized by Giulia, Carlos and Salome in beautiful Vienna! Honestly - just the chance to visit the Vienna BioCenter is worth it

Giulia Casal, PhD@giuliacasal.bsky.social · 2mo ago

We are organising a trainee pre-meeting ahead of the EMBO Workshop @embo.org @isrbio.bsky.social If you’re an undergrad/MSc/PhD or postdoc interested in regenerative biology, join us in Vienna for trainee talks, networking, and discussions with keynote speakers about their scientific journey.

This is awful to hear, describing how Sean Eddy (HMMER, infernal, pfam, rfam) has been defunded. The letter said his work "had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated," www.npr.org/2026/05/21/n...

Researchers say the Trump administration is finding new ways to punish science

Even with federal grants largely restored, scientists say the Trump administration is still preventing those funds from reaching them. The consequences, they say, are already becoming clear.

npr.org

This definitely forbidden gummy is in fact a moth larva of genus Olona (possibly Olona zolotuhini). It's *normal* to want to know what flavor it is, but the answer, unfortunately is "pain". Most species in this family are covered in tiny stinging spines connected to poison glands. (📷: Janice Ang)

"Science is not simply a sequence of tasks that can be optimized....The scientific system thrives on inefficiency: redundant efforts, failed attempts, and divergent paths. These are not costs to be eliminated but sources of discovery." Excellent essay! ⬇️ www.science.org/doi/10.1126/...

Progression without progress

Progress in the use of artificial intelligence (AI) to advance scientific discovery has made it increasingly realistic to envision automated “end-to-end science” (ETES) systems: integrated pipelines t...

science.org

“…a past strong El Niño event wiped out 77 percent of the islands' penguins. In addition, the climate pattern destroyed 97 percent of shallow water coral.” If this El Niño turns out as predicted, it will have devastating effects on biodiversity across the globe. www.newsweek.com/super-el-nin...

Most Galapagos penguins could be killed this year, here's why

More than three-quarters of the penguins' population died during a separate strong El Niño event, fueling concerns for this year.

newsweek.com

One of my dream projects, ever since joining here in Basel, out now in @nature.com : single-cells 🤝 eco-morphological proxies rdcu.be/fiyso How cells and tissues adapt to dietary niches... Thanks and congrats to Antoine, Walter, and all the other co-authors for this great collaboration!! 🙏🥳

Adaptive cellular evolution in the intestine of hyperdiverse cichlid fishes

Nature - Single-cell transcriptomics combined with morphological and ecological data show that the rapid evolutionary radiation of cichlid fishes in Lake Tanganyika was accompanied by dietary...

rdcu.be

While BioNtech & Moderna become household names because of their Covid vaccines, those emerged from different projects: finding ways to treat the most challenging cancers. They hypothesized that we could vaccinate patients against their own tumors, & evidence is mounting that they were right! 1/n 🧪

https://www.nature.com/articles/s41586-025-10004-2
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC

    U. Sahin, M. Schmidt, E. Derhovanessian, A. Cortini, I. Vogler, T. Omokoko, E. Godehardt, S. Attig, S. Newrzela, J. Grützner, N. Bidmon, S. Bolte, S. Brachtendorf, T. Stuhlmann, D. Langer, D. Brüne, J. Blake, A. Feldner, H. Lindman, A. Schneeweiss, M. Eichbaum & Ö. Türeci 
Triple-negative breast cancer (TNBC) is frequently associated with metastatic relapse, even at an early stage1. Here we assessed an individualized neoantigen mRNA vaccine in 14 patients with TNBC following surgery and after neoadjuvant or adjuvant therapy. In peripheral blood of nearly all patients, high-magnitude, vaccine-induced, mostly de novo T cell responses to multiple neoantigens were detected that remained functional for several years. Characterization of individual patients revealed that a large proportion of these T cells developed into two subsets: a late-differentiated phenotype with markers indicative of ‘ready-to-act’ cytotoxic effector T cells, and T cells with a stem cell-like memory phenotype. Eleven patients remained relapse-free for up to six years post-vaccination. Recurrence occurred in three patients: the individual with the weakest vaccine-induced T cell response relapsed, but achieved complete remission on subsequent anti-PD-1 therapy; another patient had a tumour with low major histocompatibility complex (MHC) class I expression with MHC class I-deficient cells growing out under vaccination; and the third patient was BRCA-positive and had a recurrence from a genetically distinct primary tumour. These findings demonstrate the feasibility of individualized RNA vaccines in TNBC, document persistence of vaccine-induced, functional neoantigen-specific T cells and provide insights into possible immune escape mechanisms that will guide future approaches.

Truly historic & moving scenes from the inaugural session of the Hungarian Parliament. A children’s tambura band from a tiny village playing a folk song often described as the unofficial Roma anthem. MPs were tearing up & so were many more of us watching. After all those years of hate. 🎥 telex.hu

In retrospect, forcing the entire campus to move from our locally hosted, open source LMS to a commercial, single point of failure LMS that also happens to be owned by a company that wants to turn all our labor into AI training data may not have been a good idea.